Results 81 to 90 of about 135,678 (310)

Curcumin ameliorates hyperuricemia and gout‐induced damage via modulating the ROS‐dependent NEK7‐NLRP3 inflammasome activation

Smart Molecules, EarlyView.
Curcumin inhibits the ROS/NEK7‐NLRP3 inflammasome pathway by reducing reactive oxygen species (ROS) levels and disrupting the association of the NEK7‐NLRP3 complex. These combined effects of curcumin result in suppression of the GSDMD‐N pyroptotic pore formation and subsequent reduction of IL‐1β release.
Zhengtian Zhao, Xiaowei Tong, Jing Sun, Jiaqi Lu, Guangyu Zhang, Qing Wang, Li Yang   +6 more
wiley   +1 more source

Low intensive anticoagulation ought to be regarded as a trusted concept for treatment of selected Medtronic open pivot mechanical aortic valve patients [PDF]

, 2016
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Bové, Thierry, Caes, Frank, Francois, Katrien, Taeymans, Yvo, Van Belleghem, Yves, Van Nooten, Guido   +5 more
core   +1 more source

Characteristics and toxicology of adult deaths due to quetiapine toxicity in Australia, 2000–2024

Journal of Forensic Sciences, EarlyView.
Abstract Quetiapine is an atypical antipsychotic that has been associated with both intentional and unintentional deaths. We aimed to determine, stratified by intentionality: (1) The characteristics and circumstances of adult deaths attributed solely to quetiapine toxicity in Australia, 2000–2024; (2) The blood toxicology of cases for quetiapine and ...
Shane Darke, Johan Duflou, Julia Lappin, Michael Farrell, Amy Peacock   +4 more
wiley   +1 more source

Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men

Journal of Lipid Research, 2007
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-dependent transcription factor that plays a key role in lipid and glucose homeostasis. This study evaluated whether variants of PPARα are associated with postprandial lipemia. Subjects were
Toshiko Tanaka, Jose M. Ordovas, Javier Delgado-Lista, Francisco Perez-Jimenez, Carmen Marin, Pablo Perez-Martinez, Purificacion Gomez, Jose Lopez-Miranda   +7 more
doaj  

Immune-Mediated Vascular Injury and Dysfunction in Transplant Arteriosclerosis

Frontiers in Immunology, 2015
Solid organ transplantation is the only treatment for end-stage organ failure but this life-saving procedure is limited by immune-mediated rejection of most grafts.
Anna von Rossum, I. Laher, J. Choy
semanticscholar   +1 more source

Analysis of the molecular mobility of collagen and elastin in safe, atheromatous and aneurysmal aortas [PDF]

, 2012
Aim of the study : In this study, we propose to use a thermal technique, Differential Scanning Calorimetry (DSC) to follow the evolution of elastin and collagen in safe and pathological cardiovascular tissues.
Dandurand, Jany, Degani, Annamaria, Gandaglia, Alessandro, Gargiulo, Mauro, Lacabanne, Colette, Samouillan, Valérie, Spina, Michel, Stella, Andréa   +7 more
core   +2 more sources

Impact of barometric pressure on blood pressure during dialysis: Introducing intradialytic time‐averaged cumulative systolic blood pressure (TACsBP‐inD) as a new metric

Therapeutic Apheresis and Dialysis, Volume 29, Issue 3, Page 525-534, June 2025.
Abstract Background Blood pressure is a crucial risk factor for hemodialysis patients, but the specific impact of weather factors, particularly barometric pressure, on blood pressure remains unclear. This study aims to examine the relationship between barometric pressure and blood pressure in hemodialysis patients. Methods We conducted a single‐center,
Kosaku Iwatsubo, Shouichi Fujimoto, Michikazu Nakai   +2 more
wiley   +1 more source

ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice

Journal of Lipid Research, 2005
The relative contributions of ACAT2 and LCAT to the cholesteryl ester (CE) content of VLDL and LDL were measured. ACAT2 deficiency led to a significant decrease in the percentage of CE (37.2 ± 2.1% vs.
Richard G. Lee, Ramesh Shah, Janet K. Sawyer, Robert L. Hamilton, John S. Parks, Lawrence L. Rudel   +5 more
doaj  

Linking Induction and Transrepression of PPARβ/δ with Cellular Function [PDF]

, 2015
The copyrights of all papers published in this journal are retained by the respective authors as per the 'Creative Commons Attribution License' (http://creativecommons.org/licenses/by/3.0/).Peroxisome proliferator activated receptors (PPARs) are ligand ...
MacKenzie, Louise Susan, Perez Diaz, Noelia   +1 more
core   +3 more sources

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source