Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors [PDF]
npj VirusesJapanese encephalitis virus (JEV), an Orthoflavivirus transmitted by mosquitoes, can cause severe disease in humans, yet its interactions with mosquito vectors remain poorly understood.
Mazhar Hussain +5 more
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Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance [PDF]
Microbiology SpectrumThe SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast Candida albicans, stomatin-
Hyunjeong Kim +7 more
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Prohibitins: emerging host targets of bacteria and viruses at the plasma membrane, mitochondria, and cytoplasm [PDF]
Microbial CellUbiquitously expressed Prohibitin-1 (PHB1) and Prohibitin-2 (PHB2) serve pleiotropic functions in cellular processes, including signal transduction, mitochondrial metabolism and dynamics, and lipid raft formation. Located in phospholipid-rich subcellular
Grecia O. Rivera-Palomino +1 more
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Plasmodium falciparum stomatin-like protein forms a putative complex with a metalloprotease in distinct mitochondrial loci. [PDF]
PLoS PathogensMembers of the Stomatin, Prohibitin, Flotillin and HflK/C (SPFH) protein family form large membrane anchored or spanning complexes and are involved in various functions in different organelles.
Julie M J Verhoef +7 more
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Structures of human organellar SPFH protein complexes [PDF]
Nature CommunicationsStomatin, Prohibitin, Flotillin, and HflK/C (SPFH) family proteins are found in all kingdoms of life and in multiple eukaryotic organelles. SPFH proteins assemble into homo- or hetero-oligomeric rings that form domed structures. Most SPFH assemblies also
Jingjing Gao +5 more
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OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase
Cell ReportsSummary: Mitochondrial proteins are transported and sorted to the matrix or inner mitochondrial membrane by the presequence translocase TIM23. In yeast, this essential and highly conserved machinery is composed of the core subunits Tim23 and Tim17.
Praveenraj Elancheliyan +10 more
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Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. [PDF]
PLoS ONE, 2013 Prohibitin is an evolutionary conserved and pleiotropic protein that has been implicated in various cellular functions, including proliferation, tumour suppression, apoptosis, transcription, and mitochondrial protein folding.
Tian-Biao Zhou +4 more
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Dihydromyricetin induces mitophagy by regulating Prohibitin 2 pathway in vascular endothelial cells
Di-san junyi daxue xuebao, 2022 Objective To observe the effects of dihydromyricetin on mitophagy in vascular endothelial cells, and to clarify the underlying role of Prohibitin 2 in the process.
HU Qin, SHEN Hui, ZHANG Ting, LI Yafei
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Triazine-Based Small Molecules: A Potential New Class of Compounds in the Antifungal Toolbox
Pathogens, 2023 Invasive fungal infections caused by Candida species remain a significant public health problem worldwide. The increasing prevalence of drug-resistant infections and a limited arsenal of antifungal drugs underscore the need for novel interventions. Here,
Karen A. Conrad +6 more
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Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans. [PDF]
PLoS ONE, 2014 Lifespan regulation by mitochondrial proteins has been well described, however, the mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins profoundly affecting ageing are prohibitins (PHB-1 and PHB-2).
Roxani Gatsi +5 more
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