Results 81 to 90 of about 7,558 (163)

Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function

Microbiology Spectrum
Respiratory viruses, such as influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remain major global health threats, and the emergence of drug-resistant variants underscores the urgent need for host-targeted ...
Masaki Shoji, Rina Hashimoto, Canan G. Nebigil, Kazuto Takegawa, Itsuki Tomita, Kensuke Nakaoka, Momiji Ishikawa, Yasufumi Matsumura, Miki Nagao, Tomoyuki Esumi, Etsuhisa Takahashi, Hiroshi Kido, Yasuo Shinohara, Laurent Désaubry, Kazuo Takayama, Takashi Kuzuhara   +15 more
doaj   +1 more source

Mitochondrial–Nuclear Communication by Prohibitin Shuttling under Oxidative Stress

, 2011
Mitochondrial-nuclear communication is critical for maintaining mitochondrial activity under stress conditions. Adaptation of the mitochondrial-nuclear network to changes in the intracellular oxidation and reduction milieu is critical for the survival of
Sripathi, Srinivas R., Elledge, Beth M., Joseph J. Smith, Atkinson, Cameron L., He, Weilue, Srinivas R. Sripathi, Wan Jin Jahng, Weilue He, Liu, Zhicong, Beth M. Elledge, Cameron L. Atkinson, Jahng, Wan Jin, Zhicong Liu, Smith, Joseph J.   +13 more
core   +1 more source

Prohibitin controls MRS2-Mediated mitochondrial Mg

Cell Reports
Summary: Mitochondrial magnesium ( m Mg 2+ ) is essential for cellular metabolism and bioenergetics, yet the mechanisms governing its transport remain poorly understood.
Soumya Maity, Manigandan Venkatesan, Adhishree Chidambaram, Sukanthathulse Uthayabalan, Louis Tung Faat Lai, Nicholas D. Clark, Abhinaya Lakkureddi, Karthik Ramachandran, Kristen Bentz, Ravi Ramalingam, Sanjana Sen, Moeez Akram, Susan T. Weintraub, Brij B. Singh, David Gius, Joseph A. Baur, Arianne L. Theiss, Jeffrey Caplan, Doreen Matthies, Peter B. Stathopulos, Muniswamy Madesh   +20 more
doaj   +1 more source

Prohibitin as the Molecular Binding Switch in the Retinal Pigment Epithelium

, 2016
Previously, our molecular binding study showed that prohibitin interacts with phospholipids, including phosphatidylinositide and cardiolipin.
Sripathi, Srinivas R., Moser, Trevor, Um, Ji Yeon, Lamoke, Folami, Bernstein, Paul S., Bartoli, Manuela, He, Weilue, Ramakrishna, Wusirika, Jahng, Wan Jin, Sylvester, O’Donnell D.   +9 more
core   +1 more source

Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases

Cells, 2019
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed, and are present in the nucleus, cytosol, and mitochondria.
Anna Signorile, Giuseppe Sgaramella, Francesco Bellomo, Domenico De Rasmo   +3 more
doaj   +1 more source

Prohibitin as an oxidative stress biomarker in the eye

, 2010
Identification of biomarker proteins in the retina and retinal pigment epithelium (RPE) under oxidative stress may imply new insights into signaling mechanisms of retinal degeneration at the molecular level.
Lee, Hyunju, Srinivas Sripathi, Sung Haeng Lee, Richard C. Hunt, Manuela Bartoli, Zhang, Ruonan, Hilal Arnouk, Wan Jin Jahng, Arnouk, Hilal, Ping Chen, William J.M. Hrushesky, Lee, Sung Haeng, Hyewon Chung, Ruonan Zhang, Chen, Ping, Hrushesky, William J.M., Bartoli, Manuela, Sripathi, Srinivas, Hyunju Lee, Hunt, Richard C., Chung, Hyewon, Jahng, Wan Jin   +21 more
core   +1 more source

“Prohibitin”g CRAF/MAPK Activation with Rocaglamides [PDF]

, 2012
Interaction with prohibitin (PHB) is required for full activation of CRAF kinase, the central member of the highly conserved RAS-CRAF-MAPK pathway. In this issue of Chemistry & Biology, Polier et al.
Rudel, Thomas, Rajalingam, Krishnaraj
core   +1 more source

Prohibitin is required for transcriptional repression by the WT1-BASP1 complex

, 2014
The Wilms’ tumor-1 protein (WT1) is a transcriptional regulator that can either activate or repress genes controlling cell growth, apoptosis and differentiation.
Roberts, S.G.E., Goodfellow, S J, Toska, E, Medler, K F, Shandilya, J, Roberts, S G E, Medler, K.F., Toska, E., Goodfellow, S. J., Shandilya, J.   +9 more
core   +1 more source

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major

Parasites & Vectors, 2018
Background Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin
Teresa Cruz-Bustos, Ana Karina Ibarrola-Vannucci, Isabel Díaz-Lozano, José Luis Ramírez, A. Osuna   +4 more
doaj   +1 more source

Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.

PLoS Genetics, 2012
Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined.
Carsten Merkwirth, Paola Martinelli, Anne Korwitz, Michela Morbin, Hella S Brönneke, Sabine D Jordan, Elena I Rugarli, Thomas Langer   +7 more
doaj   +1 more source