Results 31 to 40 of about 1,827 (179)

Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease [PDF]

Nature Communications
Mitochondrial function critically depends on protein quality control systems, with the m-AAA protease playing a key role at the inner mitochondrial membrane (IMM).
Dingyi Luo, Lvqin Zheng, Ming-Ao Lu, Ziyao Chen, Panpan Wang, Qiang Guo, Ning Gao   +6 more
doaj   +2 more sources

The function of prohibitins in mitochondria and the clinical potentials

Cancer Cell International, 2022
Prohibitins (PHBs) are a class of highly evolutionarily conserved proteins that widely distribute in prokaryotes and eukaryotes. PHBs function in cell growth and proliferation or differentiation, regulating metabolism and signaling pathways.
Linda Oyang, Jian Li, Xianjie Jiang, Jinguan Lin, Longzheng Xia, Lixia Yang, Shiming Tan, Nayiyuan Wu, Yaqian Han, Yiqing Yang, Xia Luo, Jinyun Li, Qianjin Liao, Yingrui Shi, Yujuan Zhou   +14 more
doaj   +3 more sources

FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity. [PDF]

PLoS ONE, 2015
The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavaglines are natural products that have both potent anticancer and cardioprotective properties.
Rehana Qureshi, Onur Yildirim, Adeline Gasser, Christine Basmadjian, Qian Zhao, Jean-Philippe Wilmet, Laurent Désaubry, Canan G Nebigil   +7 more
doaj   +2 more sources

mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage [PDF]

Cell Communication and Signaling
Introduction Cardiac mitochondrial function is intricately regulated by various processes, ultimately impacting metabolic performance. Additionally, protein turnover is crucial for sustained metabolic homeostasis in cardiomyocytes.
Hugo E. Verdejo, Valentina Parra, Andrea del Campo, Cesar Vasquez-Trincado, Damian Gatica, Camila Lopez-Crisosto, Jovan Kuzmicic, Leslye Venegas-Zamora, Ursula Zuñiga-Cuevas, Mayarling F. Troncoso, Rodrigo Troncoso, Beverly A. Rothermel, Mario Chiong, E. Dale Abel, Sergio Lavandero   +14 more
doaj   +2 more sources

In situ architecture of the human prohibitin complex. [PDF]

Nat Cell Biol
Abstract Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle progression, apoptosis, lifespan regulation and many others 1, 2 . The human prohibitins PHB1 and
Lange F, Ratz M, Dohrke JN, Le Vasseur M, Wenzel D, Ilgen P, Riedel D, Jakobs S.   +7 more
europepmc   +7 more sources

The Role of Prohibitin-2 in Diseases

Frontiers in Bioscience-Landmark, 2023
Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis. Recently, there has been growing interest in the biological function of PHB2.
Fang Liu, You Zhang, Zhiyong Guo, An-Jing Ren   +3 more
openaire   +3 more sources

Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling

Antioxidants, 2023
Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under cardiac stress remains poorly understood.
Kaina Zhang, Yeqing Zheng, Gaowa Bao, Wenzhuo Ma, Bing Han, Hongwen Shi, Zhenghang Zhao   +6 more
doaj   +1 more source

Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy. [PDF]

Clin Genet
A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Volk M, Maver A, Vidmar MJ, Trošt N, Višnjar T, Fakin A, Kovač L, Habjan MŠ, Malinar L, Pajić SP, Jerman UD, Romih R, Hawlina M, Peterlin B.   +13 more
europepmc   +2 more sources

Mitophagy: Permitted by Prohibitin [PDF]

Current Biology, 2017
Autophagic responses specific for damaged or superfluous mitochondria are crucial for the maintenance of cellular and organismal homeostasis. Recent data demonstrate that components of the inner mitochondrial membrane that are unmasked upon outer membrane permeabilization facilitate the autophagic destruction of the organelle.
Lorenzo, Galluzzi, José Manuel, Bravo-San Pedro, Guido, Kroemer   +2 more
openaire   +2 more sources

Mitochondrial prohibitin complex regulates fungal virulence via ATG24-assisted mitophagy

Communications Biology, 2022
Prohibitins recruit ChATG24 into the mitochondria to modulate mitophagy, thereby affecting the virulence of Colletotrichum higginsianum.
Yaqin Yan, Jintian Tang, Qinfeng Yuan, Caiyun Liu, Xiaolin Chen, Hao Liu, Junbin Huang, Chonglai Bao, Tom Hsiang, Lu Zheng   +9 more
doaj   +1 more source