Results 101 to 110 of about 15,257 (261)
Plant Biotechnology Journal, EarlyView.ABSTRACT Tanshinones, the major bioactive diterpenes in Salvia miltiorrhiza Bunge, are widely used to treat cardiovascular and cerebrovascular diseases. While jasmonates (JAs) are known to modulate tanshinones accumulation, the molecular link between JA signalling and tanshinone biosynthesis remains unclear.
Renjun Qu +9 more
wiley +1 more source
Production and characterization of different types of malaria pigment (hemozoin) and their potential use for screening for hemozoin inhibiting drugs [PDF]
, 2012 Tese de mestrado. Biologia (Microbiologia Aplicada). Universidade de Lisboa, Faculdade de Ciências, 2012Malarial pigment, hemozoin, appears to modulate the immune system, however it remains controversial if it has stimulatory or inhibitory effects ...
Góis, Ana Margarida Ferreira, 1988-
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Anti-malarial drug artesunate restores metabolic changes in experimental allergic asthma [PDF]
, 2016 The anti-malarial drug artesunate possesses anti-inflammatory and anti-oxidative actions in experimental asthma, comparable to corticosteroid. We hypothesized that artesunate may modulate disease-relevant metabolic alterations in allergic asthma.
Cheng, Chang +8 more
core +1 more source
How to tackle antimalarial resistance?
EMBO Molecular Medicine, 2016 Graphical Abstract In the context of drug resistance, malaria is no exception. Even the latest artemisinins have started to lose their full efficacy in patients.
Didier Leroy
doaj +1 more source
Elimination of Schistosoma mansoni in infected mice by slow release of artemisone
International Journal for Parasitology: Drugs and Drug Resistance, 2017 The current treatment of schistosomiasis is based on the anti-helminthic drug praziquantel (PZQ). PZQ affects only the adult stages of schistosomes. In addition, resistance to PZQ is emerging.
Daniel Gold +10 more
doaj +1 more source
Molecular Basis of Artemisinin Derivatives Inhibition of Myeloid Differentiation Protein 2 by Combined in Silico and Experimental Study [PDF]
, 2021 Sennan Qiao +3 more
openalex +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Plant glandular trichomes (GTs) are characterised by their ability to synthesise and store abundant secondary metabolites of significant biological importance. The medicinal plant Artemisia argyi exhibits a dense covering of GTs, yet the precise metabolic compositions and the developmental molecular dynamics of A.
Shuting Dong +6 more
wiley +1 more source
The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica [PDF]
, 2017 Objectives: The trematocidal properties of a synthetic peroxide, 1,2,4-trioxolane (OZ78) were determined both in vivo and in vitro. Methods: Two weeks post-infection Echinostoma caproni-infected mice were administered single oral doses of 400-1000 mg/kg ...
Dong, Yuxiang +4 more
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Plant Biotechnology Journal, EarlyView.ABSTRACT Artemisinin, an antimalarial sesquiterpene lactone, is biosynthesized in glandular trichomes of Artemisia annua. Although numerous transcription factors have been demonstrated to regulate artemisinin biosynthesis, the molecular mechanisms underlying the high expression of artemisinin‐associated biosynthetic enzyme and transcription factor ...
Xueqing Fu +11 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Plants are promising bioreactor for the sustainable and scalable production of high‐value natural bioactive compounds, because they can synthesise phytochemicals from CO2, light, water and minerals through their innate photosynthetic carbon assimilation machinery.
Xuan Sun +8 more
wiley +1 more source