Results 31 to 40 of about 7,232 (211)
Prohibitin Links Cell Cycle, Motility and Invasion in Prostate Cancer Cells [PDF]
, 2023 Prohibitin (PHB) is a tumour suppressor gene with several different molecular activities. PHB overexpression leads to G1/S-phase cell cycle arrest, and PHB represses the androgen receptor (AR) in prostate cancer cells.
Jiang, W.G. +3 more
core +1 more source
Ras-Raf Signaling Needs Prohibitin [PDF]
Cell Cycle, 2005 Prohibitin has been connected to diverse cellular functions including cell cycle control, senescence, apoptosis and stabilization of mitochondrial proteins. By employing a loss of function approach using siRNAs we have demonstrated an unexpected role of PHB in the activation of Raf/MEK/ERK pathway by active Ras and in modulating epithelial cell ...
Rajalingam, K., Rudel, T.
openaire +3 more sources
Prohibitins are required for cancer cell proliferation and adhesion.
PLoS ONE, 2010 Prohibitin 1 (PHB1) is a highly conserved protein that together with its homologue prohibitin 2 (PHB2) mainly localizes to the inner mitochondrial membrane.
Claudia Sievers +3 more
doaj +1 more source
eLife, 2021 Dysfunction of the mitochondrial electron transport chain (mETC) is a major cause of human mitochondrial diseases. To identify determinants of mETC function, we screened a genome-wide human CRISPRi library under oxidative metabolic conditions with ...
Maxence Le Vasseur +10 more
doaj +1 more source
Virology Journal, 2011 Background Currently, up-regulated proteins and apoptosis in hepatitis C is a hot topic in exploring the pathogenic mechanism of Heptitis C Virus(HCV). Some recent studies shows that prohibitin is overexpressed in cells expressing HCV core proteins, and ...
Wang Wen-Jun +7 more
doaj +1 more source
A Conserved Mitochondrial Chaperone-Protease Complex Involved in Protein Homeostasis
Frontiers in Molecular Biosciences, 2021 Mitochondria are essential organelles involved in cellular energy production. The inner mitochondrial membrane protein stomatin-like protein 2 (SLP-2) is a member of the SPFH (stomatin, prohibitin, flotilin, and HflK/C) superfamily and binds to the ...
Mauro Serricchio, Peter Bütikofer
doaj +1 more source
Involvement of prohibitin 1 and prohibitin 2 upregulation in cBSA-induced podocyte cytotoxicity
Journal of Food and Drug Analysis, 2020 Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, when not effectively treated. The aim of this study was to discover new targets for the diagnosis and treatment of MN. A reliable mouse model of MN was used by the administration of cationic bovine serum albumin (cBSA).
Heng-Hsiung Wu +3 more
openaire +2 more sources
Development of prohibitin ligands against osteoporosis
European Journal of Medicinal Chemistry, 2021 Current therapeutic approaches to osteoporosis display some potential adverse effects and a limited efficacy on non-vertebral fracture reduction. Some sulfonylamidines targeting the scaffold proteins prohibitins-1 and 2 (PHB1/2) have been showed to inhibit the formation of osteoclasts in charge of bone resorption. Herein, we report the development of a
Redouane Tabti +6 more
openaire +4 more sources
International Journal of COPD, 2022 Yating Peng,1– 3 Wei Cheng,1– 3 Jiaxi Duan,1– 3 Yiyang Zhao,1– 3 Zijing Zhou,1– 3 Aiyuan Zhou,1– 3 Minhua Deng,1– 4 Hong Peng,1– 3 Ruoyun Ouyang,1– 3 Yan Chen,1– 3 Ping Chen1– 3 1Department of Pulmonary and Critical Care Medicine, Second Xiang Ya ...
Peng Y +10 more
doaj
Microorganisms, 2021 Integral membrane proteins from the ancient SPFH (stomatin, prohibitin, flotillin, HflK/HflC) protein superfamily are found in nearly all living organisms.
Marienela Y. Heredia, Jason M. Rauceo
doaj +1 more source