Results 61 to 70 of about 10,785 (184)

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

Cell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi‐Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu, Gang Fan, Juan Peng, Xiaoyan Dai, Zhihan Tang   +13 more
wiley   +1 more source

Influence of dietary fatty acid composition on the relationship between CETP activity and plasma lipoproteins in monkeys

Journal of Lipid Research, 2001
CETP activity, measured as transfer of cholesteryl ester from exogenous HDL to exogenous VLDL and LDL, reflecting CETP mass as determined by ELISA, was documented in three groups of St.
Yuichi Fusegawa, Kathryn L. Kelley, Janet K. Sawyer, Ramesh N. Shah, Lawrence L. Rudel   +4 more
doaj   +1 more source

The role of phosphatidylserine recognition receptors in multiple biological functions

Cellular & Molecular Biology Letters, 2020
Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis. Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase-dependent apoptosis, which in turn promotes the expression of “eat me ...
Mehri Bemani Naeini, Vanessa Bianconi, Matteo Pirro, Amirhossein Sahebkar   +3 more
doaj   +1 more source

Doxorubicin‐induced Cardiotoxicity in Dogs: A Narrative Review

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Doxorubicin, an anthracycline widely used in both human and veterinary oncology, is highly effective against a variety of malignancies in dogs, including lymphomas, sarcomas and carcinomas. Despite its efficacy, doxorubicin exposure can be associated with cardiotoxicity, which may present acutely or chronically, potentially leading to severe ...
Supita Sunpongsri, Tom Roos, Ronette Gerhing, Maurice Zandvliet, Giorgia Santarelli   +4 more
wiley   +1 more source

Ciclo celular y arteriosclerosis inducida por la dieta [PDF]

, 2009
Ciclo celular y arteriosclerosis inducida por la ...
Andrés García, Vicente
core  

Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis.

, 1997
In cardiac transplantation, chronic rejection takes the form of an occlusive vasculopathy. The mechanism underlying this disorder remains unclear. The purpose of this study was to investigate the role nitric oxide (NO) may play in the development of ...
N Kawaharada, A Lizonova, Pham, S M, Lizonova, A, Tzeng, E, T R Billiar, Kovesdi, I, Watkins, S C, S M Pham, Shears, L L, Billiar, T R, S C Watkins, Kawaharada, N, I Kovesdi, E Tzeng, L L Shears   +15 more
core   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Comparisons of clinical and laboratory data in patients with arteriosclerosis and without renal vascular lesions.

, 2015
Note: AS: arteriosclerosis; NRVL: no renal vascular lesion; TCHO: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; SLEDAI: Systemic Lupus Erythematosus Disease Activity Index ...
Dan-dan Qin (823503), Li-hua Wu (823504), Sha-sha Han (801205), Yan Song (119387), Gang Liu (81776), Su-xia Wang (823505), Jing Huang (41604), Ming-hui Zhao (3926921), Feng Yu (273443)   +8 more
core   +1 more source

Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A

Journal of Lipid Research, 1973
A new assay for 3-hydroxy-3-methylglutaryl CoA reductase (mevalonate: NADP oxidoreductase [acylating CoA], EC 1.1.1.34) is based upon the measurement of released coenzyme A (SH) during the reduction of 3-hydroxy-3-methylglutaryl CoA to mevalonate ...
Frank H. Hulcher, Wayne H. Oleson
doaj   +1 more source