Results 61 to 70 of about 54,430 (257)

Systemic juvenile idiopathic arthritis complicated by hemophagocytic syndrome

Клинический разбор в общей медицине
Systemic juvenile idiopathic arthritis is a polygenic autoinflammatory disease. Pronounced systemic clinical manifestations, a significant increase in the level of inflammatory markers and the absence of autoantibodies distinguish this disease from other
Natalya A. Belykh, Ksenia V. Sinitsyna, Yuliya V. Deeva, Inna V. Piznyur, Alla Yu. Lashko   +4 more
doaj   +1 more source

Discrimination of acute lymphoblastic leukemia from systemic-onset juvenile idiopathic arthritis at disease onset

Clinics, 2011
OBJECTIVE: To assess clinical and laboratory features that differentiate acute lymphoblastic leukemia from systemic juvenile idiopathic arthritis at disease onset. METHODS: Fifty-seven leukemia patients with musculoskeletal involvement, without blasts on
Mirian S. Tamashiro, Nadia Emi Aikawa, Lucia Maria A. Campos, Lilian Maria Cristofani, Vicente Odone-Filho, Clovis A. Silva   +5 more
doaj   +1 more source

Facilitating Expedited Drug Approval—the Past, Present, and Future of Clinical Trials for Pediatric Rheumatic Disease

Arthritis Care &Research, EarlyView.
Pamela F. Weiss, Hermine I. Brunner
wiley   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Current Validated Clinical and Patient Reported Disease Outcome Measures in Juvenile Idiopathic Arthritis

Open Access Rheumatology: Research and Reviews, 2023
Erin Balay-Dustrude,1,2 Susan Shenoi1,2 1Department of Pediatrics, Division of Rheumatology, University of Washington, Seattle, WA, USA; 2Department of Pediatric Rheumatology, Seattle Children’s Hospital and Research Center, Seattle, WA ...
Balay-Dustrude E, Shenoi S
doaj  

Clinical characteristics and genotype analysis of a Chinese patient with juvenile arthritis due to novel LACC1 frameshift mutation and literature review

Molecular Genetics & Genomic Medicine, 2023
Background Some juvenile idiopathic arthritis (JIA) patients have a familial aggregation of the disease, and a few have been found to have a juvenile arthritis (JA) phenotype caused by a genetic mutation.
Yali Wu, Shasha Wang, Wen Yin, Wei Yin, Yan Ding   +4 more
doaj   +1 more source

EFFICACY OF ETANERCEPT IN TREATMENT OF VARIOUS TYPES OF JUVENILE IDIOPATHIC ARTHRITIS

Вопросы современной педиатрии, 2013
Aim: to assess efficacy and safety of etanercept in treatment of various types of juvenile idiopathic arthritis in children under conditions of real clinical practice.
O. Yu. Konopel'ko, E. S. Zholobova, M. N. Nikolaeva, O. S. Rozvadovskaya, V. Ya. El'yashevich, E. Yu. Afonina   +5 more
doaj   +1 more source

Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double‐Blind, Proof‐of‐Concept Study

Arthritis &Rheumatology, EarlyView.
Objective To assess guselkumab + golimumab combination therapy versus guselkumab monotherapy in participants with active psoriatic arthritis (PsA) and inadequate response to tumor necrosis factor inhibitors (TNFi‐IR). Methods Adults with active TNFi‐IR PsA (three or more tender/swollen joints) were randomized (2:1) to subcutaneous guselkumab (100 mg) +
Jose U. Scher, Iain B. McInnes, Enrique R. Soriano, Joseph F. Merola, Paul Bird, Vinod Chandran, Edaire Cheng, Elena Reynoso, Warner Chen, Maoji Li, Lianne S. Gensler, Philip J. Mease, Christopher T. Ritchlin   +12 more
wiley   +1 more source

Defining criteria for disease activity states in systemic juvenile idiopathic arthritis based on the systemic Juvenile Arthritis Disease Activity Score [PDF]

Objective To develop and validate cutoff values in the systemic Juvenile Arthritis Disease Activity Score 10 (sJADAS10) that distinguish the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high ...
Robasto, Francesca, Silva, Rodrigo M., Shalaby, Radwa H., Consolaro, A., Marrani, Edoardo, Villarreal, Giselle, Lotfy, Hala M., Ozen, S., Costi, Stefania, Kriulin, Ivan, Sztajnbok, Flavio, Al‐Mayouf, Sulaiman M., Abu-Zaid, M., Abu‐Rumeleih, S., Hassan, Waleed, Maggio, Maria C., Minoia, F., Civino, Adele, Montin, Davide, Tarantola, Letizia, Khubchandani, Raju, Fouad, Nermeen A., Osman, Naglaa S., Vilaiyuk, Soamarat, Filocamo, Giovanni, Pal, P., Maldar, Naziya P., Almaaitah, Hiba, Al‐Sofyani, Fuad, Bracaglia, C., El Owaidy, R., El Miedany, Yasser, Alzyoud, Raed, Pardeo, M., Khan, A., Mahgoub, Marwa Y., Patrone, Elisa, Bathia, Jigna N., Saad‐Magalhães, Claudia, Eissa, M., Lerkvaleekul, Butsabong, Simonini, Gabriele, De Benedetti, F., Katsicas, María M., Ravelli, A., Rebollo‐Gimenez, Ana I., Mosa, D., Bayindir, Yagmur, Licciardi, F., Abu‐Shady, Hend, Vyzhga, Y., Radwan, Ahmed R., Alexeeva, Ekaterina, Dvoryakovskaya, Tatyana, Marino, Achille, Nasef, S., Kostik, M., Dāvidsone, Zane, Pistorio, Angela, Adel, Yasmin, Diomeda, Federico, Alsuweiti, Motasem, Rosina, Silvia, Tabra, Samar A. A., Rossano, Martina, El‐Ghoneimy, Dalia H., Mohamed, Sheren E. M., Belozerov, Konstantin E.   +67 more
core   +1 more source