Results 21 to 30 of about 251,938 (219)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Alchemilla vulgaris cytoprotection against methyl methanesulfonate by experimental and molecular docking approaches

Scientific Reports
Methyl methanesulfonate (MMS) is a chemical compound that exerts an alkylating effect on DNA and proteins. Alchemilla vulgaris L. is a medicinal plant known for its rich bioactive composition and pharmacological potential.
Tuğçe Kalefetoğlu Macar, Oksal Macar, Emine Yalçın, Kültiğin Çavuşoğlu, Ali Acar   +4 more
doaj   +1 more source

Flood Hazard Detection in Data-Scarce Regions: A Case Study of a Semi-Arid River in Northeastern Morocco [PDF]

BIO Web of Conferences
Forecasting flood hazard areas often presents substantial challenges in data-scarce regions. In our case study, we used HEC-RAS model to identify flood risk zones for various return periods along an ungauged river in a semi-arid region.
Layan Badr, Benaabidate Lahcen, Zemzami Mahmoud, Hanchane Mohamed, Ben Abbou Mohamed   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The role of Lavandula stoechas L. extract in enhancing tolerance to prometryn toxicity

Scientific Reports
The aim of this study was to determine the tolerance-enhancing effect of Lavandula stoechas L. (LSE) against prometryn herbicide using Allium cepa.
Oksal Macar, Tuğçe Kalefetoğlu Macar, Kültiğin Çavuşoğlu, Emine Yalçın, Ali Acar   +4 more
doaj   +1 more source

Technical methods for forming post-modern arts and their manifestations in the products of students of Art Education (pop art as an example)

الاكاديمي
The research dealt with the topic of technical methods for forming post-modern arts and their manifestations in the products of art education students, which occur in displaying and directing their artistic achievement.
Sahera Fakhri Salama
doaj   +1 more source

Impact of atmospheric particulate matter retention on physiological characters of five plant species under different pollution levels in Zhengzhou [PDF]

PeerJ
Atmospheric particulate matter (PM) pollution has become a major environmental risk, and green plants can mitigate air pollution by regulating their enzymatic activity, osmoregulatory substances, photosynthetic pigments, and other biochemical ...
Dan He, Jiangqin Yuan, Runze Lin, Dongbo Xie, Yifei Wang, Gunwoo Kim, Yakai Lei, Yonghua Li   +7 more
doaj   +2 more sources

Methodological aspects of the implementation of Printmaking in Pre-school, Primary and Secondary education

Arte, Individuo y Sociedad, 2020
Printmaking, with its technical complexity, has often been neglected in educational praxis, even though it is a discipline which contributes significantly in the developing of children`s creativity.
Milica Vojvodić, Jelena Sredanović
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source