Results 141 to 150 of about 66,223 (392)

Measuring Knee Bone Marrow Perfusion Using Arterial Spin Labeling at 3 T [PDF]

, 2020
Xiufeng Li, Casey P. Johnson, Jutta Ellermann   +2 more
openalex   +1 more source

Modulation Effects of Repeated Transcranial Direct Current Stimulation at the Dorsolateral Prefrontal Cortex: A Pulsed Continuous Arterial Spin Labeling Study [PDF]

, 2023
Valeria Saccà, Nasim Maleki, Ya Wen, Sierra Hodges, Jian Kong   +4 more
openalex   +1 more source

Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: A longitudinal arterial spin labeling study [PDF]

, 2016
Objective Frontotemporal dementia (FTD) is characterized by behavioral disturbances and language problems. Familial forms can be caused by genetic defects in microtubule-associated protein tau (MAPT), progranulin (GRN), and C9orf72.
Chalos, V. (Vicky), Dopper, E.G.P. (Elise), Ghariq, E. (Eidrees), Hafkemeijer, A. (Anne), Heijer, T. (Tom) den, Jiskoot, L.C. (Lize), Koning, I. (Inge) de, Osch, M.J.P. (Matthias J.) van, Rombouts, S.A.R.B. (Serge), Seelaar, H. (Harro), Swieten, J.C. (John) van, Thornton, A.S. (Andrew)   +11 more
core   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Neuroimaging as a selection tool and endpoint in preclinical and clinical trials [PDF]

, 2016
Standard imaging in acute stroke enables the exclusion of non-stroke structural CNS lesions and cerebral haemorrhage from clinical and pre-clinical ischaemic stroke trials. In this review, the potential benefit of imaging (e.g., angiography and penumbral
Macrae, I. Mhairi, Muir, Keith W.
core   +2 more sources

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Deep Learning Detection of Penumbral Tissue on Arterial Spin Labeling in Stroke

Stroke, 2019
Supplemental Digital Content is available in the text. Background and Purpose— Selection of patients with acute ischemic stroke for endovascular treatment generally relies on dynamic susceptibility contrast magnetic resonance imaging or computed ...
Kai Wang, Qinyang Shou, Samantha J. Ma, D. Liebeskind, Xin J. Qiao, J. Saver, N. Salamon, Hosung Kim, Yannan Yu, Yuan Xie, G. Zaharchuk, F. Scalzo, Danny J. J. Wang   +12 more
semanticscholar   +1 more source

Quantitative myocardial perfusion in mice based on the signal intensity of flow sensitized CMR

Journal of Cardiovascular Magnetic Resonance, 2012
Background In the conventional approach to arterial spin labeling in the rodent heart, the relative difference in the apparent T1 relaxation times corresponding to selective and non-selective inversion is related to perfusion via a two compartment model ...
Abeykoon Sumeda, Sargent Michelle, Wansapura Janaka P   +2 more
doaj   +1 more source

PRELIMINARY ANALYSIS OF BRAIN PERFUSION OBTAINED WITH ARTERIAL SPIN LABELING METHOD (ASL) USED TO EVALUATE THE EFFECTS OF TYPE 2 DIABETES IN MORBIDLY OBESE PATIENTS

, 2023
Anna Kędziora, Michał Kacprzak, Ewa Piątkowska-Janko   +2 more
openalex   +2 more sources