Results 11 to 20 of about 7,232 (211)

In situ architecture of the human prohibitin complex. [PDF]

Nat Cell Biol
Abstract Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others 1, 2 . The human prohibitins PHB1 and
Lange F, Ratz M, Dohrke JN, Le Vasseur M, Wenzel D, Ilgen P, Riedel D, Jakobs S.   +7 more
europepmc   +8 more sources

An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential [PDF]

Cell Reports, 2018
Summary: Proteins of the stomatin/prohibitin/flotillin/HfIK/C (SPFH) family are membrane-anchored and perform diverse cellular functions in different organelles.
Joachim Michael Matz, Christian Goosmann, Kai Matuschewski, Taco Wilhelmus Antonius Kooij   +3 more
doaj   +2 more sources

Prohibitin 2: At a communications crossroads

IUBMB Life, 2015
AbstractProhibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators
Bavelloni A, Piazzi M, Raffini M, Faenza I, Blalock WL   +4 more
openaire   +3 more sources

Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells [PDF]

Nature Communications, 2021
Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and ...
Gustavo Della-Flora Nunes, Emma R. Wilson, Leandro N. Marziali, Edward Hurley, Nicholas Silvestri, Bin He, Bert W. O’Malley, Bogdan Beirowski, Yannick Poitelon, Lawrence Wrabetz, M. Laura Feltri   +10 more
doaj   +2 more sources

Prohibitin as an oxidative stress biomarker in the eye [PDF]

International Journal of Biological Macromolecules, 2010
Identification of biomarker proteins in the retina and retinal pigment epithelium (RPE) under oxidative stress may imply new insights into signaling mechanisms of retinal degeneration at the molecular level. Proteomic data from an in vivo mice model in constant light and an in vitro oxidative stress model are compared to controls under normal ...
Hyunju, Lee, Hilal, Arnouk, Srinivas, Sripathi, Ping, Chen, Ruonan, Zhang, Manuela, Bartoli, Richard C, Hunt, William J M, Hrushesky, Hyewon, Chung, Sung Haeng, Lee, Wan Jin, Jahng   +10 more
openaire   +3 more sources

Prohibitin Is Involved in Patients with IgG4 Related Disease. [PDF]

PLoS ONE, 2015
IgG4-related disease (IgG4-RD) is a chronic systemic disease involved in many organs and tissues. As only limited autoantigens have been found since the beginning of this century, the aim of this study was to reveal new candidate autoantigens of IgG4-RD ...
Hongwu Du, Lili Shi, Peng Chen, Weikang Yang, Yiping Xun, Chunhe Yang, Lanqing Zhao, Yabin Zhou, Guangyu Chen   +8 more
doaj   +2 more sources

Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids [PDF]

Frontiers in Immunology
Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Remco Kersten, David C. Trampert, Lowiek M. Hubers, Dagmar Tolenaars, Harmjan R. Vos, Stan F. J. van de Graaf, Ulrich Beuers   +6 more
doaj   +2 more sources

Prohibitin is involved in mitochondrial biogenesis in plants

The Plant Journal, 2006
SummaryProhibitin, which consists of two subunits PHB1 and PHB2, plays a role in cell‐cycle progression, senescence, apoptosis, and maintenance of mitochondrial function in mammals and yeast. In this study, we examined the role of prohibitins in plants by using virus‐induced gene silencing (VIGS) of two prohibitin subunit genes of Nicotiana benthamiana,
Chang Sook, Ahn, Jeong Hee, Lee, A, Reum Hwang, Woo Taek, Kim, Hyun-Sook, Pai   +4 more
openaire   +3 more sources

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1-Driven Raf-ERK Pathway Activation Promotes Cardiomyocyte Mitosis. [PDF]

MedComm (2020)
SalB binds to the C‐terminal of PHB1/2 heterodimer, inducing a conformational change that enhances Raf‐ERK pathway activation via Akt‐mediated phosphorylation, thereby promoting cardiomyocyte mitosis. ABSTRACT Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic ...
Cao C, Ma B, Zhang J, Yang L, Liu Z, Li H, Song J, Zhang K, Li L, Fu J, Liu J.   +10 more
europepmc   +2 more sources

MICOS and MIMAS, multifunctional assemblies linking mitochondrial biogenesis, architecture, and function. [PDF]

Protein Sci
Abstract Mitochondrial cristae architecture is central for optimal oxidative phosphorylation and a healthy mitochondrial physiology. The intricate architecture of the inner mitochondrial membrane relies on protein complexes that compartmentalize the membrane by imposing membrane curvature, forming membrane contact sites or membrane subdomains ...
Horten P, Song K, Pfanner N, Rampelt H.
europepmc   +2 more sources