Results 61 to 70 of about 7,558 (163)
Androgens target prohibitin to regulate proliferation of prostate cancer cells.
, 2004 Proteins involved in the growth response of prostate cancer cells to androgen were investigated by comparing the proteomes of LNCaP cells treated with vehicle or androgen. Whole-cell lysates were separated by two-dimensional PAGE, and HPLC-MS/MS was used
Gamble, SC +7 more
core +1 more source
Nano ExpressAnti-obesity drugs are limited in their application due to poor drug specificity, efficacy, and bystander side effects. The study reports on the use of bi-functionalized gold nanoparticles (AuNPs) to improve the selectivity and efficacy of therapeutic ...
Nicole R S Sibuyi +6 more
doaj +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
Functional Specialization of Clathrin‐Independent Endocytic Routes: Mechanisms and Cellular Roles
Traffic, Volume 27, Issue 3, September 2026.Distinct clathrin‐independent endocytic (CIE) routes support specialized cellular functions across different contexts. Created with Biorender.com. ABSTRACT Clathrin‐independent endocytosis (CIE) comprises a diverse repertoire of internalization mechanisms that operate in parallel with clathrin‐mediated endocytosis.
Andrea Francesco Benvenuto +5 more
wiley +1 more source
Prohibitin-Binding Proteins and their effects on Beta Cells.
, 2022 We are interested in the effect that prohibitin-binding proteins may have on pancreatic beta cells and insulin ...
Lutz, Lauren
core +2 more sources
MedComm, Volume 7, Issue 8, August 2026.Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong +8 more
wiley +1 more source
Prohibitin – At the crossroads of obesity-linked diabetes and cancer
, 2017 The promoter of a gene that is selectively expressed in just a few cell types provides unique opportunities to study: (1) the pleiotropic function of a protein in two different cell types including the cell compartment specific function, and (2) the ...
Suresh Mishra, BL Grégoire Nyomba
core +1 more source
Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. [PDF]
PLoS ONE, 2012 Increase in mitochondrial biogenesis has been shown to accompany brown and white adipose cell differentiation. Prohibitins (PHBs), comprised of two evolutionarily conserved proteins, prohibitin-1 (PHB1) and prohibitin-2 (PHB2), are present in a high ...
Dong Liu +9 more
doaj +1 more source
CRVP379 interacts with mosquito prohibitin during DENV infection.
, 2015 A. Prohibitin is required for DENV infection of Aedes aegypti. Mosquitoes were intra-thoracically injected with either dsRNA against the coding region of prohibitin (Prohdsrna) or dsRNA against GFP (gfpdsrna) as control.
Michael Ledizet (817185) +11 more
core +1 more source
The prohibitin family of mitochondrial proteins regulate replicative lifespan [PDF]
, 1997 Cellular senescence is determined by multiple factors, including the genetic regulation of metabolism and responses to endogenous and exogenous stresses [1-4]. Recent studies implicate a limited number of gene products in elongating lifespan in yeast and
Prescott, A. R. +9 more
core +1 more source