Results 111 to 120 of about 7,232 (211)

Prohibitin expression and function in ethanol treated pancreatic beta-cells

, 2010
Type 2 diabetes is now recognized as a worldwide epidemic. Pancreatic beta-cell decompensation in the presence of insulin resistance is a major mechanism for the development of type 2 diabetes and may be triggered by mitochondrial dysfunction. Alcoholism
Lee, Jong Han
core  

Investigation of the Cry4B–Prohibitin interaction in Aedes aegypti cells

, 2012
Bacillus thuringiensis (Bt) produces insecticidal toxins active against insects. Cry4B, one of the major insecticidal toxins produced by Bt subsp. israelensis, is highly toxic to mosquitoes in the genus Aedes: the major vectors of dengue, yellow fever ...
Smith, Duncan R., Kuadkitkan, Atichat, Berry, Colin   +2 more
core   +1 more source

The prohibitin family of mitochondrial proteins regulate replicative lifespan

, 1997
Cellular senescence is determined by multiple factors, including the genetic regulation of metabolism and responses to endogenous and exogenous stresses [1-4]. Recent studies implicate a limited number of gene products in elongating lifespan in yeast and
Prescott, A. R., Jamieson, D.J., Coates, P. J., Jamieson, D. J., Prescott, A.R., Prescott, A. R.; id_orcid, Hall, P.A., Smart, K., Coates, P.J., Hall, P. A.   +9 more
core   +1 more source

Molecular characterization of a gene induced during wheat hypersensitive reaction to stripe rust

Biologia Plantarum, 2011
A novel gene induced during hypersensitive reaction (HIR) in wheat was identified using in silico cloning and designated as TaHIR2. The TaHIR2 gene was deduced to encode a 284-amino acid protein, whose molecular mass and isoelectric point (pI) were 31.05
G. Zhang, Y. -M. Li, Y. -F. Sun, J. -M. Wang, B. Liu, J. Zhao, J. Guo, L. -L. Huang, X. -M. Chen, Z. -S. Kang   +9 more
doaj   +1 more source

Prohibitins in infection: potential therapeutic targets

Future Microbiology
Prohibitins (PHBs) are members of a highly conserved family of proteins, including prohibitin1 and prohibitin2. These proteins are predominantly localized in mitochondria, the nucleus, and cell membranes, where they play critical roles in mitochondrial biogenesis, apoptosis, immune regulation, and other biological processes.
Chen, Nuo, Liu, Xiaolan, Wang, Lulu, Yu, Hui, Liu, Fangqian, Yuan, Mengran, Wang, Qimeng, Zhang, Tianyi, Zhou, Xiaoxiang, Wang, Hua, Ji, Zengjun, Shen, Hongxing   +11 more
openaire   +2 more sources

Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor

, 2019
Wilms' tumor is the most common type of childhood kidney cancer. To improve risk stratification and identify novel therapeutic targets for patients with Wilms' tumor, we used high-resolution mass spectrometry proteomics to identify urine tumor markers ...
Cifani, P., Gadd, S., Ryan, Jeremy, Ahmed, S., He, Y., Bradwin, G., Burns, Melissa, Dome, J.S., Gunasekera, S., Kentsis, Alex, Steen, H., MacArthur, I., Gaewsky, Lyvia, Hollmann, Travis J, Hollmann, T.J., Bradwin, Gary, Ortiz, Michael V, Ortiz, M.V., He, Ying, Mullen, E., Letai, Anthony, MacArthur, Ian, Henssen, Anton G, Gunasekera, Shehana, Mullen, Elizabeth, Naranjo, Arlene, Heaton, T., Gaewsky, L., LaQuaglia, Michael, Chi, Yueh-Yun, Henssen, A.G., Heaton, Todd, Dome, Jeffrey S, Burns, M., Chi, Y.Y., Steen, Hanno, Perlman, E., Cifani, Paolo, Kentsis, A., Gadd, Samantha, Ryan, J., Letai, A., LaQuaglia, M., Perlman, Elizabeth, Ahmed, Saima, Naranjo, A.   +45 more
core   +1 more source

Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids [PDF]

, 2023
BACKGROUND AND AIMS: IgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Trampert, David C, Vos, Harmjan R, Beuers, Ulrich, Kersten, Remco, Tolenaars, Dagmar, Hubers, Lowiek M, van de Graaf, Stan F J   +6 more
core  

Identification and Analysis of Prohibitin in B16 Mouse Melanoma Cells

, 2008
Prohibitin, a highly conserved protein found in eukaryotic cells, has been found in recent years to possess a wide variety of functions in the cell.
Francis, Christopher
core  

Investigating sex-related differences in renal tissues from prohibitin-1 knock-in mouse models

Biological sex-related differences are present in many aspects of renal biology and pathobiology. However, our knowledge of the underlying mechanisms is currently limited. Prohibitin-1 (PHB1) is an evolutionarily conserved pleiotropic protein. Transgenic
Bhatia, Yeshika
core  

“Prohibitin”g CRAF/MAPK Activation with Rocaglamides

, 2012
Interaction with prohibitin (PHB) is required for full activation of CRAF kinase, the central member of the highly conserved RAS-CRAF-MAPK pathway. In this issue of Chemistry & Biology, Polier et al.
Rudel, Thomas, Rajalingam, Krishnaraj
core   +1 more source