Artemisinin resistance - Open Access .click

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Science, 2020
Malaria Species of the malaria parasite Plasmodium live in red blood cells and possess a highly conserved gene called kelch13 . Single point mutations in this gene are associated with resistance to the frontline artemisinin drugs. Birnbaum et al. found that Kelch13 and associated proteins comprise an endocytic compartment associated with feeding on ...
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Artemisinins: mechanisms of action and potential for resistance

Drug Resistance Updates, 2004
Artemisinins form the most important class of antimalarial currently available, particularly because they are effective against parasites resistant to almost all the other classes. Their mechanism of action is controversial. Some aspects of this controversy are reviewed here.
Krishna, S., Uhlemann, AC, Haynes, RK
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Understanding artemisinin resistance

Science, 2015
Genetic studies provide clues to how malaria parasites become drug resistant [Also see Reports by Straimer et al. and Mok et al. ]
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Deciphering the signatures of artemisinin resistance

Journal of Antimicrobial Chemotherapy, 2023
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Evidence of Artemisinin-Resistant Malaria in Africa