Results 111 to 120 of about 15,257 (261)
Identification of a New Chemical Class of Antimalarials [PDF]
, 2017 The increasing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with novel modes of action (MOAs). Here, we describe a compound representative of a new class of antimalarials.
Aissaoui, Hamed +17 more
core
Cannabis‐Derived Compounds Against Plasmodium sp.: A Systematic Review of Preclinical Studies
Tropical Medicine &International Health, EarlyView.ABSTRACT Objective This study aims to evaluate preclinical studies on the effects and toxicity of cannabis‐derived compounds against Plasmodium sp. Methods A literature search was conducted in Web of Science, PubMed, Scopus and LILACS databases until December 2024. Studies that assessed the activity or toxicity of cannabis against Plasmodium sp.
Tácio de Mendonça Lima +5 more
wiley +1 more source
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria [PDF]
, 2015 Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatens future malaria control and elimination on a global ...
Bhattacharjee, Souvik +18 more
core +2 more sources
Molecular Markers of Antimalarial Drug Resistance in Plasmodium falciparum From Kumasi, Ghana, 2023
Tropical Medicine &International Health, EarlyView.ABSTRACT Objectives Artemisinin partial resistance has emerged in East Africa and is feared to spread across the continent, potentially compromising artemisinin‐based combination treatment. Molecular markers can serve as early warning signals for the development of specific drug resistance.
Albert Dennis Kegya +10 more
wiley +1 more source
Artemisinins and synthetic peroxides as highly efficient antimalarials
Macedonian Journal of Chemistry and Chemical Engineering, 2012 Malaria is devastating disease and global public health problem, with nearly half world population exposed to risk. Illness is caused by five Plasmodium species, P. falciparum, P. ovale, P. vivax, P. malarie and P. knowlesi, from which P.
Dejan Milos Opsenica +1 more
doaj +1 more source
Artemisinin-based combinations
Current Opinion in Infectious Diseases, 2005 Artemisinin-based combination treatments have been the mainstay of treatment for falciparum malaria in Southeast Asia for more than 10 years and are now increasingly recommended as first-line treatment throughout the rest of the world.A large multicentre randomised trial conducted in East Asia has shown a 35% reduction in mortality from severe malaria ...
Ashley, E, White, N
openaire +3 more sources
Food Frontiers, Volume 7, Issue 1, January 2026.Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli +8 more
wiley +1 more source
World Journal of Traditional Chinese Medicine, 2016 The interest of Western medicine in Traditional Chinese Medicine (TCM) as a source of drug leads/new drugs to treat diseases without available efficient therapies has been dramatically augmented in the last decades by the extensive work and the ...
Thomas Efferth +9 more
doaj +1 more source
Acyclic Nucleoside Phosphonates As Potential Inhibitors of Plasmodium Falciparum Egress
Chemistry – A European Journal, Volume 31, Issue 69, December 9, 2025.Exploration of the chemistry of acyclic nucleoside phosphonates allowed us to study structural diversity from the hit compound; biological evaluation and molecular docking were performed to decipher key interactions with the putative target. Abstract The emergence of drug‐resistant Plasmodium strains requires the development of novel antimalarial ...
Thomas Cheviet +6 more
wiley +1 more source