Results 71 to 80 of about 1,728 (183)
Prohibitin as an oxidative stress biomarker in the eye [PDF]
International Journal of Biological Macromolecules, 2010 Identification of biomarker proteins in the retina and retinal pigment epithelium (RPE) under oxidative stress may imply new insights into signaling mechanisms of retinal degeneration at the molecular level. Proteomic data from an in vivo mice model in constant light and an in vitro oxidative stress model are compared to controls under normal ...
Hyunju, Lee +10 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 26, 8 May 2026.ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy +8 more
wiley +1 more source
Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans. [PDF]
PLoS ONE, 2014 Lifespan regulation by mitochondrial proteins has been well described, however, the mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins profoundly affecting ageing are prohibitins (PHB-1 and PHB-2).
Roxani Gatsi +5 more
doaj +1 more source
MedComm, Volume 7, Issue 5, May 2026.SalB binds to the C‐terminal of PHB1/2 heterodimer, inducing a conformational change that enhances Raf‐ERK pathway activation via Akt‐mediated phosphorylation, thereby promoting cardiomyocyte mitosis. ABSTRACT Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic ...
Ce Cao +10 more
wiley +1 more source
iScience, 2019 Summary: The coiled-coil motif mediates subunit oligomerization and scaffolding and underlies several fundamental biologic processes. Prohibitins (PHBs), mitochondrial inner membrane proteins involved in mitochondrial homeostasis and signal transduction,
Takahiro Yoshinaka +7 more
doaj +1 more source
Proteolytic control of mitochondrial protein translocases
Protein Science, Volume 35, Issue 5, May 2026.Abstract Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is continuously remodeled to meet changing cellular and environmental demands.
Lara Kroczek, Thomas Langer
wiley +1 more source
Quality control of protein import into mammalian mitochondria
Protein Science, Volume 35, Issue 5, May 2026.Abstract Mitochondrial function depends on the continuous import of hundreds of nuclear‐encoded proteins. Targeting and translocation of mitochondrial proteins is a multistep process that is inherently vulnerable to defects in cytosolic quality control systems as well as perturbations in mitochondrial protein import machinery and organelle function ...
Madeleine Goldstein +2 more
wiley +1 more source
Formation of Membrane-bound Ring Complexes by Prohibitins in Mitochondria
, 2004 Prohibitins comprise a remarkably conserved protein family in eukaryotic cells with proposed functions in cell cycle progression, senescence, apoptosis, and the regulation of mitochondrial activities.
Model, K. +5 more
core +1 more source
Structural Biology of Prohibitins and Annexin B1 [PDF]
, 2009 This thesis deals with the structural biology of two integral membrane proteins, prohibitin1 and prohibitin 2, and the membrane-associated protein Annexin B1.
Winter, Anja
core
Characterisation of detergent-insoluble membranes in pollen tubes of Nicotiana tabacum (L.)
Biology Open, 2015 Pollen tubes are the vehicle for sperm cell delivery to the embryo sac during fertilisation of Angiosperms. They provide an intriguing model for unravelling mechanisms of growing to extremes.
Alessandra Moscatelli +9 more
doaj +1 more source