Results 61 to 70 of about 17,563,378 (284)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Doppler de arteria cerebral media: la mejor prueba para el diagnóstico y seguimiento de la anemia fetal [PDF]

, 2005
ResumenLa insoinmunización a las células saguíneas permanece como una de las más comunes causas de la anemia fetal.
Salazar, Hernando A
core   +1 more source

Pronóstico de las oclusiones del segmento m2 de la arteria cerebral media tratadas con trombectomía mecánica [PDF]

, 2021
El ictus isquémico constituye un problema socio-sanitario de primera magnitud en todo el mundo. En nuestro país, el ictus supone la primera causa de discapacidad física en adultos y la segunda causa de demencia (1).
Terroba Baizán, Cristina
core  

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Drenaje ventricular externo en el infarto completo de la arteria cerebral media

Revista de Neurología, 2003
Introduccion. La hipertension intracraneal grave debida al infarto de todo el territorio de la arteria cerebral media responde mal al tratamiento medico y, a menudo, le sigue una herniacion transtentorial y la muerte. Recientemente se han publicado buenos resultados tras la practica de una hemicraniectomia descompresiva en estos casos.
Ana Belén Pinel González, Carmen Muñoz Fernández, María Jesús Alemany Rodríguez, Jesús Morera Molina, Santiago Lubillo Montenegro   +4 more
openaire   +2 more sources

Lesão penetrante do crânio pela via transnasal: Relato de caso

Brazilian Neurosurgery, 2008
Lesões penetrantes no crânio são incomuns pela via transnasal e geralmente ocorrem como resultado de violência, acidentes de trabalho, de trânsito, ou por um evento casual. Este relato trata de introdução acidental de barra de metal, por uma das narinas,
José Weber Vieira de Faria, Carlos Uderson de Alarcão Cariso, Daniel Andrade Diniz, Erick Menezes Xavier, Júlio César da Fonseca Marra, Natássia de Oliveira Lawal   +5 more
doaj   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

[Middle cerebral artery stroke due to paradoxical embolism in a patient with COVID-19 pneumonia]. [PDF]

Rev Esp Cardiol, 2021
Pons-Pellicé L, Camio-Visauta E, Chocron-Da Prat I, Rodríguez-Palomares JF, Rosés Noguer F, de Nadal M.   +5 more
europepmc   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source