Results 81 to 90 of about 8,416 (212)

Malaria: an update on treatment of adults in non-endemic countries. [PDF]

, 2006
Every year people die from malaria in Britain and other industrialised countries. Most of these deaths are avoidable: they occur because a patient or doctor has underestimated the severity of the disease or has not considered the diagnosis early enough ...
Lalloo, David, Ustianowski, Andrew, Whitty, Christopher JM   +2 more
core   +2 more sources

Jasmonate‐Activated AaWRKY9–AabHLH93/AabHLH93–AaMYB7 Complexes Balance Artemisinin Biosynthesis in Artemisia annua

Plant Biotechnology Journal, EarlyView.
ABSTRACT Artemisinin, an antimalarial sesquiterpene lactone, is biosynthesized in glandular trichomes of Artemisia annua. Although numerous transcription factors have been demonstrated to regulate artemisinin biosynthesis, the molecular mechanisms underlying the high expression of artemisinin‐associated biosynthetic enzyme and transcription factor ...
Xueqing Fu, Han Zheng, Yaojie Zhang, Muyao Yu, Shu Li, Hang Liu, Pin Liu, Ling Li, Xiaofen Sun, Jingya Zhao, Yuliang Wang, Kexuan Tang   +11 more
wiley   +1 more source

Severe Embryotoxicity of Artemisinin Derivatives in Experimental Animals, but Possibly Safe in Pregnant Women

Molecules, 2009
Preclinical studies in rodents have demonstrated that artemisinins, especially injectable artesunate, can induce fetal death and congenital malformations at a low dose range.
Qigui Li, Peter J. Weina
doaj   +1 more source

Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review [PDF]

, 2018
Increasing drug resistance in gastrointestinal (GI) parasites of livestock and concerns about chemical residues in animal products and the environment are driving the development of alternative control strategies that are less reliant on the use of ...
Boas, Ulrik, Enemark, Heidi L., López-Muñoz, Rodrigo, Peña-Espinoza, Miguel, Simonsen, Henrik T., Thamsborg, Stig M., Valente, Angela H., Williams, Andrew R.   +7 more
core   +4 more sources

Artemisinin

HIMALAYA, 2019
Malaria is a disease that has blighted humankind since early times. The first antimalarial treatment available to Europeans was the dried bark of the cinchona tree from Peru. The main problem in its use was adulteration by other material. The ‘active principle’ was first extracted in 1820 and named quinine.
openaire   +1 more source

Heterologous Production of Forskolin in Tobacco (Nicotiana tabacum) via Glandular Trichome Specific Engineering and Metabolic Flux Redirection

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plants are promising bioreactor for the sustainable and scalable production of high‐value natural bioactive compounds, because they can synthesise phytochemicals from CO2, light, water and minerals through their innate photosynthetic carbon assimilation machinery.
Xuan Sun, Xiuming Wu, Xun Jiang, Hongmei Huang, Aiguo Yang, Yiting Li, Zhenjun Fan, Aixia Chang, Changqing Yang   +8 more
wiley   +1 more source

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials [PDF]

, 2014
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites.
Bringela, A., Chadwick, J., Copple, I. M., Cristiano, Maria Lurdes Santos, Donegan, G., Firman, J., Herpers, B., Mercer, A. E., O'Neill, Paul M., Park, B. K., Van De Water, B., Ward, Stephen A., Wong, M. H.   +12 more
core  

Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells. [PDF]

, 2014
In parts of Africa and Asia, self-medication with a hot water infusion of Artemisia annua (Artemisia tea) is a common practice for a number of ailments including malaria and cancer.
Ahn, Bandyopadhyay, Belkaid, Berger, Blanke, Carbonara, Chen, Chirnomas, De Donno, de Magalhães, Dell′Eva, Efferth, Efferth, Efferth, Feng, Ferlay, Florea, Galluzzi, Gravett, Heide, Hsiao, Hsu, Isikdag, Jin, Kono, Kooy, Lai, Lee, Li, Liu, Mercer, Miketova, Mouton, Nemeikaitė-Čėnienė, Nobili, Noratto, Paluszczak, Psotová, Rath, Reungpatthanaphong, Sadava, Siddik, Singh, Sirchia, Suberu, Suberu, Tegze, van Huijsduijnen, Vichai, Wang, Willcox, Williamson, Williamson, Wright, Wu, Zhang   +55 more
core   +5 more sources

Plastid Engineering for Photosynthesis‐Driven Synthesis of Hyaluronic Acid in Tobacco

Plant Biotechnology Journal, EarlyView.
ABSTRACT Hyaluronic acid (HA) is a glycosaminoglycan composed of alternating units of N‐acetylglucosamine and glucuronic acid. High moisture retention, viscoelasticity and biocompatibility are unique features that make HA polymers attractive compounds for medical applications and aesthetic purposes.
Amanda Lopes, Omar Sandoval‐Ibáñez, Stéphanie Arrivault, David Rolo, F. Vanessa Loiacono, Alexander Erban, Daniel Karcher, Stephan Obst, Stephanie Ruf, Joachim Kopka, Ralph Bock   +10 more
wiley   +1 more source

Artemisinin-based combinations

Current Opinion in Infectious Diseases, 2005
Artemisinin-based combination treatments have been the mainstay of treatment for falciparum malaria in Southeast Asia for more than 10 years and are now increasingly recommended as first-line treatment throughout the rest of the world.A large multicentre randomised trial conducted in East Asia has shown a 35% reduction in mortality from severe malaria ...
Ashley, E, White, N
openaire   +3 more sources