Results 51 to 60 of about 7,232 (211)
Advanced Science, 2022 Persistent uptake of high‐calorie diets induces the storage of excessive lipid in visceral adipose tissue. Lipids secreted from obese adipose tissue are accumulated in peripheral tissues such as the liver, pancreas, and muscle, and impair insulin ...
Juhyeong Hong, Yong‐Hee Kim
doaj +1 more source
Proteolytic control of mitochondrial protein translocases. [PDF]
Protein SciAbstract Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is continuously remodeled to meet changing cellular and environmental demands.
Kroczek L, Langer T.
europepmc +2 more sources
The Prohibitins: emerging roles in diverse functions [PDF]
Journal of Cellular and Molecular Medicine, 2006 The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name prohibitin.
Mishra, Suresh +2 more
openaire +2 more sources
Prohibitin Proteine: Chaperone der Mitochondrien und Adhäsion
, 2007 Title and Table of contents 1.1. Abstract 7 1.2. Zusammenfassung 8 2\. Introduction 9 3\. Objectives 25 4\. Results 26 5\. Discussion 49 6\. Materials 58 7\. Methods 69 7.1. Cell culture methods 69 7.2. Protein methods 78
Sievers, Claudia
core +1 more source
Peptide Adjuvant to Invigorate Cytolytic Activity of NK Cells in an Obese Mouse Cancer Model
Pharmaceutics, 2021 Cancer patients who are overweight compared to those with normal body weight have obesity-associated alterations of natural killer (NK) cells, characterized by poor cytotoxicity, slow proliferation, and inadequate anti-cancer activity.
Seungmin Han +8 more
doaj +1 more source
Prohibitin-1 Transgenic Mice Revealed an Important Role of Prohibitin in Testicular Steroidogenesis
Journal of the Endocrine Society, 2021 Abstract Testosterone, the male sex hormone, plays an important role in the sexual development and fertility. Consequently, its deficiency causes infertility, obesity, osteoporosis and cardiovascular diseases. Leydig cells (LCs) are the testicular interstitial cells responsible for the biosynthesis of testosterone in response to ...
Bassi, Geetika, Mishra, Suresh
openaire +1 more source
A Repressive Role for Prohibitin in Estrogen Signaling [PDF]
Molecular Endocrinology, 2008 Nuclear receptor-mediated gene expression is regulated by corepressors and coactivators. In this study we demonstrate that prohibitin (PHB), a potential tumor suppressor, functions as a potent transcriptional corepressor for estrogen receptor alpha (ERalpha).
Bin, He +7 more
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Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy
Clinical Genetics, EarlyView.A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk +13 more
wiley +1 more source
, 2022 Diabetic retinopathy is associated with increased inflammatory mediator levels. In these studies, we focused on prohibitin 1. We performed western blotting for retinal lysates from diabetic mice and Epac1 floxed and cdh5Cre-Epac1 mice.
Youde Jiang, Li Liu, Jena J. Steinle
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The sorting nexin Snx21 promotes flotillin‐mediated endocytosis
The FEBS Journal, EarlyView.In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs +9 more
wiley +1 more source