Results 121 to 130 of about 1,088,180 (293)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

A Monolithic Janus Hydrogel Pressure Sensor for Wearable Motion and Physiological Monitoring

Advanced Science, EarlyView.
This work reports a monolithic Janus hydrogel pressure sensor featuring integrated conductive PEDOT and insulating PEGDA layers. The fabricated device achieves a rapid response time, a wide operating range, and good cyclic durability. The sensor demonstrates robust performance in tracking dynamic human joint motions, offering a scalable strategy for ...
Syed Atif Ali, Zeeshan Alam Ansari, Reynaldo Carlos Kuizon Montalbo, Hailemichael Ayalew, Yu‐Sheng Hsiao, Chih‐Wei Chu, Hsiao‐hua Yu, Hsiung‐Lin Tu   +7 more
wiley   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

A young man with oligoarthritis preceded by urethritis and diarrhea

Southwest Respiratory and Critical Care Chronicles, 2014
Reactive arthritis is a form of seronegative spondyloarthritis temporally triggered by an apparent infection, usually gastroenteritis or urethritis. This arthritis typically starts within a few weeks of the inciting infection.
Ahmed Zedan, Imran Umer, Yasir Ahmed, Donald Loveman   +3 more
doaj  

Successful Treatment of Post‐SARS‐CoV‐2 Infection Reactive Arthritis With Secukinumab: A Case Report and Literature Review

Clinical Case Reports
This case describes a rare occurrence of post‐SARS‐CoV‐2 infection reactive arthritis with psoriasiform lesions. The patient failed to respond to conventional therapies but responded well to secukinumab, underscoring that it may be a valuable treatment ...
Qi Zhao, Tianyu Yao, Danyue He, Jie Hu, Yulin Wang, Ruyi Wang, Yiyang Hu, Chengyu Li, Jia Cai, Xiangning Li, Lili Tang, Xing Fan   +11 more
doaj   +1 more source

Electrochemically Driven Regioselective Radical Functionalization of Allenes: Scope and Mechanistic Insights

Advanced Science, EarlyView.
Allenes emerge as powerful platforms for electrochemical functionalization through radical pathways. Selective radical addition at the central carbon triggers anodic oxidation and intramolecular cyclization, enabling efficient synthesis of oxazolines and oxazolidine‐2‐imines without external oxidants.
Pranjal Pyne, Prateek Saini, Rohel Hoque, Shivam Pandey, Srinivasan Ramakrishnan, Chandra M. R. Volla   +5 more
wiley   +1 more source

Reactive Arthritis Triggered by Adalimumab and Leflunomide in a Patient with Ankylosing Spondylitis

, 2022
Ying Liu, Jia He, Jingjing Jiang, Yujuan Wang, Ting Liu Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of ChinaCorrespondence: Ting Liu, Department of Dermatology, Affiliated Hospital of North
Liu Y, Jiang J, He J, Wang Y, Liu T
core  

Reactive arthritis

Indian Journal of Rheumatology, 2008
R Misra
doaj   +1 more source

C - reactive protein predicts proximal femur osteomyelitis in suppurative hip arthritis

Journal of Orthopaedic Surgery and Research
Background Ultrasound is capable of detecting hip joint effusion and guiding puncture procedures, which is cheap and convenient, but can not identify osteomyelitis.
Haiting Jia, Tao Liu, Jiazhi Yu, Mingzhu Lu   +3 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source