Results 101 to 110 of about 7,232 (211)

Studies on Fortilin-Prohibitin Interaction

, 2013
: Apoptosis, programmed cell death, is a tightly regulated process that occurs in development, in tissue maintenance and turnover, and in regulating the immune system.
Doan, Hung 1982-
core  

Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis

, 2019
Background Mitochondria are dynamic organelles that undergo fission and fusion. During cell stress, mitochondrial dynamics shift to fission, leading to mitochondrial fragmentation, membrane leakage, and apoptosis.
Han-Fei Ding, Yin, Xiao-Ming, Wang, Hong-Gang, Yoon, Yisang, Xiao, Xiao, Ding, Han-Fei, Yisang Yoon, Dong, Zheng, Hong-Gang Wang, Black, Stephen, Gao, Hua, Robert A. Kirken, Ruslan Rafikov, Sung-Gyu Cho, Huang, Shang, Xiao-Ming Yin, Hua Gao, Shang Huang, Wang, Shixuan, Cho, Sung-Gyu, Stephen Black, Xiao Xiao, Rafikov, Ruslan, Zheng Dong, Shixuan Wang, Kirken, Robert A.   +25 more
core   +1 more source

Prohibitins: A Critical Role in Mitochondrial Functions and Implication in Diseases

Cells, 2019
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed, and are present in the nucleus, cytosol, and mitochondria.
Anna Signorile, Giuseppe Sgaramella, Francesco Bellomo, Domenico De Rasmo   +3 more
doaj   +1 more source

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major

Parasites & Vectors, 2018
Background Leishmaniasis, a disease caused by parasites of the genus Leishmania, infects roughly 12 million people worldwide, with about two million new cases per year. Prohibitins (PHBs) are highly conserved proteins belonging to the stomatin-prohibitin
Teresa Cruz-Bustos, Ana Karina Ibarrola-Vannucci, Isabel Díaz-Lozano, José Luis Ramírez, A. Osuna   +4 more
doaj   +1 more source

Role of Prohibitins as Guardians of mitochondrial homeostasis

Mitochondrion
Mitochondria are complex organelles critical to the maintenance of cellular homeostasis. Central to this regulation are Prohibitins (PHBs), a novel set of proteins involved in several mitochondrial quality control pathways, including protein folding, biogenesis, and mitophagy.
Sabrina Champsi, David A. Hood
openaire   +2 more sources

Mitochondrial–Nuclear Communication by Prohibitin Shuttling under Oxidative Stress

, 2011
Mitochondrial-nuclear communication is critical for maintaining mitochondrial activity under stress conditions. Adaptation of the mitochondrial-nuclear network to changes in the intracellular oxidation and reduction milieu is critical for the survival of
Sripathi, Srinivas R., Elledge, Beth M., Joseph J. Smith, Atkinson, Cameron L., He, Weilue, Srinivas R. Sripathi, Wan Jin Jahng, Weilue He, Liu, Zhicong, Beth M. Elledge, Cameron L. Atkinson, Jahng, Wan Jin, Zhicong Liu, Smith, Joseph J.   +13 more
core   +1 more source

Prohibitin is required for transcriptional repression by the WT1-BASP1 complex

, 2014
The Wilms’ tumor-1 protein (WT1) is a transcriptional regulator that can either activate or repress genes controlling cell growth, apoptosis and differentiation.
Roberts, S.G.E., Goodfellow, S J, Toska, E, Medler, K F, Shandilya, J, Roberts, S G E, Medler, K.F., Toska, E., Goodfellow, S. J., Shandilya, J.   +9 more
core   +1 more source

CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription

Cellular Signalling, 2011
Prohibitin 2 (PHB2) is an evolutionarily conserved and ubiquitously expressed multifunctional protein which is present in various cellular compartments including the nucleus. However, mechanisms underlying various functions of PHB2 are not fully explored yet.
Sun, Luguo, Cao, Xia, Liu, Bin, Huang, Honglan, Wang, Xu, Sui, Liyan, Yin, Weimin, Ma, Kewei   +7 more
openaire   +2 more sources

Prohibitin-Binding Proteins and their effects on Beta Cells.

, 2022
We are interested in the effect that prohibitin-binding proteins may have on pancreatic beta cells and insulin ...
Lutz, Lauren
core  

Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.

PLoS Genetics, 2012
Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined.
Carsten Merkwirth, Paola Martinelli, Anne Korwitz, Michela Morbin, Hella S Brönneke, Sabine D Jordan, Elena I Rugarli, Thomas Langer   +7 more
doaj   +1 more source