Results 101 to 110 of about 17,496 (173)

Artemisinins in autoimmune diseases: effects and mechanisms in systemic lupus erythematosus and rheumatoid arthritis

British Journal of Pharmacology, Volume 182, Issue 15, Page 3411-3427, August 2025.
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou, Guoming Li, Ruixiang Tan, Guodong Wu, Changsheng Deng   +4 more
wiley   +1 more source

Comparative study of the effects of artemether and artesunate on juvenile and adult Schistosoma mansoni in experimentally infected mice [PDF]

, 2017
Artemether and artesunate, derivatives of the antimalarial artemisinin, also exhibit antischistosomal properties. There is a need to assess comparatively the activity of both compounds against different developmental stages of schistosome parasites ...
Chollet, Jacques, Shuhua, Xiao, Tanner, Marcel, Tu, Zuwu, Utzinger, Jürg   +4 more
core  

Reprint of “Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin” [PDF]

, 2014
A four compartment mechanistic mathematical model is developed for the pharmacokinetics of the commonly used anti-malarial drug artesunate and its principle metabolite dihydroartemisinin following oral administration of artesunate.
Aston, John A.D., Chappell, Michael J., Hall, Adam J., Ward, Stephen   +3 more
core   +1 more source

Appraising the visibility, relevance and impacts of clinical pharmacology

British Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 1884-1898, July 2025.
Aims Clinical pharmacology (CP) used to be a strong medical and scientific field, but during the last three decades it seems to have lost some of its appeal. We reviewed the visibility, relevance and impact of CP and clinical pharmacologists across the globe and suggest ways to strengthen the discipline to address future pharmacotherapeutic challenges.
Serge Cremers, Samuel L. M. Arnold, Nilima A. Kshirsagar, Catriona Waitt, Olayinka O. Ogunleye, Lars L. Gustafsson   +5 more
wiley   +1 more source

A Randomized Double‐Blind, Placebo‐Controlled Trial of Artesunate and Curcumin in Patients With Crohn's Disease: A Pilot Study

JGH Open, Volume 9, Issue 7, July 2025.
ABSTRACT Aim Less than half of all patients with Crohn's disease remain in remission with long‐term use of azathioprine. Our aim was to assess the efficacy of Artesunate and Curcumin in maintaining remission in patients with Crohn's disease, who had ongoing evidence of disease activity despite taking azathioprine.
Devinder Kumar, Uday C Ghoshal, Vamika Mansi Saigal, Moni Chaudhary, Shikha Sahu, Vishruti Pandya, Ujjala Ghoshal   +6 more
wiley   +1 more source

"We learn from them, they learn from us": global health experiences and host perceptions of visiting health care professionals.

, 2013
PURPOSE: It is increasingly common for health care professionals from developed countries to travel to developing regions of the world to learn or teach.
Drain, Drain, Izadnegahdar, Kolars, Miller, Pinto, Suchdev   +6 more
core   +1 more source

Mitochondria‐Associated Endoplasmic Reticulum Membranes in Human Health and Diseases

MedComm, Volume 6, Issue 7, July 2025.
MAM dysfunction is considered as an initiator or contributor in the progression of various diseases such as nervous system diseases, circulatory system diseases, digestive system diseases, locomotor system diseases, reproductive system diseases, endocrine system diseases, urinary system diseases, respiratory system diseases and cancer.
Yong Liu, Zi‐Hui Mao, Junwen Huang, Hui Wang, Xiao Zhang, Xin Zhou, Yue Xu, Shaokang Pan, Dongwei Liu, Zhangsuo Liu, Qi Feng   +10 more
wiley   +1 more source

Purified E255L Mutant SERCA1a and Purified PfATP6 Are Sensitive to SERCA-type Inhibitors but Insensitive to Artemisinins*

Journal of Biological Chemistry, 2010
The antimalarial drugs artemisinins have been described as inhibiting Ca2+-ATPase activity of PfATP6 (Plasmodium falciparum ATP6) after expression in Xenopus oocytes.
Delphine Cardi, A. Pozza, B. Arnou, Estelle Marchal, J. D. Clausen, J. Andersen, S. Krishna, J. Møller, M. le Maire, C. Jaxel   +9 more
semanticscholar   +1 more source

Identification of a New Chemical Class of Antimalarials [PDF]

, 2017
The increasing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with novel modes of action (MOAs). Here, we describe a compound representative of a new class of antimalarials.
Aissaoui, Hamed, Binkert, Christoph, Boss, Christoph, Bozdech, Zbynek, Brun, Reto, Brunner, Ralf, Corminboeuf, Olivier, Delahaye, Stephane, Fischli, Christoph, Heidmann, Bibia, Kaiser, Marcel, Kamber, Jolanda, Meyer, Solange, Papastogiannidis, Petros, Siegrist, Romain, Voss, Till, Welford, Richard, Wittlin, Sergio   +17 more
core  

Role of LEAFLESS, an AP2/ERF family transcription factor, in the regulation of trichome specialized metabolism

New Phytologist, Volume 247, Issue 2, Page 774-790, July 2025.
Summary Acylsugars, specialized metabolites produced by trichomes of many solanaceous species, provide protection against biotic and abiotic stresses. Many acylsugar metabolic enzymes have been identified; however, regulatory factors remain unknown.
Sabyasachi Mandal, Yohannes H. Rezenom, Thomas D. McKnight   +2 more
wiley   +1 more source