Results 51 to 60 of about 10,758,011 (382)

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Stages of health behavior change and factors associated with physical activity in patients with intermittent claudication [PDF]

, 2012
OBJECTIVE: To analyze, in people with intermittent claudication, the frequency of individuals who are in each of stages of health behavior change to practice physical activity, and analyze the association of these stages with the walking capacity ...
Barbosa, João Paulo dos Anjos Souza, Chehuen, Marcel da Rocha, Cucato, Gabriel, Dias, Raphael Mendes Ritti, Farah, Breno Quintella, Forjaz, Cláudia Lúcia de Moraes, Oliveira, Jacilene Guedes de, Wolosker, Nelson   +7 more
core   +2 more sources

Peripheral Arterial Disease

South African Family Practice, 2004
Peripheral arterial disease (PAD) is a common disease. One in five of the middle-aged population of the United Kingdom has evidence of peripheral vascular disease on clinical examination, although only a quarter of these people have symptoms1.
A.T.O. Abdool-Carrim
doaj   +1 more source

Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study. [PDF]

PLoS ONE, 2013
BACKGROUND: This study aimed to determine the prevalence of genetic and environmental vascular risk factors in non diabetic patients with premature peripheral arterial disease, either peripheral arterial occlusive disease or thromboangiitis obliterans ...
Annie M Bérard, Aurélie Bedel, Rémi Le Trequesser, Geneviève Freyburger, Alan Nurden, Sylvie Colomer, Viviane Guérin, Marie-Christine Vergnes, François Becker, Gabriel Camelot, Luc Bressolette, Philippe Lacroix, Jean-Pierre Cambou, Alessandra Bura-Rivière, Joseph Emmerich, Michel Darmon, Anne-Marie Deletraz, Samir Mesli, Brigitte Colombies, Virginie Vanbrugghe, Claude Conri, Joël Constans   +21 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Secondhand smoke exposure and risk of incident peripheral arterial disease and mortality: a Scotland-wide retrospective cohort study of 4045 non-smokers with cotinine measurement [PDF]

, 2018
Background: Active smoking is an important risk factor for all-cause mortality and peripheral arterial disease (PAD). In contrast, published studies on the associations with secondhand smoke (SHS) are limited.
Lu, Liya, Mackay, Daniel F., Pell, Jill P.   +2 more
core   +1 more source

Usual blood pressure, peripheral arterial disease, and vascular risk: cohort study of 4.2 million adults

British medical journal, 2015
Objectives To determine the subgroup specific associations between usual blood pressure and risk of peripheral arterial disease, and to examine the relation between peripheral arterial disease and a range of other types of vascular disease in a large ...
C. Emdin, S. Anderson, T. Callender, N. Conrad, G. Salimi-Khorshidi, H. Mohseni, M. Woodward, K. Rahimi   +7 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

An Update on Methods for Revascularization and Expansion of the TASC Lesion Classification to Include Below-the-Knee Arteries: A Supplement to the Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II): The TASC Steering Comittee(.).

Annals of Vascular Diseases, 2015
The Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC) guidelines were last updated in 2007 (TASC II) and represented the collaboration of international vascular specialties involved in the management of patients with ...
M. Jaff, C. White, W. Hiatt, G. Fowkes, J. Dormandy, M. Razavi, J. Reekers, L. Norgren   +7 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source