Comparative effects of antimalarial drugs on oxidative phosphorylation, mitochondrial dynamics and mitophagy in Plasmodium berghei-infected mice [PDF]
Toxicology ReportsMitochondria occupy prominent position in cell metabolism. Information on changes in host mitochondrial capacity in electron transport system, dynamics and mitophagy in mice infected with resistant Plasmodium berghei and thereafter treated with some ...
John Oludele Olanlokun +5 more
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Functions of J‐domain proteins in mitochondrial protein biogenesis [PDF]
Protein Science, Volume 35, Issue 4, April 2026.Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Vitasta Tiku +3 more
wiley +2 more sources
The prohibitin ligand IN44 decreases Porphyromonas gingivalis mediated inflammation [PDF]
BMC Oral HealthBackground Periodontitis is an inflammatory disease causing destruction of periodontal tissues. Controlling inflammation is crucial for periodontitis treatment. Prohibitins (PHBs) are emerging targets in the treatment of inflammatory diseases.
Céline Stutz +8 more
doaj +2 more sources
Mitochondrial damage and IL-1β production in monocytes caused by Neospora caninum infection are mediated by dense granule protein 7 and prohibitins [PDF]
Frontiers in ImmunologyIntroductionThe intracellular proliferation of Neospora caninum tachyzoites and the host immune response against infection are key steps in the pathogenesis of neosporosis. However, the molecules responsible for the activation of the inflammasome induced
Yu Chen +10 more
doaj +2 more sources
The SPFH complex HflK-HflC regulates aerobic respiration in bacteria. [PDF]
PLoS BiologyThe bacterial HflK-HflC membrane complex is a member of the highly conserved family of SPFH proteins, which are present in all domains of life and include eukaryotic stomatins, flotillins, and prohibitins.
María Isabel Pérez-López +7 more
doaj +2 more sources
FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity. [PDF]
PLoS ONE, 2015 The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavaglines are natural products that have both potent anticancer and cardioprotective properties.
Rehana Qureshi +7 more
doaj +2 more sources
The Effect of Prohibitins on Mitochondrial Function during Octopus tankahkeei Spermiogenesis. [PDF]
Int J Mol Sci, 2023 Mitochondria are essential for spermiogenesis. Prohibitins (PHBs; prohibitin 1, PHB1 or PHB, and prohibitin 2, PHB2) are evolutionarily conserved and ubiquitously expressed mitochondrial proteins that act as scaffolds in the inner mitochondrial membrane.
Wang J +5 more
europepmc +2 more sources
Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids [PDF]
Frontiers in Immunology, 2023 Background and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Remco Kersten +6 more
doaj +2 more sources
Age‐Associated Impairment of Paneth Cells Driven by microRNA‐152 Promotes Intestinal Epithelial Vulnerability to Pathological Stress [PDF]
Aging Cell, Volume 25, Issue 5, May 2026.Aging associated miR‐152 dysregulation plays a central role in the loss of Paneth cell homeostasis by inhibiting mitochondrial protein Prohibitin1 (PHB1) expression, which contributes to increased small intestinal vulnerability to pathological stresses. ABSTRACT Advanced age is a well‐known risk factor for severe complications in surgical patients with
Bridgette Warner +13 more
wiley +2 more sources
mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage [PDF]
Cell Communication and SignalingIntroduction Cardiac mitochondrial function is intricately regulated by various processes, ultimately impacting metabolic performance. Additionally, protein turnover is crucial for sustained metabolic homeostasis in cardiomyocytes.
Hugo E. Verdejo +14 more
doaj +2 more sources