Results 141 to 150 of about 97,243 (208)

Type 1 Diabetes and Other Autoimmune Diseases—Epidemiology, Pathophysiology and Screening

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Individuals with type 1 diabetes exhibit significantly increased prevalence of additional autoimmune diseases. Epidemiological, familial and mechanistic evidence indicates frequent polyautoimmunity and shared genetic and environmental drivers. Coexistence complicates clinical management, and autoantibody‐based detection often identifies preclinical ...
George J. Kahaly, Thomas Forst, Monika Kellerer, Stefanie Lanzinger, René D. Rötzer, Matthias Schott, Petra‐Maria Schumm‐Draeger   +6 more
wiley   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, Volume 46, Issue 1, Page 149-175, January 2026.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

Comparative evaluation of supervised and unsupervised deep learning strategies for denoising hyperpolarized 129Xe lung MRI

Magnetic Resonance in Medicine, Volume 95, Issue 1, Page 138-156, January 2026.
Abstract Purpose Reduced signal‐to‐noise ratio (SNR) in hyperpolarized 129Xe MR images can affect accurate quantification for research and diagnostic evaluations. Thus, this study explores the application of supervised deep learning (DL) denoising, traditional (Trad) and Noise2Noise (N2N) and unsupervised Noise2void (N2V) approaches for 129Xe MR ...
Abdullah S. Bdaiwi, Matthew M. Willmering, Riaz Hussain, Erik Hysinger, Jason C. Woods, Laura L. Walkup, Zackary I. Cleveland   +6 more
wiley   +1 more source

Weight‐reducing treatments are associated with an improvement in depression, functional health status, and quality of life: A meta‐analysis of randomized controlled trials

Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 347-357, January 2026.
Abstract Aim To assess whether there is a beneficial or detrimental effect of weight reduction on mental health. Materials and methods Meta‐analysis of randomized trials performed for weight loss, in which weight loss at endpoint was greater than 5% in the intervention arm and smaller than 5% in the control arm, obtained with any surgical, endoscopic ...
Giovanni Antonio Silverii, Matteo Monami, Francesco Rotella, Maurizio De Luca, Tommaso Viozzi, Rocco Barazzoni, Silvio Buscemi, Luca Busetto, Paolo Sbraccia, Edoardo Mannucci   +9 more
wiley   +1 more source

Physical activity and quality of life of children and adolescents with juvenile idiopathic arthritis, juvenile systemic lupus erythematosus and juvenile dermatomyositis during the COVID-19 pandemic. [PDF]

J Pediatr (Rio J)
Soares R, Silva FC, Fernandez JD, Fraga MM, Terreri MT, Len CA.   +5 more
europepmc   +1 more source

Importance and Potential of Rare Disease Research in Pediatric Rheumatology and Beyond: Pushing Frontiers

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Although individually occurring in less than 1 in 2,000 people, cumulatively, more than 7,000 rare diseases affect approximately 6% of the population worldwide. Children and young people are disproportionally challenged in number and severity, which may be explained by the large proportion of genetic conditions among rare diseases (70%–80%). Indeed, an
Christian M. Hedrich
wiley   +1 more source

Advancing Juvenile Spondyloarthritis: Closing Knowledge Gaps with New Axial JSpA Classification Criteria. [PDF]

Curr Rheumatol Rep
Newby BN, Weiss PF.
europepmc   +1 more source

Fish Pathogens and Associated Zoonotic Risks in Aquaculture: A Global One Health Perspective

Aquaculture, Fish and Fisheries, Volume 5, Issue 6, December 2025.
ABSTRACT Aquaculture sector is a key contributor to global food and nutritional security, yet its rapid intensification has heightened concerns about the emergence and spread of zoonotic fish pathogens that threaten human, animal and environmental health.
Fredrick Juma Syanya, Sajna Beegum, Zachariy Oreko Winam, Fazeena Fariq, A. R. Nikhila Khanna, Megha Lovejan, Mujeeb Rahiman K. M., Harikrishnan Mahadevan   +7 more
wiley   +1 more source

Further Evidence That Chondrocalcinosis 1 (CCAL1) is a Confirmed Mendelian Phenotype With a Known Molecular Basis

American Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.
ABSTRACT Chondrocalcinosis (CCAL), also known as calcium pyrophosphate dihydrate deposition disease (CPPDD), is a frequent multifactorial condition in the elderly, but there are two rare autosomal dominant Mendelian forms, CCAL1 (OMIM %600668) and CCAL2. Only three families with molecularly proven CCAL1 have been reported.
Anna‐Christina Pansa, Mareike Selig, Markus Wingendorf, Matthew A. Brown, Oliver Bartsch   +4 more
wiley   +1 more source

Ethnic Differences in Juvenile Idiopathic Arthritis in the Circumpolar Region. [PDF]

Children (Basel)
Boeskorova SG, Afonskaya MV, Argunova VM, Sleptsova PA, Leonteva LV, Nikiforova VV, Chikova IA, Yakovlev AA, Burtseva TE, Kostik MM.   +9 more
europepmc   +1 more source