Results 21 to 30 of about 1,827 (179)

Prohibitions in the meta-inflammatory response: a review [PDF]

Frontiers in Molecular Biosciences
Prohibitins are the central regulatory element of cellular homeostasis, especially by modulating the response at different levels: Nucleus, mitochondria and membranes.
Natalia Todosenko, Kristina Yurova, Maria Vulf, Olga Khaziakhmatova, Larisa Litvinova, Larisa Litvinova   +5 more
doaj   +2 more sources

Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance [PDF]

Microbiology Spectrum
The SPFH (stomatin, prohibitin, flotillin, and HflK/HflC) protein superfamily is conserved across all domains of life. Fungal SPFH proteins are required for respiration, stress adaptation, and membrane scaffolding. In the yeast Candida albicans, stomatin-
Hyunjeong Kim, Marienela Y. Heredia, Xiao Chen, Maisha Ahmed, Mohammad Qasim, Tracy L. Callender, Aaron D. Hernday, Jason M. Rauceo   +7 more
doaj   +2 more sources

Comparative effects of antimalarial drugs on oxidative phosphorylation, mitochondrial dynamics and mitophagy in Plasmodium berghei-infected mice [PDF]

Toxicology Reports
Mitochondria occupy prominent position in cell metabolism. Information on changes in host mitochondrial capacity in electron transport system, dynamics and mitophagy in mice infected with resistant Plasmodium berghei and thereafter treated with some ...
John Oludele Olanlokun, Oluseye Osovehe Yahaya, Cecilia Opeyemi Babarinde, Oluwakemi Marvellous Oloke, Paul Steenkamp, Gerhard Prinsloo   +5 more
doaj   +2 more sources

The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation [PDF]

BMC Oral Health
Background Periodontitis is an inflammatory disease causing destruction of periodontal tissues. Controlling inflammation is crucial for periodontitis treatment. Prohibitins (PHBs) are emerging targets in the treatment of inflammatory diseases.
Céline Stutz, Pierre-Yves Gegout, Chloé Bloch, Hayriye Özçelik, Nicolas Anton, Redouane Tabti, Laurent Désaubry, Olivier Huck, Catherine Petit   +8 more
doaj   +2 more sources

Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins [PDF]

Frontiers in Immunology
IntroductionThe intracellular proliferation of Neospora caninum tachyzoites and the host immune response against infection are key steps in the pathogenesis of neosporosis. However, the molecules responsible for the activation of the inflammasome induced
Yu Chen, Naomi Shimoda, Coh-ichi Nihei, Ryuichi Sawa, Yuko Takahashi, Mitsuhiro Nishigori, Shu Nakamura, Jingwei Liu, Takumi Koshiba, Nanako Ushio-Watanabe, Yoshifumi Nishikawa   +10 more
doaj   +2 more sources

Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids [PDF]

Frontiers in Immunology, 2023
Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Remco Kersten, David C. Trampert, Lowiek M. Hubers, Dagmar Tolenaars, Harmjan R. Vos, Stan F. J. van de Graaf, Ulrich Beuers   +6 more
doaj   +2 more sources

The SPFH complex HflK-HflC regulates aerobic respiration in bacteria. [PDF]

PLoS Biology
The bacterial HflK-HflC membrane complex is a member of the highly conserved family of SPFH proteins, which are present in all domains of life and include eukaryotic stomatins, flotillins, and prohibitins.
María Isabel Pérez-López, Paul Lubrano, Georgia Angelidou, Sarah Hoch, Timo Glatter, Nicole Paczia, Hannes Link, Victor Sourjik   +7 more
doaj   +2 more sources

Prohibitins: emerging host targets of bacteria and viruses at the plasma membrane, mitochondria, and cytoplasm [PDF]

Microbial Cell
Ubiquitously expressed Prohibitin-1 (PHB1) and Prohibitin-2 (PHB2) serve pleiotropic functions in cellular processes, including signal transduction, mitochondrial metabolism and dynamics, and lipid raft formation. Located in phospholipid-rich subcellular
Grecia O. Rivera-Palomino, Arianne L. Theiss   +1 more
doaj   +2 more sources

Prohibitins and the functional compartmentalization of mitochondrial membranes [PDF]

Journal of Cell Science, 2009
Prohibitins constitute an evolutionarily conserved and ubiquitously expressed family of membrane proteins that are essential for cell proliferation and development in higher eukaryotes. Roles for prohibitins in cell signaling at the plasma membrane and in transcriptional regulation in the nucleus have been proposed, but pleiotropic defects associated ...
C. Osman, C. Merkwirth, T. Langer
openaire   +5 more sources

Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins

iScience, 2023
Summary: 5′-Adenosine monophosphate-activated protein kinase (AMPK) is a potential therapeutic target for various medical conditions. We here identify a small-molecule compound (RX-375) that activates AMPK and inhibits fatty acid synthesis in cultured ...
Shuhei Kanagaki, Yusuke Tsutsui, Naoki Kobayashi, Takashi Komine, Minoru Ito, Yunike Akasaka, Michiaki Nagasawa, Tomohiro Ide, Naoki Omae, Kazuhisa Nakao, Makoto Rembutsu, Maki Iwago, Aki Yonezawa, Yusei Hosokawa, Tetsuya Hosooka, Wataru Ogawa, Koji Murakami   +16 more
doaj   +2 more sources