Results 41 to 50 of about 1,827 (179)
Prohibitin and mitochondrial biology [PDF]
Trends in Endocrinology & Metabolism, 2009 Prohibitins are ubiquitous, evolutionarily conserved proteins that are mainly localized in mitochondria. The mitochondrial prohibitin complex comprises two subunits, PHB1 and PHB2. These two proteins assemble into a ring-like macromolecular structure at the inner mitochondrial membrane and are implicated in diverse cellular processes: from ...
Artal-Sanz, Marta +1 more
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The role of prohibitin in cell signaling [PDF]
The FEBS Journal, 2010 Prohibitin‐1 (PHB, also known as PHB1), a member of the Band‐7 family of proteins, is highly conserved evolutionarily, widely expressed, and present in different cellular compartments. Genetic studies with different organism models have provided strong evidence for an important biological role of PHB in mitochondrial function, cell proliferation, and ...
Suresh, Mishra +2 more
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Unveiling the potential of prohibitin in cancer [PDF]
Cancer Letters, 2015 Recently, research has shed new light on the role of Prohibitin (PHB) in cancer pathogenesis across an array of cancer types. Important mechanisms for PHB have been unveiled in several cancers, especially with regard to the androgen independent state of prostate cancer (PC) and oestrogen dependent breast cancer.
Koushyar, Sarah +2 more
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Redox Biology, 2021 Background: Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are linked to several mitochondrial alterations. Cigarette smoke (CS) alters the structure and function of mitochondria.
Krishna Prahlad Maremanda +2 more
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Mitochondrial Quality Control Mechanisms and the PHB (Prohibitin) Complex
Cells, 2018 Mitochondrial functions are essential for life, critical for development, maintenance of stem cells, adaptation to physiological changes, responses to stress, and aging.
Blanca Hernando-Rodríguez +1 more
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The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin‐related protein. [PDF]
The EMBO Journal, 1994 The two major classes of antigen receptors on murine B lymphocytes, mIgM and mIgD, are both contained in a complex with two additional molecules, Ig-alpha and Ig-beta, which permit signal transduction. Accordingly, early biochemical events after antigen binding to either receptor are similar; biological effects, however, are different.
M, Terashima +6 more
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Ras-Raf Signaling Needs Prohibitin [PDF]
Cell Cycle, 2005 Prohibitin has been connected to diverse cellular functions including cell cycle control, senescence, apoptosis and stabilization of mitochondrial proteins. By employing a loss of function approach using siRNAs we have demonstrated an unexpected role of PHB in the activation of Raf/MEK/ERK pathway by active Ras and in modulating epithelial cell ...
Rajalingam, K., Rudel, T.
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Involvement of prohibitin 1 and prohibitin 2 upregulation in cBSA-induced podocyte cytotoxicity
Journal of Food and Drug Analysis, 2020 Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, when not effectively treated. The aim of this study was to discover new targets for the diagnosis and treatment of MN. A reliable mouse model of MN was used by the administration of cationic bovine serum albumin (cBSA).
Heng-Hsiung Wu +3 more
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Haematologica, 2017 Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia ...
Ana M. Cosialls +12 more
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Role of prohibitins for proteolysis in yeast and murine mitochondria [PDF]
, 2006 Prohibitins, Phb1 and Phb2, are evolutionary conserved proteins with diverse cellular localization and different functions. In yeast, prohibitins form a high molecular weight complex in the inner mitochondrial membrane which physically interacts with the
Metodiev, Metodi Dimitrov
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