Results 1 to 10 of about 1,728 (183)
Targeting Prohibitins to Inhibit Melanoma Growth and Overcome Resistance to Targeted Therapies [PDF]
Cells, 2023 Despite important advances in the treatment of metastatic melanoma with the development of MAPK-targeted agents and immune checkpoint inhibitors, the majority of patients either do not respond to therapies or develop acquired resistance.
Ahmad Najem +2 more
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Current Biology, 2017 Tatsuta and Langer introduce prohibitins, membrane scaffolding proteins found predominantly in mitochondria.
Takashi Tatsuta, Thomas Langer
exaly +6 more sources
Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases [PDF]
Cells, 2019 Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed, and are present in the nucleus, cytosol, and mitochondria.
Anna Signorile +2 more
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Prohibitins in infection: potential therapeutic targets [PDF]
Future MicrobiologyProhibitins (PHBs) are members of a highly conserved family of proteins, including prohibitin1 and prohibitin2. These proteins are predominantly localized in mitochondria, the nucleus, and cell membranes, where they play critical roles in mitochondrial biogenesis, apoptosis, immune regulation, and other biological processes.
Chen, Nuo +11 more
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Prohibitins in neurodegeneration and mitochondrial homeostasis
Frontiers in Aging, 2022 The incidence of age-related neurodegenerative disorders has risen with the increase of life expectancy. Unfortunately, the diagnosis of such disorders is in most cases only possible when the neurodegeneration status is already advanced, and symptoms are
Jesus Fernandez-Abascal +3 more
doaj +5 more sources
The emerging roles of prohibitins in folliculogenesis [PDF]
Frontiers in Bioscience - Elite, 2012 Prohibitins are members of a highly conserved eukaryotic protein family containing the stomatin/prohibitin/flotillin/HflK/C (SPFH) domain (also known as the prohibitin (PHB) domain) found in divergent species from prokaryotes to eukaryotes. Prohibitins are found in unicellular eukaryotes, fungi, plants, animals and humans.
Winston E Thompson +2 more
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Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer [PDF]
Cells, 2023 Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi +5 more
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The function of prohibitins in mitochondria and the clinical potentials
Cancer Cell International, 2022 Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways.
Linda Oyang +14 more
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The Prohibitins: emerging roles in diverse functions [PDF]
Journal of Cellular and Molecular Medicine, 2006 The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name prohibitin.
Suresh Mishra, Leigh C Murphy
exaly +3 more sources
Antioxidants, 2023 Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under cardiac stress remains poorly understood.
Kaina Zhang +6 more
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