Results 71 to 80 of about 7,232 (211)

Androgens target prohibitin to regulate proliferation of prostate cancer cells.

, 2004
Proteins involved in the growth response of prostate cancer cells to androgen were investigated by comparing the proteomes of LNCaP cells treated with vehicle or androgen. Whole-cell lysates were separated by two-dimensional PAGE, and HPLC-MS/MS was used
Gamble, SC, Dunn, MJ, Waxman, J, Odontiadis, M, Westbrook, JA, Wait, Robin, Lam, EW, Bevan, CL   +7 more
core   +1 more source

The Virulence Polysaccharide of Salmonella Typhi Suppresses Activation of Rho Family GTPases to Limit Inflammatory Responses From Epithelial Cells

Frontiers in Cellular and Infection Microbiology, 2019
Vi capsular polysaccharide (Vi) is a major virulence factor of human typhoid-causing pathogen Salmonella enterica serovar Typhi (S. Typhi). It distinguishes S. Typhi from closely related non-typhoidal Salmonella serovars such as S.
Farhat Parween, Jitender Yadav, Ayub Qadri   +2 more
doaj   +1 more source

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance

Nature Communications, 2021
How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for ...
Haohao Huang, Songyang Zhang, Yuanyuan Li, Zhaodan Liu, Lanjuan Mi, Yan Cai, Xinzheng Wang, Lishu Chen, Haowen Ran, Dake Xiao, Fangye Li, Jiaqi Wu, Tingting Li, Qiuying Han, Liang Chen, Xin Pan, Huiyan Li, Tao Li, Kun He, Ailing Li, Xuemin Zhang, Tao Zhou, Qing Xia, Jianghong Man   +23 more
doaj   +1 more source

Mass spectrometry proteomics for studying mitostasis

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Maintaining mitochondrial integrity and function is fundamental to cellular homeostasis. Cells rely on coordinated protein quality control (QC) systems—including intricate chaperone‐protease networks, the ubiquitin‐proteasome system, and cytosolic surveillance pathways—that together form a dynamic, cell‐wide mitostasis network governing the ...
Lakshita Sharma, Sristi Chakroborty, Hirak Das, Silke Oeljeklaus, Julian Bender, Bettina Warscheid   +5 more
wiley   +1 more source

Opposing function of mitochondrial prohibitin in aging

, 2016
This is an open‐access article distributed under the terms of the Creative Commons Attribution License.While specific signalling cascades involved in aging, such as the insulin/IGF‐1 pathway, are well‐described, the actual metabolic changes they elicit ...
Artal-Sanz, Marta, Tavernarakis, Nektarios   +1 more
core   +1 more source

Expression and prognostic value of prohibitin in gastrointestinal cancers based on bioinformatics

陆军军医大学学报
Objective To explore the expression of prohibitin (PHB) in tumor tissues and analyze its effect on the prognosis of patients with digestive system malignant tumor (DT) and its mechanism.
LI Xiaofeng, LIU Xixi, SONG Ziqing
doaj   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, Volume 13, Issue 33, 15 June 2026.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Prohibitin – At the crossroads of obesity-linked diabetes and cancer

, 2017
The promoter of a gene that is selectively expressed in just a few cell types provides unique opportunities to study: (1) the pleiotropic function of a protein in two different cell types including the cell compartment specific function, and (2) the ...
Suresh Mishra, BL Grégoire Nyomba
core   +1 more source

Characterisation and In Planta Activity of Bacteriophages That Infect the Key Bacterial Species Associated With Acute Oak Decline

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
Phages that infect the oak pathogens Brenneria goodwinii and Gibbsiella quercinecans were isolated. The phages were able to effectively reduce bacterial populations of their respective hosts in vitro. However, when applied in planta, the phages did not reduce host populations and instead phages and bacteria co‐existed over time.
Emily R. Grace, Vanja Milenkovic, Katherine G. Hinton, Sabrine Dhaouadi, Diana Vinchira‐Villarraga, Michael A. Brockhurst, Mojgan Rabiey, Robert W. Jackson   +7 more
wiley   +1 more source

Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. [PDF]

PLoS ONE, 2012
Increase in mitochondrial biogenesis has been shown to accompany brown and white adipose cell differentiation. Prohibitins (PHBs), comprised of two evolutionarily conserved proteins, prohibitin-1 (PHB1) and prohibitin-2 (PHB2), are present in a high ...
Dong Liu, Yiming Lin, Ting Kang, Bo Huang, Wei Xu, Minerva Garcia-Barrio, Moshood Olatinwo, Roland Matthews, Y Eugene Chen, Winston E Thompson   +9 more
doaj   +1 more source