Results 51 to 60 of about 6,151 (175)
An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential
Cell Reports, 2018 Summary: Proteins of the stomatin/prohibitin/flotillin/HfIK/C (SPFH) family are membrane-anchored and perform diverse cellular functions in different organelles.
Joachim Michael Matz +3 more
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Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases
Frontiers in Genetics, 2021 A decline in mitochondrial function has long been associated with age-related health decline. Several lines of evidence suggest that interventions that stimulate mitochondrial autophagy (mitophagy) can slow aging and prolong healthy lifespan. Prohibitins
Misa Belser +2 more
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Downregulation of lung mitochondrial prohibitin in COPD [PDF]
Respiratory Medicine, 2012 Prohibitins (PHB1 and PHB2) are versatile proteins located at the inner mitochondrial membrane, maintaining normal mitochondrial function and morphology. They interact with the NADH dehydrogenase protein complex, which is essential for oxidoreductase activity within cells. However, their expression in lung epithelium, especially in smokers and patients
Soulitzis, Nikolaos +6 more
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Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination
Frontiers in Cellular Neuroscience, 2017 Hippocampal neurogenesis persists throughout adult life and plays an important role in learning and memory. Although the influence of physical exercise on neurogenesis has been intensively studied, there is controversy in regard to how the impact of ...
Ji H. So +10 more
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Prohibitin participates in the HIRA complex to promote cell metastasis in breast cancer cell lines
FEBS Open Bio, 2020 Prohibitin (PHB) is a highly conserved, ubiquitously expressed, multifunctional protein with a well‐characterized function as a chaperone‐stabilizing mitochondrial proteins.
Xiaoqing Huang, Jinji Liu, Qinghui Ma
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Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer
Cells, 2023 Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi +5 more
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The Prohibitins: emerging roles in diverse functions [PDF]
Journal of Cellular and Molecular Medicine, 2006 The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name prohibitin.
Mishra, Suresh +2 more
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The function of prohibitins in mitochondria and the clinical potentials
Cancer Cell International, 2022 AbstractProhibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways. PHBs have different subcellular localization in eukaryotes, but they are mainly located in mitochondria.
Linda Oyang +14 more
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Advanced Science, 2022 Persistent uptake of high‐calorie diets induces the storage of excessive lipid in visceral adipose tissue. Lipids secreted from obese adipose tissue are accumulated in peripheral tissues such as the liver, pancreas, and muscle, and impair insulin ...
Juhyeong Hong, Yong‐Hee Kim
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Prohibitin Is Involved in Patients with IgG4 Related Disease. [PDF]
PLoS ONE, 2015 IgG4-related disease (IgG4-RD) is a chronic systemic disease involved in many organs and tissues. As only limited autoantigens have been found since the beginning of this century, the aim of this study was to reveal new candidate autoantigens of IgG4-RD ...
Hongwu Du +8 more
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