Results 111 to 120 of about 127,842 (275)

Survodutide for treatment of obesity: Baseline characteristics of participants in a randomized, double‐blind, placebo‐controlled, phase 3 trial (SYNCHRONIZE™‐1)

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 337-346, January 2026.
Abstract Aims Survodutide, a novel glucagon receptor and glucagon‐like peptide‐1 (GLP‐1) receptor dual agonist, elicited significant weight loss in a phase 2 trial in individuals with obesity without type 2 diabetes (T2D). Two multinational phase 3 trials are investigating survodutide for obesity management in individuals with or without T2D. We report
Carel W. le Roux, Sean Wharton, Biykem Bozkurt, Elke Platz, Gabriele Bleckert, Samina Ajaz Hussain, Martina Brueckmann, Elena Startseva, Isabel M. Kloer, Lee M. Kaplan   +9 more
wiley   +1 more source

Relationship Between Helicobacter pylori Infection and Arteriosclerosis

International Journal of General Medicine, 2021
Yoshitaka Furuto, Mariko Kawamura, Jumpei Yamashita, Takahiro Yoshikawa, Akio Namikawa, Rei Isshiki, Hiroko Takahashi, Yuko Shibuya Department of Hypertension and Nephrology, NTT Medical Centre, Tokyo, JapanCorrespondence: Yoshitaka FurutoDepartment of ...
Furuto Y, Kawamura M, Yamashita J, Yoshikawa T, Namikawa A, Isshiki R, Takahashi H, Shibuya Y   +7 more
doaj  

Lobeglitazone improves glycaemic control as add‐on therapy to empagliflozin plus metformin in patients with type 2 diabetes mellitus: A double‐blind, randomised, placebo‐controlled trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 728-740, January 2026.
Abstract Aims This study aimed to evaluate the efficacy and safety of triple therapy with lobeglitazone 0.5 mg as an add‐on treatment compared with placebo in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and empagliflozin.
Da Hea Seo, Kyung Wan Min, Ho Sang Sohn, Sang Yong Kim, In‐Kyung Jeong, Cheol‐Young Park, Kun‐Ho Yoon, So Hun Kim, Bong‐Soo Cha   +8 more
wiley   +1 more source

Intracranial arteriosclerosis is not associated with cerebral amyloid deposition

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
BACKGROUND Intracranial arteriosclerosis and cerebral amyloid beta (Aβ) are both involved in the etiology of Alzheimer's disease (AD) dementia, but the direct link between these two pathologies remains elusive.
Anna M. Streiber, Julia Neitzel, Phuong Thuy Nguyen Ho, Meike W. Vernooij, Daniel Bos   +4 more
doaj   +1 more source

The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis

Cardiology Discovery
The increasing incidence of arteriosclerosis has become a significant global health burden. Arteriosclerosis is characterized by the thickening and hardening of arterial walls, which can lead to the narrowing or complete blockage of blood vessels ...
Yuesheng Zhang, Ziyin Guan, Hui Gong, Zhichao Ni, Qingzhong Xiao, Xiaogang Guo, Qingbo Xu   +6 more
doaj   +1 more source

Longitudinal Association Between the Carotid Intima‐Media Thickness and Sarcopenia in an Older Japanese Population: The SONIC Study

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT Aim Sarcopenia increases the risk of long‐term care, disease development, and mortality in older adults. It is also a risk factor for cardiovascular disease and vice versa. Using cross‐sectional and longitudinal cohort study designs, we investigated the association between the carotid intima‐media thickness (CIMT) and sarcopenia in older ...
Ken Terashima, Hiroshi Akasaka, Yuri Onishi, Taku Fujimoto, Shino Yoshida, Ryoichi Ohara, Tomohiro Minami, Yukiko Yasunobe, Masaaki Isaka, Kayo Godai, Yuya Akagi, Michiko Kido, Mai Kabayama, Saori Yasumoto, Madoka Ogawa, Takeshi Nakagawa, Yukie Masui, Takumi Hirata, Kazunori Ikebe, Yasumichi Arai, Yasuyuki Gondo, Kei Kamide, Koichi Yamamoto   +22 more
wiley   +1 more source

Causality of blood metabolites and metabolic pathways on peripheral arteriosclerosis: a Mendelian randomization study

Frontiers in Nutrition
BackgroundPeripheral arteriosclerosis is caused by any atherosclerosis outside the heart and brain. However, the underlying biological mechanisms are not fully understood.
Qian Ye, Yilin Zhou, Kai Xu, Zhili Jiang
doaj   +1 more source

Clinical Study on Masquelet Membrane Induction Technique Combined With Free Skin Grafting for the Treatment of Chronic Refractory Wounds With Bone/Tendon Exposure in Aged Patients

International Wound Journal, Volume 23, Issue 1, January 2026.
ABSTRACT The treatment of chronic wounds in the Aged is often difficult. Masquelet technique is used for the treatment of infected large segmental bone defects as it provides an adequate blood supply for bone and soft tissue reconstruction. In this study, a two‐stage wound management strategy was used, consisting of covering the initial wound with bone
Jianyuan Gao, Shenkai Su, Feiya Zhou, Yingying Zhang, Guangheng Xiang, Zupo Yu   +5 more
wiley   +1 more source

The Role of Early-Life Conditions in the Cognitive Decline due to Adverse Events Later in Life [PDF]

Cognitive functioning of elderly individuals may be affected by events such as the loss of a (grand)child or partner or the onset of a serious chronic condition, and by negative economic shocks such as job loss or the reduction of pension benefits. It is
Deeg, Dorly J. H., Lindeboom, Maarten, Portrait, France, van den Berg, Gerard J.   +3 more
core  

LTB4 Activates the MAP Kinase Pathway in Endothelial Cells to Cause Long‐Lasting Neutrophil Tethering, MCP‐1 and NO Releases

Scandinavian Journal of Immunology, Volume 103, Issue 1, January 2026.
Leukotriene B4 (LTB4), a potent leukocyte chemoattractant, links early innate and late adaptive immune responses. Here, we show that LTB4 activates endothelial cells to rapid but short‐lived as well as to later robust and prolonged tethering of neutrophils, partly via LTB4 receptors BLT1 and BLT2.
Anne‐Sofie Johansson, Jesper Z. Haeggström, Jan Palmblad   +2 more
wiley   +1 more source