Results 61 to 70 of about 37,464 (275)

Long-isoform NFE2L1 silencing inhibits acquisition of malignant phenotypes induced by arsenite in human bronchial epithelial cells

Ecotoxicology and Environmental Safety, 2022
Chronic arsenic exposure is associated with the increased risk of several types of cancer, among which, lung cancer is the most deadly one. Nuclear factor erythroid 2 like 1 (NFE2L1), a transcription factor belonging to CNC-bZIP family, regulates ...
Yongfang Li, Ru Sun, Xin Fang, Yihui Ruan, Yuxin Hu, Kemu Wang, Jiao Liu, Huihui Wang, Jingbo Pi, Yanyan Chen, Yuanyuan Xu   +10 more
doaj   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Arsenite exposure suppresses adipogenesis, mitochondrial biogenesis and thermogenesis via autophagy inhibition in brown adipose tissue

Scientific Reports, 2019
Arsenite, a trivalent form of arsenic, is an element that occurs naturally in the environment. Humans are exposed to high dose of arsenite through consuming arsenite-contaminated drinking water and food, and the arsenite can accumulate in the human ...
Jiyoung Bae, Yura Jang, Heejeong Kim, Kalika Mahato, C. Schaecher, Isaac M. Kim, Eunju Kim, Seung-Hyun Ro   +7 more
semanticscholar   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

Synergistic Ameliorative Capabilities of Quercetin and Ascorbic Acid on Hepatic and Pro-Inflammatory Markers of Arsenic-Induced Toxicity in Obese Wistar Rats

Fountain Journal of Natural and Applied Sciences (FUJNAS)
Obesity and arsenic exposure have been linked to many health issues. However, arsenic poisoning severity and susceptibility may depend on Body Mass Index (BMI), oxidative state, food supplements, and other factors.
Adeola Busayo Adenmosun, Omowumi Oyeronke Adewale, Tope G. Atere, Olu Israel Oyewole   +3 more
doaj   +1 more source

A Comparison among Synthetic Layered Double Hydroxides (LDHs) as Effective Adsorbents of Inorganic Arsenic from Contaminated Soil–Water Systems

Soil Systems, 2020
The need for cost-effective adsorbents of inorganic arsenic (As(III) and As(V)) stimulates the academia to synthesize and test novel materials that can be profitably applied at large-scale in most affected areas worldwide.
Massimo Pigna, Antonio Violante, Antonio Giandonato Caporale   +2 more
doaj   +1 more source

N6-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells.

Toxicology Letters, 2018
N6-methyladenosine (m6A) modification is implicated to play an important role in cellular biological processes, but its regulatory mechanisms in arsenite-induced carcinogenesis are largely unknown.
Shiyan Gu, Donglei Sun, Huangmei Dai, Zunzhen Zhang   +3 more
semanticscholar   +1 more source

Exploring Interactive Effects of Arsenic and Selenium Exposure on Larval Zebrafish (Danio rerio)

Environmental Toxicology, EarlyView.
ABSTRACT Arsenic contamination in aquatic ecosystems is a major environmental concern. Selenium (Se) helps mitigate oxidative stress and hence could reduce the toxic effects of arsenic. However, Se can also be toxic at high concentrations. Given that these metalloids commonly co‐occur in the environment, there is a pressing need for further research ...
Owen Luo, Jinnath Rehana Ritu, Md Helal Uddin, Sravan Kumar Putnala, Mahesh Rachamalla, Som Niyogi, Douglas P. Chivers   +6 more
wiley   +1 more source

Arsenite accumulation in the mouse eye [PDF]

Journal of Toxicology and Environmental Health, Part A, 2016
Elevated arsenic (As) concentrations in drinking water are a major worldwide public health concern. Exposure to As is associated with carcinogenesis, skin lesions, cardiovascular disease, cognitive deficits, and other disorders. However, little is known regarding chronic As-mediated effects on the eye.
Norman J, Kleiman, Adrienne M, Quinn, Kara G, Fields, Vesna, Slavkovich, Joseph H, Graziano   +4 more
openaire   +2 more sources

Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure

Neurotoxicology, 2018
Ferroptosis is a novel iron‐dependent form of cell death implicated in brain pathology. However, whether arsenite is an inducer of ferroptosis in the neuron remains completely unknown.
Qianghu Tang, Lulu Bai, Zhen Zou, P. Meng, yinyin xia, Shuqun Cheng, Shaoyu Mu, Jianrong Zhou, Xue-feng Wang, Xia Qin, Xianqing Cao, Xuejun Jiang, Chengzhi Chen   +12 more
semanticscholar   +1 more source