Results 41 to 50 of about 7,232 (211)

IL-10 Treatment Is Associated with Prohibitin Expression in the Crohn’s Disease Intestinal Fibrosis Mouse Model

Mediators of Inflammation, 2013
Prohibitin, which can inhibit oxidative stress and mitochondrial dysfunction, has been shown to have significant anti-inflammatory activities. Here, we investigate the effects of altering prohibitin levels in affected tissues in the interleukin-10 ...
C. Yuan, W.-X. Chen, J.-S. Zhu, N.-W. Chen, Y.-M. Lu, Y.-X. Ou, H.-Q. Chen   +6 more
doaj   +1 more source

Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy

Scientific Reports, 2023
Autophagy of damaged mitochondria, called mitophagy, is an important organelle quality control process involved in the pathogenesis of inflammation, cancer, aging, and age-associated diseases.
Kibrom M. Alula, Yaritza Delgado-Deida, Rosemary Callahan, Andreas Till, Lucia Underwood, Winston E. Thompson, Rhonda F. Souza, Themistocles Dassopoulos, Joseph Onyiah, K. Venuprasad, Arianne L. Theiss   +10 more
doaj   +1 more source

Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases

Frontiers in Genetics, 2021
A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins
Misa Belser, David W. Walker, David W. Walker   +2 more
doaj   +1 more source

Downregulation of lung mitochondrial prohibitin in COPD [PDF]

Respiratory Medicine, 2012
Prohibitins (PHB1 and PHB2) are versatile proteins located at the inner mitochondrial membrane, maintaining normal mitochondrial function and morphology. They interact with the NADH dehydrogenase protein complex, which is essential for oxidoreductase activity within cells. However, their expression in lung epithelium, especially in smokers and patients
Soulitzis, Nikolaos, Neofytou, Eirini, Psarrou, Maria, Anagnostis, Aristotelis, Tavernarakis, Nektarios, Siafakas, Nikolaos, Tzortzaki, Eleni G.   +6 more
openaire   +2 more sources

Proteomic analysis of the rat ovary following chronic low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [PDF]

, 2009
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine-disrupting chemical and reproductive toxicant. In order to elucidate low-dose TCDD-mediated effects on reproductive or endocrine functions, female Sprague-Dawley rats were
Chen, Xi, Chun-mei Zhang, Jing Liu, Ma, X.M., Zhang, C.M., Zhao, L.J., Zhang, Chun-mei, Chen, X., Li-jun Zhao, Sun, M., Ma, Xiao-ming, Coenraads, P.J., Tang, N.J., Liu, J., Tang, Nai-jun, Liu, Jing, Zhao, Li-jun, Xi Chen, Pieter-Jan Coenraads, Ma, S.W., Shi-wei Ma, Min Sun, Coenraads, Pieter-Jan, Xiao-ming Ma, Sun, Min, Ma, Shi-wei, Nai-jun Tang   +26 more
core   +1 more source

Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination

Frontiers in Cellular Neuroscience, 2017
Hippocampal neurogenesis persists throughout adult life and plays an important role in learning and memory. Although the influence of physical exercise on neurogenesis has been intensively studied, there is controversy in regard to how the impact of ...
Ji H. So, Chao Huang, Minyan Ge, Guangyao Cai, Lanqiu Zhang, Yisheng Lu, Yisheng Lu, Yisheng Lu, Yangling Mu, Yangling Mu, Yangling Mu   +10 more
doaj   +1 more source

The function of prohibitins in mitochondria and the clinical potentials

Cancer Cell International, 2022
AbstractProhibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria.
Linda Oyang, Jian Li, Xianjie Jiang, Jinguan Lin, Longzheng Xia, Lixia Yang, Shiming Tan, Nayiyuan Wu, Yaqian Han, Yiqing Yang, Xia Luo, Jinyun Li, Qianjin Liao, Yingrui Shi, Yujuan Zhou   +14 more
openaire   +3 more sources

Prohibitin participates in the HIRA complex to promote cell metastasis in breast cancer cell lines

FEBS Open Bio, 2020
Prohibitin (PHB) is a highly conserved, ubiquitously expressed, multifunctional protein with a well‐characterized function as a chaperone‐stabilizing mitochondrial proteins.
Xiaoqing Huang, Jinji Liu, Qinghui Ma
doaj   +1 more source

Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer

Cells, 2023
Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi, Lillie Lamont, Evelyn Liu, Sarina D. Murray, Xiangbing Meng, Shujie Yang   +5 more
doaj   +1 more source

The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. [PDF]

The EMBO Journal, 1994
The two major classes of antigen receptors on murine B lymphocytes, mIgM and mIgD, are both contained in a complex with two additional molecules, Ig-alpha and Ig-beta, which permit signal transduction. Accordingly, early biochemical events after antigen binding to either receptor are similar; biological effects, however, are different.
M, Terashima, K M, Kim, T, Adachi, P J, Nielsen, M, Reth, G, Köhler, M C, Lamers   +6 more
openaire   +2 more sources