Results 21 to 30 of about 6,151 (175)
Plasmodium falciparum stomatin-like protein forms a putative complex with a metalloprotease in distinct mitochondrial loci. [PDF]
PLoS PathogensMembers of the Stomatin, Prohibitin, Flotillin and HflK/C (SPFH) protein family form large membrane anchored or spanning complexes and are involved in various functions in different organelles.
Julie M J Verhoef +7 more
doaj +2 more sources
OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase
Cell ReportsSummary: Mitochondrial proteins are transported and sorted to the matrix or inner mitochondrial membrane by the presequence translocase TIM23. In yeast, this essential and highly conserved machinery is composed of the core subunits Tim23 and Tim17.
Praveenraj Elancheliyan +10 more
doaj +2 more sources
Structures of human organellar SPFH protein complexes [PDF]
Nature CommunicationsStomatin, Prohibitin, Flotillin, and HflK/C (SPFH) family proteins are found in all kingdoms of life and in multiple eukaryotic organelles. SPFH proteins assemble into homo- or hetero-oligomeric rings that form domed structures. Most SPFH assemblies also
Jingjing Gao +5 more
doaj +2 more sources
Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease. [PDF]
PLoS ONE, 2013 Prohibitin is an evolutionary conserved and pleiotropic protein that has been implicated in various cellular functions, including proliferation, tumour suppression, apoptosis, transcription, and mitochondrial protein folding.
Tian-Biao Zhou +4 more
doaj +1 more source
Current Biology, 2017 Tatsuta and Langer introduce prohibitins, membrane scaffolding proteins found predominantly in mitochondria.
Tatsuta, T., Langer, T.
openaire +3 more sources
The Role of Prohibitin-2 in Diseases
Frontiers in Bioscience-Landmark, 2023 Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis. Recently, there has been growing interest in the biological function of PHB2.
Fang Liu +3 more
openaire +3 more sources
Dihydromyricetin induces mitophagy by regulating Prohibitin 2 pathway in vascular endothelial cells
Di-san junyi daxue xuebao, 2022 Objective To observe the effects of dihydromyricetin on mitophagy in vascular endothelial cells, and to clarify the underlying role of Prohibitin 2 in the process.
HU Qin, SHEN Hui, ZHANG Ting, LI Yafei
doaj +1 more source
Prohibitin and mitochondrial biology [PDF]
Trends in Endocrinology & Metabolism, 2009 Prohibitins are ubiquitous, evolutionarily conserved proteins that are mainly localized in mitochondria. The mitochondrial prohibitin complex comprises two subunits, PHB1 and PHB2. These two proteins assemble into a ring-like macromolecular structure at the inner mitochondrial membrane and are implicated in diverse cellular processes: from ...
Artal-Sanz, Marta +1 more
openaire +3 more sources
The emerging roles of prohibitins in folliculogenesis [PDF]
Frontiers in Bioscience, 2012 Prohibitins are members of a highly conserved eukaryotic protein family containing the stomatin/prohibitin/flotillin/HflK/C (SPFH) domain (also known as the prohibitin (PHB) domain) found in divergent species from prokaryotes to eukaryotes. Prohibitins are found in unicellular eukaryotes, fungi, plants, animals and humans.
Indrajit, Chowdhury +5 more
openaire +3 more sources
Triazine-Based Small Molecules: A Potential New Class of Compounds in the Antifungal Toolbox
Pathogens, 2023 Invasive fungal infections caused by Candida species remain a significant public health problem worldwide. The increasing prevalence of drug-resistant infections and a limited arsenal of antifungal drugs underscore the need for novel interventions. Here,
Karen A. Conrad +6 more
doaj +1 more source