Results 81 to 90 of about 7,232 (211)
Advanced Science, Volume 13, Issue 26, 8 May 2026.ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy +8 more
wiley +1 more source
Mitochondrial–Nuclear Communication by Prohibitin Shuttling under Oxidative Stress
, 2016 Mitochondrial–nuclear communication is critical for maintaining mitochondrial activity under stress conditions. Adaptation of the mitochondrial–nuclear network to changes in the intracellular oxidation and reduction milieu is critical for the survival of
Beth M. Elledge (2164291) +6 more
core +1 more source
Nano ExpressAnti-obesity drugs are limited in their application due to poor drug specificity, efficacy, and bystander side effects. The study reports on the use of bi-functionalized gold nanoparticles (AuNPs) to improve the selectivity and efficacy of therapeutic ...
Nicole R S Sibuyi +6 more
doaj +1 more source
CRVP379 interacts with mosquito prohibitin during DENV infection.
, 2015 A. Prohibitin is required for DENV infection of Aedes aegypti. Mosquitoes were intra-thoracically injected with either dsRNA against the coding region of prohibitin (Prohdsrna) or dsRNA against GFP (gfpdsrna) as control.
Michael Ledizet (817185) +11 more
core +1 more source
Skp2 and Skp2B team up against Rb and p53
Cell Division, 2011 The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established.
Germain Doris
doaj +1 more source
Immunoproteomic to identify antigens in the intestinal mucosa of Crohn's disease patients. [PDF]
PLoS ONE, 2013 Incidences of Crohn disease (CD) have increased significantly in the last decade. Immunoproteomics are a promising method to identify biomarkers of different diseases. In the present study, we used immunoproteomics to study proteins of intestinal mucosal
Zheng Zhou +6 more
doaj +1 more source
Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-β pathways
Journal of Ovarian Research, 2017 Background Ovarian epithelial tumor (OET) is a silent disease of late diagnosis and poor prognosis. Currently treatment options are limited and patient response to treatment is difficult to predict so there is a serious need to delineate the real ...
Nour M. El-Etreby +2 more
doaj +1 more source
Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4. [PDF]
PLoS ONE, 2011 We previously reported that the degradation of prohibitin by the SCF(Skp2B) ubiquitin ligase results in a defect in the activity of p53. We also reported that MMTV-Skp2B transgenic mice develop mammary gland tumors that are characterized by an increased ...
Harish Chander +4 more
doaj +1 more source
Quality control of protein import into mammalian mitochondria
Protein Science, Volume 35, Issue 5, May 2026.Abstract Mitochondrial function depends on the continuous import of hundreds of nuclear‐encoded proteins. Targeting and translocation of mitochondrial proteins is a multistep process that is inherently vulnerable to defects in cytosolic quality control systems as well as perturbations in mitochondrial protein import machinery and organelle function ...
Madeleine Goldstein +2 more
wiley +1 more source