Results 51 to 60 of about 65,591 (217)

Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay

Journal of Lipid Research, 2004
Acyl CoA:cholesterol acyltransferase 1 (ACAT1) and ACAT2 are enzymes responsible for the formation of cholesteryl esters in tissues. While both ACAT1 and ACAT2 are present in the liver and intestine, the cells containing either enzyme within these ...
Aaron T. Lada, Matthew Davis, Carol Kent, James Chapman, Hiroshi Tomoda, Satoshi Omura, Lawrence L. Rudel   +6 more
doaj   +1 more source

CD36 and Its Role in Obesity

Obesity Reviews, EarlyView.
ABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Nahuel Garcia, Maiken Mellergaard, Carlos Salomon, Pilar Sepulveda, Peter Kristensen, Aase Handberg   +5 more
wiley   +1 more source

Studies on the effect of dietary fish oil on the physical and chemical properties of low density lipoproteins in cynomolgus monkeys.

Journal of Lipid Research, 1991
To determine the effect of isocaloric substitution of dietary fish oil for lard on the physical and chemical properties of plasma low density lipoproteins (LDL), ten adult male cynomolgus monkeys were fed diets containing 11% (by weight) fish oil or lard
JS Parks, AK Gebre
doaj   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Understanding Arteriosclerosis 2.0: Making Sense of Genetic Variants with scATAC [PDF]

, 2021
Ralf P. Brandes, Ralf Gilsbach
openalex   +1 more source

Prognostic factors and long‐term outcomes with endoscopic submucosal dissection for colorectal tumors in patients aged 75 years or older

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Background Studies regarding the long‐term outcomes of endoscopic submucosal dissection (ESD) performed in older patients with colorectal tumors are limited. Therefore, in this study, we aimed to analyze the long‐term outcomes of older patients with colorectal tumors who underwent ESD and identify prognostic factors.
Takaya Miura, Satohiro Matsumoto, Azumi Sato, Shu Kojima, Goya Sasaki, Mina Morino, Keita Matsumoto, Hitomi Kashima, Yudai Koito, Takehiro Ishii, Shuhei Yoshikawa, Haruka Otake, Takeshi Uehara, Masanari Sekine, Takeharu Asano, Hiroyuki Miyatani, Hirosato Mashima   +16 more
wiley   +1 more source

Validation of a microRNA profile in urine liquid biopsy with diagnostic and stratification value for bladder cancer classification, available through the open app BladdermiRaCan

Experimental Hematology & Oncology
We aimed to identify a profile of urine microRNAs (miRNAs) with diagnostic and stratification potential in the whole range of bladder cancer (BC) categories, to avoid current invasive, harmful and expensive procedures.
Julia Oto, Raquel Herranz, Emma Plana, Javier Pérez-Ardavín, David Hervás, Fernando Cana, Patricia Verger, David Ramos-Soler, Manuel Martínez-Sarmiento, César D. Vera-Donoso, Pilar Medina   +10 more
doaj   +1 more source

A Novel and Simple Score to Predict Embolic or Atherosclerotic Middle Cerebral Artery Occlusion Before Mechanical Thrombectomy: AHOC Score

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This study developed and validated the novel AHOC score, a simple pre‐thrombectomy tool for predicting stroke etiology (embolism vs. intracranial atherosclerosis) in acute middle cerebral artery occlusion. This score integrates four key clinical/imaging variables—atrial fibrillation, hyperdense artery sign, stenosis/occlusion in other arteries, and ...
Hudie Zhang, Yingwen Su, Zubing Xu, Yunqing Chen, Rongwei Yang, Weiming Gan, Zhaojun Huang, Laisheng Cai, Chenying Zeng, Qin Huang, Jinchong Zhang, Keji Zou, Jingwei Huang, Pu Fang, Xiaobing Li, Yuhua Fan, Daojun Hong, Jing Lin   +17 more
wiley   +1 more source

A Case of Acquired Factor V Deficiency in a Hemodialysis Patient: A Case Report With Literature Review

IJU Case Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Acquired factor V (FV) deficiency is a rare bleeding disorder requiring careful management, especially in hemodialysis (HD) patients who regularly receive anticoagulants. We present a case of recurrent acquired FV deficiency in a dialysis patient.
Akihiko Sugino, Yoshiyuki Miyazawa, Shugo Harashima, Yusaku Shimizu, Mikiya Kajita, Yuri Miyazawa, Yoshiyuki Ogawa, Hiroshi Handa, Yoshitaka Sekine, Kazuhiro Suzuki   +9 more
wiley   +1 more source