Results 81 to 90 of about 15,257 (261)

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, EarlyView.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Safety of Artemether-Lumefantrine Exposure in First Trimester of Pregnancy: An Observational Cohort. [PDF]

, 2014
There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies ...
AM Dondorp, B Cheng, Blaise Genton, C Everett, C Manyando, CfDER, D Parker, DE Meier, Dominic Mosha, E Rutta, Esperanca Sevene, Festo Mazuguni, G Lefevre, I Adam, J Okombo, JP Maxwell, M Desai, Ministry of Health of Tanzania, NN Lufesi, O David, P Piola, R Mbwasi, RW Steketee, S Dellicour, Salim Abdulla, SC McCombie, Sigilbert Mrema, Statistics TNBo, TE White, Twaweza, WHO, WHO, WHO   +32 more
core   +4 more sources

Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination

Parasite, 2018
The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin derivative with a partner drug, in the treatment of uncomplicated malaria has largely been responsible for the significant reduction in malaria-related mortality in ...
Ouji Manel, Augereau Jean-Michel, Paloque Lucie, Benoit-Vical Françoise   +3 more
doaj   +1 more source

Healthcare provider and drug dispenser knowledge and adherence to guidelines for the case management of malaria in pregnancy in the context of multiple first-line artemisinin-based combination therapy in western Kenya [PDF]

, 2023
Caroline B. Osoro, Stephanie Dellicour, Eleanor Ochodo, Taryn Young, Feiko O. ter Kuile, Julie Gutman, Achille Massougbodji   +6 more
openalex   +1 more source

Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

Exploration, EarlyView.
1. Caffeic acid (CA) is a novel senomorphic. 2. Annexin A5 is the direct protein target of CA in senescent cells. 3. The covalent binding of CA to Annexin A5 protein triggers its degradation, PKCθ deactivation, and the inhibition of the NF‐κB inflammatory pathway. 4. CA effectively alleviates inflammation and lung fibrosis in mouse model.
Yinhua Zhu, Ying Zhang, Qianyu Zhang, Ping Song, Junzhe Zhang, Ang Ma, Chen Wang, Peng Gao, Tong Yang, Lirun Zhou, Qiaoli Shi, Yin Kwan Wong, Yongting Luo, Huan Tang, Jigang Wang   +14 more
wiley   +1 more source

Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children. [PDF]

, 2016
BACKGROUND: Studies in Southeast Asia reported a strong relationship between polymorphisms at the propeller domain of the Kelch 13 (K13) protein encoded by the Plasmodium falciparum k13 (pfk13) gene and delayed parasite clearance after artemisinin ...
Beshir, Khalid B, Bousema, Teun, Henriques, Gisela, Muwanguzi, Julian, Sawa, Patrick, Sutherland, Colin J   +5 more
core   +2 more sources

Severe Embryotoxicity of Artemisinin Derivatives in Experimental Animals, but Possibly Safe in Pregnant Women

Molecules, 2009
Preclinical studies in rodents have demonstrated that artemisinins, especially injectable artesunate, can induce fetal death and congenital malformations at a low dose range.
Qigui Li, Peter J. Weina
doaj   +1 more source

Single‐cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease

iMeta, EarlyView.
A clinical study reported that Abelmoschus manihot (L.) Medic (A. manihot), in the form of Huangkui capsule (HKC), combined with irbesartan (IRB) is an effective therapy for patients with diabetic kidney disease (DKD). The bioactive components of HKC are total flavones extracted from A. manihot (TFA).
Chenhua Wu, Haitao Tang, Yihong Yu, Yuhui Song, Haitao Ge, Yiming Shen, Jie Wu, Harvest F. Gu   +7 more
wiley   +1 more source

Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells. [PDF]

, 2014
In parts of Africa and Asia, self-medication with a hot water infusion of Artemisia annua (Artemisia tea) is a common practice for a number of ailments including malaria and cancer.
Ahn, Bandyopadhyay, Belkaid, Berger, Blanke, Carbonara, Chen, Chirnomas, De Donno, de Magalhães, Dell′Eva, Efferth, Efferth, Efferth, Feng, Ferlay, Florea, Galluzzi, Gravett, Heide, Hsiao, Hsu, Isikdag, Jin, Kono, Kooy, Lai, Lee, Li, Liu, Mercer, Miketova, Mouton, Nemeikaitė-Čėnienė, Nobili, Noratto, Paluszczak, Psotová, Rath, Reungpatthanaphong, Sadava, Siddik, Singh, Sirchia, Suberu, Suberu, Tegze, van Huijsduijnen, Vichai, Wang, Willcox, Williamson, Williamson, Wright, Wu, Zhang   +55 more
core   +5 more sources

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source