Results 41 to 50 of about 7,558 (163)

Prohibitin Proteine: Chaperone der Mitochondrien und Adhäsion

, 2007
Title and Table of contents 1.1. Abstract 7 1.2. Zusammenfassung 8 2\. Introduction 9 3\. Objectives 25 4\. Results 26 5\. Discussion 49 6\. Materials 58 7\. Methods 69 7.1. Cell culture methods 69 7.2. Protein methods 78
Sievers, Claudia
core   +1 more source

Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids

Frontiers in Immunology
Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Remco Kersten, David C. Trampert, Lowiek M. Hubers, Dagmar Tolenaars, Harmjan R. Vos, Stan F. J. van de Graaf, Ulrich Beuers   +6 more
doaj   +1 more source

Peptide Adjuvant to Invigorate Cytolytic Activity of NK Cells in an Obese Mouse Cancer Model

Pharmaceutics, 2021
Cancer patients who are overweight compared to those with normal body weight have obesity-associated alterations of natural killer (NK) cells, characterized by poor cytotoxicity, slow proliferation, and inadequate anti-cancer activity.
Seungmin Han, Minjin Jung, Angela S. Kim, Daniel Y. Lee, Byung-Hyun Cha, Charles W. Putnam, Kwang Suk Lim, David A. Bull, Young-Wook Won   +8 more
doaj   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

The sorting nexin Snx21 promotes flotillin‐mediated endocytosis

The FEBS Journal, EarlyView.
In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs, Enikő Lakatos, Dalma Feil‐Börcsök, Gábor Juhász, Regina Mező, Asha Kiran Maddali, András Blastyák, Aladár Pettkó‐Szandtner, Hajnalka Laczkó‐Dobos, Gábor Juhász   +9 more
wiley   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Leishmania cell surface prohibitin: role in host-parasite interaction

, 2010
Proteins selectively upregulated in infective parasitic forms could be critical for disease pathogenesis. A mammalian prohibitin orthologue is upregulated in infective metacyclic promastigotes of Leishmania donovani, a parasite that causes visceral ...
Jain, Rohit, Mandal, Chitra, Ghoshal, Angana, Shaha, Chandrima   +3 more
core   +1 more source

Prohibitin 1 Regulates Inflammatory Mediators and Reactive Oxygen Species in Retinal Endothelial Cells

, 2022
Diabetic retinopathy is associated with increased inflammatory mediator levels. In these studies, we focused on prohibitin 1. We performed western blotting for retinal lysates from diabetic mice and Epac1 floxed and cdh5Cre-Epac1 mice.
Youde Jiang, Li Liu, Jena J. Steinle
core   +1 more source

Detection of Ring Structure and Its Flexibility in Periplasmic Region of FliL, Bacterial Flagellar Stator‐Associate Protein, in Marine Vibrio

Molecular Microbiology, EarlyView.
FliL, a single‐pass transmembrane flagellar protein with a large periplasmic domain, associates with the basal body and supports motor function under high‐load conditions (e.g., viscous environments). The periplasmic domain of deletion mutant FliL forms a flexible ring structure, likely reflecting the capacity of the full‐length protein to adaptively ...
Tatsuro Nishikino, Norihiro Takekawa, Raymond Burton‐Smith, Yuki Tajimi, Kazuyoshi Murata, Takayuki Uchihashi, Seiji Kojima, Katsumi Imada, Michio Homma   +8 more
wiley   +1 more source