Results 81 to 90 of about 1,728 (183)

Recent advances in pancreatic β‐cell dysfunction in type 2 diabetes mellitus: Intracellular stress and dedifferentiation

Journal of Diabetes Investigation, EarlyView.
Nozomi Kido, Shun‐ichiro Asahara
wiley   +1 more source

Mechanisms controlling the plasma membrane targeting and the nanodomain organization of the plant SPFH protein HIR2

The Plant Journal, Volume 126, Issue 3, May 2026.
SUMMARY Plasma membranes (PM) contain myriads of diverse nanodomains that correspond to nanometric scale structures enriched in specific lipids and proteins acting as signaling/regulation hubs involved in diverse biological processes. So far, how PM nanodomains are formed and maintained in plant cells remains largely unknown.
Michal Daněk, Omar Hdedeh, Jesús Amo, Jessica Boutet, Michaela Neubergerová, Héla Safi, Anas Abuzeineh, Amanda Martín‐Barranco, Jean‐Bernard Fiche, Caroline Mercier, Baldwin Dumortier, Gabriel Krouk, Marcelo Nollmann, Roman Pleskot, Yohann Boutté, Véronique Santoni, Sébastien Mongrand, Alexandre Martinière, Enric Zelazny   +18 more
wiley   +1 more source

Evolution of prokaryotic SPFH proteins. [PDF]

, 2009
BACKGROUND: The SPFH protein superfamily is a diverse family of proteins whose eukaryotic members are involved in the scaffolding of detergent-resistant microdomains. Recently the origin of the SPFH proteins has been questioned.
Reuter Alexander, Markus Hinderhofer, Möller, Heiko M., Möller Heiko M, Hinderhofer Markus, Hinderhofer, Markus, Heiko M Möller, Walker, Christina A, Walker Christina A, Christina A Walker, Stuermer, Claudia AO, Friemel, Anke, Möller, Heiko M, Claudia AO Stuermer, Walker, Christina A., Alexander Reuter, Friemel Anke, Reuter, Alexander, Anke Friemel, Claudia AO Sturmer, Stuermer Claudia AO, Stürmer, Claudia   +21 more
core   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

Resonant Recognition Model Study for Interactions between SARS CoV 2 and Human Proteins

Revista Cubana de Informática Médica, 2020
Este estudio se dedicó al análisis mediante el  Modelo de Reconocimiento Resonante (RRM) de las proteínas del SARS-CoV-2 y su posible interacción con otras proteínas humanas, específicamente, fueron analizadas las replicasas de SARS CoV y las ...
Susana Margarita Montesino Castillo, Cristóbal Yera Gálvez, José Luis Hernández Cáceres   +2 more
doaj  

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis

Cell Reports, 2018
Summary: The root stem cell niche, which is composed of four mitotically inactive quiescent center (QC) cells and the surrounding actively divided stem cells in Arabidopsis, is critical for growth and root development.
Xiangpei Kong, Huiyu Tian, Qianqian Yu, Feng Zhang, Rong Wang, Shan Gao, Wenhong Xu, Jiajia Liu, Eilon Shani, Chunxiang Fu, Gongke Zhou, Liangran Zhang, Xiansheng Zhang, Zhaojun Ding   +13 more
doaj   +1 more source

Extracellular Vesicles: A Mailcoach From Mast Cell to Other Cell Species

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Background Mast cells (MCs) are pivotal immune cells. Beyond soluble mediators, mast cell‐derived extracellular vesicles (MC‐EVs) are crucial for intercellular communication. MC‐EV heterogeneity, influenced by cellular activation and microenvironment, drives diverse biological roles.
Bingqi Zhang, Yueshan Sun, Tao Jiang, Runmin Long, Yuanbiao Guo   +4 more
wiley   +1 more source

Opposing function of mitochondrial prohibitin in aging

Aging, 2010
While specific signalling cascades involved in aging, such as the insulin/IGF-1 pathway, are well-described, the actual metabolic changes they elicit to prolong lifespan remain obscure. Nevertheless, the tuning of cellular metabolism towards maximal survival is the molecular basis of longevity.
Artal-Sanz, Marta, Tavernarakis, Nektarios   +1 more
openaire   +4 more sources