Results 31 to 40 of about 7,558 (163)
Mediators of Inflammation, 2013 Prohibitin, which can inhibit oxidative stress and mitochondrial dysfunction, has been shown to have significant anti-inflammatory activities. Here, we investigate the effects of altering prohibitin levels in affected tissues in the interleukin-10 ...
C. Yuan +6 more
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A Conserved Mitochondrial Chaperone-Protease Complex Involved in Protein Homeostasis
Frontiers in Molecular Biosciences, 2021 Mitochondria are essential organelles involved in cellular energy production. The inner mitochondrial membrane protein stomatin-like protein 2 (SLP-2) is a member of the SPFH (stomatin, prohibitin, flotilin, and HflK/C) superfamily and binds to the ...
Mauro Serricchio, Peter Bütikofer
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Microorganisms, 2021 Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms.
Marienela Y. Heredia, Jason M. Rauceo
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Prohibitin Links Cell Cycle, Motility and Invasion in Prostate Cancer Cells [PDF]
, 2023 Prohibitin (PHB) is a tumour suppressor gene with several different molecular activities. PHB overexpression leads to G1/S-phase cell cycle arrest, and PHB represses the androgen receptor (AR) in prostate cancer cells.
Jiang, W.G. +3 more
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Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination
Frontiers in Cellular Neuroscience, 2017 Hippocampal neurogenesis persists throughout adult life and plays an important role in learning and memory. Although the influence of physical exercise on neurogenesis has been intensively studied, there is controversy in regard to how the impact of ...
Ji H. So +10 more
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Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
Frontiers in Genetics, 2021 A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins
Misa Belser +2 more
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Opposing function of mitochondrial prohibitin in aging [PDF]
, 2016 This is an open‐access article distributed under the terms of the Creative Commons Attribution License.While specific signalling cascades involved in aging, such as the insulin/IGF‐1 pathway, are well‐described, the actual metabolic changes they elicit ...
Artal-Sanz, Marta +1 more
core +1 more source
Prohibitin participates in the HIRA complex to promote cell metastasis in breast cancer cell lines
FEBS Open Bio, 2020 Prohibitin (PHB) is a highly conserved, ubiquitously expressed, multifunctional protein with a well‐characterized function as a chaperone‐stabilizing mitochondrial proteins.
Xiaoqing Huang, Jinji Liu, Qinghui Ma
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Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer
Cells, 2023 Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi +5 more
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Advanced Science, 2022 Persistent uptake of high‐calorie diets induces the storage of excessive lipid in visceral adipose tissue. Lipids secreted from obese adipose tissue are accumulated in peripheral tissues such as the liver, pancreas, and muscle, and impair insulin ...
Juhyeong Hong, Yong‐Hee Kim
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