Results 71 to 80 of about 13,023 (262)

Differentiating the Clinical and Variant Spectrum of Hardikar Syndrome From Other MED12‐Related Developmental Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The rare X‐linked female‐restricted Hardikar syndrome (HDKR, OMIM # 301068) is characterized by multiple congenital anomalies including orofacial clefts, gastrointestinal, genitourinary, and cardiac anomalies, but cognitive and neurobehavioral development is rarely impaired.
Tinne Warmoeskerken, Miel Theunis, Kris Van den Bogaert, Koenraad Devriendt, Jeroen Breckpot   +4 more
wiley   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection‐on‐a‐Chip Model

Advanced NanoBiomed Research, EarlyView.
Lysyl oxidase crosslinking of type I collagen decreases neutrophil extravasation through an endothelium during the initial response to P. aeruginosa. This decrease in extravasation is likely due to the increase in VE‐cadherin expression between endothelial cells seeded on LOX‐crosslinked collagen hydrogels.
Christopher J. Calo, Tanvi Patil, Josephine Fouts, Eric L. Ginter, Margaret Radke, Hannah K. Weppner, Justin M. Owens, Laurel E. Hind   +7 more
wiley   +1 more source

3D anatomical atlas of the heads of male and female adult Chamaeleo calyptratus

The Anatomical Record, EarlyView.
The veiled chameleon is a model organism in reptile development research. Utilizing contrast‐enhanced microCT and deep learning segmentation models, we have generated the first digital atlases of the skull, nervous system, cranial muscles and hyolingual muscles.
Alice Leavey, Eloy Gálvez‐López, Anthony Herrel, Laura B. Porro   +3 more
wiley   +1 more source

Next Generation 7 Tesla Arterial Spin Labeling With Rotated Spiral Acquisition Enables Mesoscale Resolution in 3D Brain Perfusion and Functional MRI. [PDF]

Magn Reson Med
ABSTRACT Purpose To achieve high resolution (≤ 1 mm isotropic) whole‐brain perfusion imaging at 7 T with next generation ASL pulse sequence, reconstruction algorithm, and MRI hardware. Methods We capitalized on three major innovations: (1) FLASH‐based pseudo‐Continuous ASL (pCASL) sequence with rotated golden‐angle stack‐of‐spirals (rGA‐SoS) sampling; (
Zhao C, Guo F, Yang Z, Shao X, Ma SJ, Beckett AJS, Vu AT, Feinberg DA, Wang DJJ.   +8 more
europepmc   +2 more sources

Crossed cerebellar diaschisis in status epilepticus: A systematic review of the literature

Epileptic Disorders, EarlyView.
Abstract Objective Crossed cerebellar diaschisis is a neuroimaging phenomenon observed in various neurological conditions, including status epilepticus. This systematic review aims to summarize the clinical and radiological characteristics of patients developing crossed cerebellar diaschisis following status epilepticus and to discuss potential ...
Payam Tabaee Damavandi, Pilar Bosque‐Varela, Helena Barbosa Horta Santos, Bassam Al‐Fatly, Lukas Machegger, Eugen Trinka, Giorgi Kuchukhidze   +6 more
wiley   +1 more source

Ictal–interictal continuum and status epilepticus: Two sides of the same coin? A prospective magnetic resonance imaging study

Epilepsia, EarlyView.
Abstract Objective Status epilepticus (SE) is the most severe expression of seizures, encompassing both SE with prominent motor symptoms and nonconvulsive SE (NCSE). Ictal–interictal continuum (IIC), an electroencephalographic phenomenon, is characterized by periodic discharges (PD), spike‐and‐waves or sharp‐and‐waves (SW), or lateralized rhythmic ...
Pilar Bosque‐Varela, Lukas Machegger, Wanda Lauth, Panagiota Eleni Tsalouchidou, Susanne Knake, Georg Zimmermann, Nicolas Jannone‐Pedro, Giada Giovannini, Stefano Meletti, Adrian Ridski Harsono, Fabio Rossini, Markus Leitinger, Johannes Pfaff, Sándor Beniczky, Eugen Trinka, Giorgi Kuchukhidze   +15 more
wiley   +1 more source

Quantitative myocardial perfusion in mice based on the signal intensity of flow sensitized CMR

Journal of Cardiovascular Magnetic Resonance, 2012
Background In the conventional approach to arterial spin labeling in the rodent heart, the relative difference in the apparent T1 relaxation times corresponding to selective and non-selective inversion is related to perfusion via a two compartment model ...
Abeykoon Sumeda, Sargent Michelle, Wansapura Janaka P   +2 more
doaj   +1 more source

Arterial spin labeling performs comparably to 2‐[18F]fluoro‐2‐deoxy‐D‐glucose positron emission tomography for presurgical evaluation in pediatric lesional epilepsy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to test whether arterial spin labeling (ASL) performs comparably to 2‐[18F]fluoro‐2‐deoxy‐D‐glucose positron emission tomography (FDG‐PET), the mainstay functional imaging technique, in pediatric lesional epilepsy, while avoiding radiotracer exposure and additional sedation.
Antonio Giulio Gennari, Dorottya Cserpan, Raimund Kottke, Niklaus Krayenbühl, Michael Messerli, Martin W. Hüllner, Ruth O'Gorman Tuura, Georgia Ramantani   +7 more
wiley   +1 more source

Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications

Exploration, EarlyView.
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu, Yi Li, Hulin Long, Yijia Wu, Ningwei Sun, Shun Li, Yiyao Liu, Huiqi Xie, Ji Bao   +8 more
wiley   +1 more source