Results 141 to 150 of about 74,638 (327)

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

Changes in Malaria Patterns in Comoros from 2010 to 2021: A Comparative Study with Sub-Saharan Africa

Tropical Medicine and Infectious Disease
Background: Recent setbacks in malaria control in Comoros demand a reassessment of its evolving epidemiology. Methods: Using the Global Burden of Disease (GBD) Study 2021 data, we analyzed malaria trends from 2010 to 2021, stratified by sex.
Sheng Zhou, Linxin Yu, Jianming Liang, Wei Xie, Guoming Li, Changsheng Deng, Jianping Song, Guanyang Zou, Yinhuan Chen   +8 more
doaj   +1 more source

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model [PDF]

, 2016
Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies.
Baro, Nicholas, Buckee, Caroline, Childs, Lauren M., Daniels, Rachel, Dow, Geoffrey S., Duraisingh, Manoj T., Gerena, Lucia, Kyle, Dennis, Mantel, Pierre-Yves, Marti, Matthias, Mukherjee, Angana, Obaldía III, Nicanor, Otero, William, Volkman, Sarah K., Wirth, Dyann F.   +14 more
core   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, EarlyView.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Plant Cellular and Molecular Biotechnology: Following Mariotti's Steps [PDF]

, 2019
This review is dedicated to the memory of Prof. Domenico Mariotti, who significantly contributed to establishing the Italian research community in Agricultural Genetics and carried out the first experiments of Agrobacterium-mediated plant genetic ...
Caretto, Sofia, Frugis, Giovanna, Giannino, Donato, Iannelli, Maria Adelaide, Mauro, Maria Luisa, Mele, Giovanni, Nicolodi, Chiara, Paolis, Angelo De, Rugini, Eddo, Silvestri, Cristian, Sparvoli, Francesca, Testone, Giulio   +11 more
core   +1 more source

Amelioration of the rheumatoid arthritis microenvironment using celastrol-loaded silver-modified ceria nanoparticles for enhanced treatment

Journal of Nanobiotechnology
Rheumatoid arthritis (RA) is characterized by elevated levels of reactive oxygen species (ROS) and a persistent inflammatory microenvironment dominated by M1 macrophages, both of which contribute to disease progression.
Xiaoru Zhang, Xiaguo Fu, Wanying Chen, Peng Chen, He Zhu, Bo Yang, Jianming Liang, Feng Zeng   +7 more
doaj   +1 more source

Graphene oxide enhances aphid resistance in sorghum via the miR319‐SbTCP7‐SbLOX3 Pathway

Plant Biotechnology Journal, EarlyView.
Summary The aphid (Melanaphis sacchari) has emerged as a formidable pest, devastating sorghum plants and highlighting the need for sustainable management strategies. Graphene oxide (GO), as a novel material, has garnered attention for its use in crop cultivation and management, but its effects on biotic stresses remain elusive. Here, we used 10 mg/L GO
Yannan Shi, Zhiyin Jiao, Jinping Wang, Zhifang Wang, Cheng Chu, Yongchao Guo, Peng Lv, Junfeng Cao   +7 more
wiley   +1 more source

Exploring the Underlying Mechanisms of Qingxing Granules Treating H1N1 Influenza Based on Network Pharmacology and Experimental Validation

Pharmaceuticals
Background: H1N1 is one of the major subtypes of influenza A virus (IAV) that causes seasonal influenza, posing a serious threat to human health. A traditional Chinese medicine combination called Qingxing granules (QX) is utilized clinically to treat ...
Hujun Du, Lianying Zhang, Haoxiang Sun, Shaoqin Zheng, Hongying Zhang, Shijia Yuan, Jiuyao Zhou, Zihao Fang, Jianping Song, Manxue Mei, Changsheng Deng   +10 more
doaj   +1 more source

Preparation and Physicochemical Characterization of Biodegradable mPEG-PCL Core-Shell Micelles for Delivery of Artemisinin

Pharmaceutical Sciences, 2016
Background: Artemisinin is a sesquiterpene lactone chemical extract from Artemisia annua, is poorly resolvable in water and a fast-acting blood active in treating the acute attack of malaria. Methods: Artemisinin was encapsulated within mPEG-PCL micelles
Hamid Reza Kheiri Manjili 1, Hojjat Malvandi 3, Mir-Sajjad Mosavi 1, Hossein Danafar 2,3 *
doaj   +1 more source