Results 31 to 40 of about 62,867,233 (175)

La determinación temporal del enunciado (VI): El subsistema 4 [PDF]

open access: yes, 2008
El subsistema 4 corresponde a los determinadores que poseen las marcas generales: temporal (en sentido estricto), no comparativo, no modal, no durativo, sin determinación de repetición e implica frecuencia de los eventos.
Loma-Osorio Fontecha, Marciana   +2 more
core   +1 more source

Headache in the elderly: a series of 262 patients

open access: yesNeurología (English Edition), 2014
Introduction: Although headache prevalence decreases in patients older than 65, headaches are a common complaint and their different clinical and therapeutic features must be understood.
M. Ruiz   +9 more
doaj   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

open access: yesAdvanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert   +8 more
wiley   +1 more source

Cefaleas en la persona mayor: características de una serie de 262 pacientes

open access: yesNeurología, 2014
Resumen: Introducción: Aunque la prevalencia de las cefaleas disminuye en las personas mayores (≥ 65 años), son causa importante de consulta, con particularidades diagnósticas y terapéuticas que es necesario conocer.
M. Ruiz   +9 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

open access: yesAdvanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang   +12 more
wiley   +1 more source

Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez   +295 more
wiley   +1 more source

Human Monocytic Models Reveal Genotype‐Dependent Inflammatory Programs in VEXAS Syndrome

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives VEXAS syndrome is a severe X‐linked autoinflammatory disorder caused by somatic mutations in ubiquitin‐like modifier activating enzyme 1 (UBA1), with clinical outcomes that vary by UBA1 genotype. We aimed to elucidate genotype‐specific inflammatory programs and identify potential therapeutic targets.
Kana Higashitani   +10 more
wiley   +1 more source

Incidence and disease course of polymyalgia rheumatica during two decades: a nationwide study across healthcare sectors in Denmark

open access: yesArthritis &Rheumatology, Accepted Article.
Objective A new algorithm enables the identification of patients with polymyalgia rheumatica (PMR) across healthcare sectors in Denmark. We estimated annual incidence rates from 2003 to 2024 and described the disease course, including the occurrence of late‐onset GCA and prednisolone (PDN) treatment. Methods A Danish nationwide, population‐based cohort
Agnete O Donskov   +4 more
wiley   +1 more source

Arteritis de takayasu presentación de una caso clínico y revisión de la literatura

open access: yes, 2022
Takayasu arteritis is classified as a large-vessel vasculitis because it primarily affects the aorta and its primary branches. It also shares some histologic and clinical features with giant cell (temporal) arteritis, the other major large-vessel ...
Duarte Montiel, Erica Danahe   +1 more
core   +1 more source

Shared and Distinguishing Features of Late‐Onset Rheumatic Diseases Fulfilling Polymyalgia Rheumatica Classification Criteria

open access: yesArthritis &Rheumatology, Accepted Article.
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Kerem Abacar   +5 more
wiley   +1 more source

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