Results 61 to 70 of about 1,545 (164)

Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy

Clinical Genetics, Volume 110, Issue 2, Page 165-171, August 2026.
A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk, Aleš Maver, Martina Jarc Vidmar, Nuša Trošt, Tanja Višnjar, Ana Fakin, Lea Kovač, Maja Šuštar Habjan, Lucija Malinar, Sanja Petrović Pajić, Urška Dragin Jerman, Rok Romih, Marko Hawlina, Borut Peterlin   +13 more
wiley   +1 more source

A Repressive Role for Prohibitin in Estrogen Signaling [PDF]

Molecular Endocrinology, 2008
Nuclear receptor-mediated gene expression is regulated by corepressors and coactivators. In this study we demonstrate that prohibitin (PHB), a potential tumor suppressor, functions as a potent transcriptional corepressor for estrogen receptor alpha (ERalpha).
Bin, He, Qin, Feng, Atish, Mukherjee, David M, Lonard, Francesco J, DeMayo, Benita S, Katzenellenbogen, John P, Lydon, Bert W, O'Malley   +7 more
openaire   +2 more sources

Characterisation of detergent-insoluble membranes in pollen tubes of Nicotiana tabacum (L.)

Biology Open, 2015
Pollen tubes are the vehicle for sperm cell delivery to the embryo sac during fertilisation of Angiosperms. They provide an intriguing model for unravelling mechanisms of growing to extremes.
Alessandra Moscatelli, Assunta Gagliardi, Lilly Maneta-Peyret, Luca Bini, Nadia Stroppa, Elisabetta Onelli, Claudia Landi, Monica Scali, Aurora Irene Idilli, Patrick Moreau   +9 more
doaj   +1 more source

Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region

iScience, 2019
Summary: The coiled-coil motif mediates subunit oligomerization and scaffolding and underlies several fundamental biologic processes. Prohibitins (PHBs), mitochondrial inner membrane proteins involved in mitochondrial homeostasis and signal transduction,
Takahiro Yoshinaka, Hidetaka Kosako, Takuma Yoshizumi, Ryo Furukawa, Yu Hirano, Osamu Kuge, Taro Tamada, Takumi Koshiba   +7 more
doaj   +1 more source

Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans. [PDF]

PLoS ONE, 2014
Lifespan regulation by mitochondrial proteins has been well described, however, the mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins profoundly affecting ageing are prohibitins (PHB-1 and PHB-2).
Roxani Gatsi, Bettina Schulze, María Jesús Rodríguez-Palero, Blanca Hernando-Rodríguez, Ralf Baumeister, Marta Artal-Sanz   +5 more
doaj   +1 more source

Exploring thylakoid emergence: evolution of membrane biogenesis and photosystem II assembly in early‐diverging cyanobacteria

New Phytologist, Volume 251, Issue 3, Page 1329-1343, August 2026.
Overview of the results. Phylogenetic analyses of 36 assembly factors of photosystem II (PSII) and 13 proteins involved in membrane dynamics summarized in Siebenaller & Schneider (2023) were performed to investigate the taxonomic distributions and structural differences between the thylakoid‐less Gloeobacterales and the Phycobacteria. Summary Thylakoid
Louise Hambücken, Denis Baurain, Luc Cornet   +2 more
wiley   +1 more source

Host-directed antiviral strategy targeting prohibitins: Mel56 suppresses influenza A virus and severe acute respiratory syndrome coronavirus 2 via modulation of antioxidant pathways and mitochondrial function

Microbiology Spectrum
Respiratory viruses, such as influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remain major global health threats, and the emergence of drug-resistant variants underscores the urgent need for host-targeted ...
Masaki Shoji, Rina Hashimoto, Canan G. Nebigil, Kazuto Takegawa, Itsuki Tomita, Kensuke Nakaoka, Momiji Ishikawa, Yasufumi Matsumura, Miki Nagao, Tomoyuki Esumi, Etsuhisa Takahashi, Hiroshi Kido, Yasuo Shinohara, Laurent Désaubry, Kazuo Takayama, Takashi Kuzuhara   +15 more
doaj   +1 more source

SARS‐CoV‐2 and Cancer Biology: Exploring the Mechanistic Links

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Five years after the emergence of SARS‐CoV‐2 and the declaration of the COVID‐19 pandemic, the long‐term implications of COVID‐19 for cancer biology remain incompletely understood. Beyond the major disruptions in cancer screening, diagnosis, and treatment observed worldwide, increasing attention has focused on whether SARS‐CoV‐2 ...
Andrea Orue, Alejandro Cornejo, Héctor Rafael Rangel   +2 more
wiley   +1 more source

Prohibitins and the functional compartmentalization of mitochondrial membranes [PDF]

Journal of Cell Science, 2009
Prohibitins constitute an evolutionarily conserved and ubiquitously expressed family of membrane proteins that are essential for cell proliferation and development in higher eukaryotes. Roles for prohibitins in cell signaling at the plasma membrane and in transcriptional regulation in the nucleus have been proposed, but pleiotropic defects associated ...
C. Osman, C. Merkwirth, T. Langer
openaire   +4 more sources

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source