Results 111 to 120 of about 8,416 (212)
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria [PDF]
, 2015 Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatens future malaria control and elimination on a global ...
Bhattacharjee, Souvik +18 more
core +2 more sources
British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 317-322, January 2026.In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline proportionally during treatment ...
Meg K. Tully +3 more
wiley +1 more source
Artemisinins and synthetic peroxides as highly efficient antimalarials
Macedonian Journal of Chemistry and Chemical Engineering, 2012 Malaria is devastating disease and global public health problem, with nearly half world population exposed to risk. Illness is caused by five Plasmodium species, P. falciparum, P. ovale, P. vivax, P. malarie and P. knowlesi, from which P.
Dejan Milos Opsenica +1 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 1, January 2026.Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco +11 more
wiley +1 more source
World Journal of Traditional Chinese Medicine, 2016 The interest of Western medicine in Traditional Chinese Medicine (TCM) as a source of drug leads/new drugs to treat diseases without available efficient therapies has been dramatically augmented in the last decades by the extensive work and the ...
Thomas Efferth +9 more
doaj +1 more source
World Antimalarial Resistance Network (WARN) III: Molecular Markers for Drug Resistant Malaria [PDF]
, 2010 Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Barnwell, John W +14 more
core +2 more sources
ChemMedChem, Volume 21, Issue 1, January 2026.Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri +14 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 1, January 2026.Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli +8 more
wiley +1 more source
International Journal of Infectious Diseases, 2014 Background: Artemisinin derivatives are the mainstay of antimalarial treatment, both for uncomplicated malaria and for severe disease. Artemisinins are known for their rapid onset of action, good tolerability, and safety.
Khalid Rehman +3 more
doaj +1 more source
Efficacy and Safety of Mefloquine, Artesunate, Mefloquine-Artesunate, and Praziquantel against Schistosoma haematobium: Randomized, Exploratory Open-Label Trial [PDF]
, 2017 Background. Morbidity control of schistosomiasis relies on a single drug, praziquantel. The antimalarial drug mefloquine possesses interesting antischistosomal properties, yet no clinical studies have been performed. Methods.
Adoubryn, Koffi D. +7 more
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