Results 91 to 100 of about 1,827 (179)

Prohibitins modulate viral infection.

, 2015
A. Western blot showing the detection of endogenous Phb1 and Phb2 proteins, as well as β-actin in L929 cells (Mock) transduced with the empty vector MK117 (vector) or with MK117 derivatives expressing shRNA directed against PHB1 (MK118) or against PHB2 ...
Didier Vertommen (417045), Thomas Michiels (76922), Laurent Gillet (31504), Marguerite Kreit (773288)   +3 more
core   +1 more source

Scalable discovery of homomeric protein–protein interactions from cross‐linking mass spectrometry data with CLAUDIO 2.0

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Cross‐linking mass spectrometry (XL‐MS) is a powerful biochemical approach for residue‐level characterization of protein structures and interactions under near‐native conditions. The growing scale of XL‐MS datasets demands scalable analysis pipelines that capture signals often overlooked in conventional workflows, including homomeric ...
Tobias Löser, Alexander Röhl, Markus Baier, Andrei Lupas, Oliver Kohlbacher, Hadeer Elhabashy   +5 more
wiley   +1 more source

Prohibitin 1 in liver injury and cancer

Experimental Biology and Medicine, 2020
Prohibitin 1 is an evolutionary conserved and ubiquitously expressed protein that exerts different biological functions depending on its subcellular localization. The role of prohibitin 1 in liver cancer is controversial as it can be pro- or anti-tumorigenic.
Lucía Barbier-Torres, Shelly C Lu
openaire   +5 more sources

Targeting prohibitins induces apoptosis in acute myeloid leukemia cells [PDF]

, 2019
Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins (PHBs). In this study, the pro-apoptotic effect of fluorizoline was assessed in two cell lines and 21 primary samples from patients with debut of acute ...
Moncunill Massaguer, Cristina, Arnan, Montserrat, Albericio Palomera, Fernando, Pons i Irazazábal, Gabriel, Lavilla Grífols, Rodolfo, Saura-Esteller, José, Gil i Santano, Joan, Cosialls Castel, Ana Mª, Pomares, Helena, Iglesias i Serret, Daniel, Palmeri, Claudia Mariela, Núñez-Vázquez, Sonia, Gamundi, Enric, González Barca, Eva, Preciado Gallego, Sara   +14 more
core   +1 more source

Resonant Recognition Model Study for Interactions between SARS CoV 2 and Human Proteins

Revista Cubana de Informática Médica, 2020
Este estudio se dedicó al análisis mediante el  Modelo de Reconocimiento Resonante (RRM) de las proteínas del SARS-CoV-2 y su posible interacción con otras proteínas humanas, específicamente, fueron analizadas las replicasas de SARS CoV y las ...
Susana Margarita Montesino Castillo, Cristóbal Yera Gálvez, José Luis Hernández Cáceres   +2 more
doaj  

SARS‐CoV‐2 and Cancer Biology: Exploring the Mechanistic Links

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Five years after the emergence of SARS‐CoV‐2 and the declaration of the COVID‐19 pandemic, the long‐term implications of COVID‐19 for cancer biology remain incompletely understood. Beyond the major disruptions in cancer screening, diagnosis, and treatment observed worldwide, increasing attention has focused on whether SARS‐CoV‐2 ...
Andrea Orue, Alejandro Cornejo, Héctor Rafael Rangel   +2 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Opposing function of mitochondrial prohibitin in aging

Aging, 2010
While specific signalling cascades involved in aging, such as the insulin/IGF-1 pathway, are well-described, the actual metabolic changes they elicit to prolong lifespan remain obscure. Nevertheless, the tuning of cellular metabolism towards maximal survival is the molecular basis of longevity.
Artal-Sanz, Marta, Tavernarakis, Nektarios   +1 more
openaire   +4 more sources

Evolution of prokaryotic SPFH proteins. [PDF]

, 2009
BACKGROUND: The SPFH protein superfamily is a diverse family of proteins whose eukaryotic members are involved in the scaffolding of detergent-resistant microdomains. Recently the origin of the SPFH proteins has been questioned.
Reuter Alexander, Markus Hinderhofer, Möller, Heiko M., Möller Heiko M, Hinderhofer Markus, Hinderhofer, Markus, Heiko M Möller, Walker, Christina A, Walker Christina A, Christina A Walker, Stuermer, Claudia AO, Friemel, Anke, Möller, Heiko M, Claudia AO Stuermer, Walker, Christina A., Alexander Reuter, Friemel Anke, Reuter, Alexander, Anke Friemel, Claudia AO Sturmer, Stuermer Claudia AO, Stürmer, Claudia   +21 more
core   +1 more source

Mass spectrometry proteomics for studying mitostasis

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Maintaining mitochondrial integrity and function is fundamental to cellular homeostasis. Cells rely on coordinated protein quality control (QC) systems—including intricate chaperone‐protease networks, the ubiquitin‐proteasome system, and cytosolic surveillance pathways—that together form a dynamic, cell‐wide mitostasis network governing the ...
Lakshita Sharma, Sristi Chakroborty, Hirak Das, Silke Oeljeklaus, Julian Bender, Bettina Warscheid   +5 more
wiley   +1 more source