Results 71 to 80 of about 2,329 (276)

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Anastomose arterial extra-intracraniana para tratamento de paciente com isquemia cerebral refratária ao manejo clínico

Arquivos de Neuro-Psiquiatria, 2004
A anastomose extra-intracraniana pode ser utilizada em casos selecionados de insuficiência vascular encefálica refratária ao tratamento clínico. Descrevemos um caso de isquemia encefálica em território de artéria cerebral média direita devida à oclusão ...
Falavigna Asdrubal, Ferraz Fernando Antonio Patriani, Breunig Juliano de Avelar, Michelin Marja Mandelli   +3 more
doaj  

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Análise crítica e comentários acerca da craniectomia descompressiva no tratamento da hipertensão intracraniana refratária decorrente de isquemia no território da artéria cerebral média

, 2018
Introducao: A hipertensao intracraniana refrataria secundaria ao infarto do territorio da arteria cerebral media ainda hoje representa uma complexa questao neurocirurgica.
Paulo Henrique Auiar, Ricardo B. V. Fontes, R. Simm, M. C. Montenegro, C. Petitto, S. Faria, Roberto Hirsch   +6 more
semanticscholar   +1 more source

Aneurisma Fusiforme Disecante de la Arteria Cerebral Media Tratado con Resección Más Bypass Extra-Intracraneano. Reporte de caso y revisión del tema

JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA, 2019
Introducción: Las lesiones arteriales aneurismáticas cobran gran relevancia hoy en día ya que si se realiza un diagnóstico precoz se puede prevenir la rotura de las mismas. Aneurisma no roto o grado 0 se define a aquel que no sangro.
Alejandra Jaume, Mariana Romero, Matías Negrotto, P. Pereda, E. Spagnuolo, J. Mura   +5 more
semanticscholar   +1 more source

Origem e territorio de distribuição da artéria cerebral média em javali (Sus scrofa scrofa Linnaeus, 1758)

Bioscience Journal, 2014
Foram estudados 20 encéfalos de javali (Sus scrofa scrofa), adultos, 14 fêmeas e oito machos, com o sistema arterial corado com látex e fixados por solução aquosa de formaldeído a 10%.
Flávio Machado Moraes, André Luiz Quagliatto Santos   +1 more
doaj   +2 more sources

A Steerable and Expandable Magnetic Aspiration Catheter for Enhanced Aspiration Thrombectomy

Advanced Intelligent Systems, EarlyView.
This article presents a novel magnetic aspiration catheter (MAC) that can be both actively steered and undergo distal‐end expansion via externally applied magnetic fields. The MAC facilitates precise branch selection and enhances clot engagement by improving endovascular navigation and aspiration efficiency. Phantom experiments validate its feasibility
Hakjoon Lee, Xiao Dong, Dong‐in Kim, A. M. Masum Bulbul Chowdhury, Nader Latifi Gharamaleki, Jin‐young Kim, Sung Won Youn, Hongsoo Choi   +7 more
wiley   +1 more source

Considerações clínicas e cirúrgicas sobre aneurismas intracranianos Clinical and surgical considerations on intracranial aneurysms

Arquivos de Neuro-Psiquiatria, 1969
São revistos os principais sintomas apresentados por 83 pacientes com aneurismas intracranianos nas seguintes localizações: 41 no sistema carotídeo, 19 no da artéria silviana, 19 no da artéria cerebral anterior e 4 no da artéria basilar.
Mário S. Cademartori
doaj  

Outcomes of decompressive craniectomy for malignant middle cerebral artery stroke in an academic hospital in Brazil. [PDF]

Arq Neuropsiquiatr, 2023
Rodrigues de Oliveira LF, Camilo MR, Franciscatto L, Podolsky-Gondim GG, Alves FFA, Filho RKDVM, Dias FA, Tanaka K, Colli BO, Pontes-Neto OM.   +9 more
europepmc   +1 more source