Results 101 to 110 of about 7,558 (163)

Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans

, 2009
Marked alterations in cellular energy metabolism are a universal hallmark of the ageing process1. The biogenesis and function of mitochondria, the energy-generating organelles in eukaryotic cells, are primary longevity determinants.
Marta Artal-Sanz, Artal-Sanz, Marta, Tavernarakis, Nektarios, Nektarios Tavernarakis   +3 more
core   +1 more source

Generation and characterization of pancreatic ß-Cell specific Prohibitin-2 knockout mice

, 2013
Prohibitin-2 (Phb-2) controls mitochondrial dynamics and apoptosis. In pancreatic ß-cells, mitochondria play a pivotal role in the control of insulin secretion. In this work, we investigated the role of Prohibitin 2 (Phb2) and mitochondrial dynamics in ß-
Supale, Sachin
core   +1 more source

Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling.

PLoS ONE
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. They are ubiquitously expressed and implicated in the regulation of cell proliferation, migration,
Mei Li, Xiaoyan Hu, Xinxin Hu, Fuhua Gao, Ying Cui, Xiaoqing Wei, Yuanhua Qin, Xiaohua An, Ying Zhao, Ying Gao   +9 more
doaj   +1 more source

Preparation of constructs for overexpression and crystallisation of prohibitin complex from \kur{T.brucei}

, 2008
Aim of this work was to prepare plasmids for overexpression of prohibitin complex from T. brucei. To overexpress this protein complex full and truncated versions of two prohibitin genes were cloned into RSFDuet-1.
RŮŽIČKA, Petr
core  

Corrigendum: Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination

Frontiers in Cellular Neuroscience, 2019
Ji H. So, Chao Huang, Minyan Ge, Guangyao Cai, Lanqiu Zhang, Yisheng Lu, Yisheng Lu, Yisheng Lu, Yangling Mu, Yangling Mu, Yangling Mu   +10 more
doaj   +1 more source

Identification of Prohibitin (PHB) as an Entry Factor of Highly Pathogenic Coronaviruses Using Metabolic Glycoengineering and Photo-Crosslinking Techniques. [PDF]

Emerg Microbes Infect
Zhu X, Wang X, Wang Y, Wang X, Li Y, Hua L, Duan H, Yan R, Yuan T, Li J, Yuan Y, Zhang B, Zhou D, Xiao S.   +13 more
europepmc   +1 more source

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1-Driven Raf-ERK Pathway Activation Promotes Cardiomyocyte Mitosis. [PDF]

MedComm (2020)
Cao C, Ma B, Zhang J, Yang L, Liu Z, Li H, Song J, Zhang K, Li L, Fu J, Liu J.   +10 more
europepmc   +1 more source

Cryo-EM structure of the prohibitin complex in open conformation. [PDF]

Proc Natl Acad Sci U S A
Hong S, Guan Z, Zhang L, Zhuang J, Yan L, Liu Y, Liu Z, Wang Q, Yin P.   +8 more
europepmc   +1 more source

A novel small-molecule inhibitor TD6 targets prohibitin 1 (PHB1) and suppresses colorectal cancer pulmonary metastasis by destabilizing mitochondrial complex I. [PDF]

Redox Biol
Wang K, Xu P, Hu Y, Ji D, Shao G, Chen M, Yang Z, Yang Y, Chen Y, Chen X, Zhou J, Ye T, Xu J, Wang M, Zhang W, Ruan J, Zhang H, Li H, Wang W.   +18 more
europepmc   +1 more source

Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease. [PDF]

Nat Commun
Luo D, Zheng L, Lu MA, Chen Z, Wang P, Guo Q, Gao N.   +6 more
europepmc   +1 more source