Results 91 to 100 of about 7,232 (211)

Prohibitin: a potential therapeutic target in tyrosine kinase signaling

, 2017
Prohibitin is a pleiotropic protein that has roles in fundamental cellular processes, such as cellular proliferation and mitochondrial housekeeping, and in cell- or tissue-specific functions, such as adipogenesis and immune cell functions.
Suresh Mishra, Yang Xin Zi Xu, Sudharsana Rao Ande   +2 more
core   +1 more source

Immunohistochemical assessment of epidermal growth factor receptor and prohibitin expression in “post-COVID” placentas: results of a comparative cross-sectional study

Репродуктивная эндокринология
Background. COVID-19 pandemic is accompanied by a considerable number of morbidity cases among pregnant women. Certain knowledge has been accumulated about the histopathological features of the placenta during SARS-CoV-2 infection.
G.S. Manasova, Y.O. Stasii
doaj   +1 more source

Homogenous and Microbeam X-Ray Radiation Induces Proteomic Changes in the Brains of Irradiated Rats and in the Brains of Nonirradiated Cage Mate Rats

Dose-Response, 2018
To evaluate microbeam radiation therapy (MRT), for brain tumor treatment, the bystander effect in nonirradiated companion animals was investigated.
Richard Smith, Jiaxi Wang, Colin Seymour, Cristian Fernandez-Palomo, Jennifer Fazzari, Elisabeth Schültke, Elke Bräuer-Krisch, Jean Laissue, Christian Schroll, Carmel Mothersill   +9 more
doaj   +1 more source

Age‐Associated Impairment of Paneth Cells Driven by microRNA‐152 Promotes Intestinal Epithelial Vulnerability to Pathological Stress

Aging Cell, Volume 25, Issue 5, May 2026.
Aging associated miR‐152 dysregulation plays a central role in the loss of Paneth cell homeostasis by inhibiting mitochondrial protein Prohibitin1 (PHB1) expression, which contributes to increased small intestinal vulnerability to pathological stresses. ABSTRACT Advanced age is a well‐known risk factor for severe complications in surgical patients with
Bridgette Warner, Haonan Zhao, Hongxia Chen, Amy VanderStoep, Ana S. G. Cunningham, Dongyoon Yoo, Hee K. Chung, Christine Brantner, Jennifer Coleman, Joungil Choi, Rosemary Kozar, Myriam Gorospe, Jian‐Ying Wang, Lan Xiao   +13 more
wiley   +1 more source

Mechanisms controlling the plasma membrane targeting and the nanodomain organization of the plant SPFH protein HIR2

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Plasma membranes (PM) contain myriads of diverse nanodomains that correspond to nanometric scale structures enriched in specific lipids and proteins acting as signaling/regulation hubs involved in diverse biological processes. So far, how PM nanodomains are formed and maintained in plant cells remains largely unknown.
Michal Daněk, Omar Hdedeh, Jesús Amo, Jessica Boutet, Michaela Neubergerová, Héla Safi, Anas Abuzeineh, Amanda Martín‐Barranco, Jean‐Bernard Fiche, Caroline Mercier, Baldwin Dumortier, Gabriel Krouk, Marcelo Nollmann, Roman Pleskot, Yohann Boutté, Véronique Santoni, Sébastien Mongrand, Alexandre Martinière, Enric Zelazny   +18 more
wiley   +1 more source

Opposing function of mitochondrial prohibitin in aging

Aging, 2010
While specific signalling cascades involved in aging, such as the insulin/IGF-1 pathway, are well-described, the actual metabolic changes they elicit to prolong lifespan remain obscure. Nevertheless, the tuning of cellular metabolism towards maximal survival is the molecular basis of longevity.
Artal-Sanz, Marta, Tavernarakis, Nektarios   +1 more
openaire   +4 more sources

Prohibitin as the Molecular Binding Switch in the Retinal Pigment Epithelium

, 2016
Previously, our molecular binding study showed that prohibitin interacts with phospholipids, including phosphatidylinositide and cardiolipin.
Sripathi, Srinivas R., Moser, Trevor, Um, Ji Yeon, Lamoke, Folami, Bernstein, Paul S., Bartoli, Manuela, He, Weilue, Ramakrishna, Wusirika, Jahng, Wan Jin, Sylvester, O’Donnell D.   +9 more
core   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

The role and therapeutic potential of prohibitin in disease

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Prohibitin 1 (PHB1), a pleiotropic protein in the cell, has been implicated in the regulation of proliferation, apoptosis, transcription, mitochondrial protein folding, and as a cell-surface receptor. This diverse array of functions of PHB1 is attributed to the cell type studied and its subcellular localization.
Theiss, Arianne L., Sitaraman, Shanthi V.   +1 more
openaire   +2 more sources

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source