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Structural and Biophysical Characterization of Prohibitin
, 2016 Prohibitin (PHB) is a multimeric protein found on lipid rafts of the eukaryotic inner-mitochondrial membrane. The protein is comprised of 3 domains: an N-terminal transmembrane helix, a PHB domain found at the center, and followed by a C-terminal coiled-coil domain.
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Prohibitin and the senescent phenotype
Experimental Gerontology, 1996Prohibitin is an evolutionarily conserved gene that has antiproliferative activity, is ubiquitously expressed, and appears to be essential for cell survival. The gene codes for a 30 kD, post-synthetically modified protein located primarily in the mitochondria.
R T, Dell'Orco +3 more
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Prohibitin 2: At a communications crossroads
IUBMB Life, 2015AbstractProhibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators
Bavelloni A +4 more
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Molecular modeling of prohibitin domains
Proteins: Structure, Function, and Bioinformatics, 2007AbstractProhibitins comprise a family of highly conserved ubiquitous eukaryotic proteins that mainly localize to the mitochondria. They have been implicated in important cellular processes such as cellular signaling and transcriptional control, apoptosis, cellular senescence, and mitochondrial biogenesis.
Winter, Anja +2 more
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Prohibitin in Adipose and Immune Functions
Trends in Endocrinology & Metabolism, 2016Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence.
Sudharsana R, Ande +3 more
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Identification of prohibitin as an antigen in Behcet’s disease
Biochemical and Biophysical Research Communications, 2014This study is intended to screen potential antigen for Behcet's disease (BD) by using human microvascular endothelial cells (HUVEC).Following cell-based indirect immunofluorescence assay with sera from BD patients, proteins extracted from HUVEC were separated and detected by Western blotting.
Yiping, Xun +6 more
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Prohibitin plays a role in the functional plasticity of macrophages
Molecular Immunology, 2022Immunometabolism plays a crucial role in the activation and functional plasticity of immune cells, which in large determines a variety of health and disease states. Factors that integrate immunometabolism in immune cell signaling and functions are beginning to be identified.
Yang Xin Zi, Xu +5 more
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Prohibitin: a potential target for new therapeutics
Trends in Molecular Medicine, 2005Prohibitin (PHB) is localized to the mitochondria where it might have a role in the maintenance of mitochondrial function and protection against senescence. There is considerable controversy concerning the function of nuclear-localized PHB. PHB has potential roles as a tumor suppressor, an anti-proliferative protein, a regulator of cell-cycle ...
Suresh, Mishra +3 more
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