Results 51 to 60 of about 1,728 (183)
Prohibitin, an antiproliferative protein, is localized to mitochondria
FEBS Letters, 1995 Prohibitin is a ubiquitously expressed protein with antiproliferative properties. When rat prohibitin tagged with a carboxy‐terminal c‐Myc epitope was expressed in baby hamster kidney cells the protein was targeted to mitochondria. In immunofluorescence microscopy prohibitin colocalized with a mitochondrial marker E3. Immunoelectron microscopy revealed
Ikonen, E +3 more
openaire +5 more sources
Role of ERLINs in the Control of Cell Fate through Lipid Rafts
Cells, 2021 ER lipid raft-associated protein 1 (ERLIN1) and 2 (ERLIN2) are 40 kDa transmembrane glycoproteins belonging to the family of prohibitins, containing a PHB domain.
Valeria Manganelli +9 more
doaj +1 more source
Prohibitin-1 Transgenic Mice Revealed an Important Role of Prohibitin in Testicular Steroidogenesis
Journal of the Endocrine Society, 2021 Abstract Testosterone, the male sex hormone, plays an important role in the sexual development and fertility. Consequently, its deficiency causes infertility, obesity, osteoporosis and cardiovascular diseases. Leydig cells (LCs) are the testicular interstitial cells responsible for the biosynthesis of testosterone in response to ...
Bassi, Geetika, Mishra, Suresh
openaire +1 more source
Flavaglines Stimulate Transient Receptor Potential Melastatin Type 6 (TRPM6) Channel Activity. [PDF]
PLoS ONE, 2015 Magnesium (Mg2+) is essential for enzymatic activity, brain function and muscle contraction. Blood Mg2+ concentrations are tightly regulated between 0.7 and 1.1 mM by Mg2+ (re)absorption in kidney and intestine.
Maxime G Blanchard +8 more
doaj +1 more source
Frontiers in Plant Science, 2021 Despite its central role as the ark of genetic information and gene expression the plant nucleus is surprisingly understudied. We isolated nuclei from the Arabidopsis thaliana dark grown cell culture left untreated and treated with flg22 and nlp20, two ...
Mohamed Ayash +6 more
doaj +1 more source
A Repressive Role for Prohibitin in Estrogen Signaling [PDF]
Molecular Endocrinology, 2008 Nuclear receptor-mediated gene expression is regulated by corepressors and coactivators. In this study we demonstrate that prohibitin (PHB), a potential tumor suppressor, functions as a potent transcriptional corepressor for estrogen receptor alpha (ERalpha).
Bin, He +7 more
openaire +2 more sources
CRISPR-Cas9-mediated protein tagging in human cells for RESOLFT nanoscopy and the analysis of mitochondrial prohibitins [PDF]
, 2015 Ectopic overexpression of fluorescent fusion proteins for live cell imaging studies often leads to a multitude of artefacts, but protein expression at endogenous levels in mammalian cells was difficult to achieve so far.
Ratz, M., Ratz, Michael
core +1 more source
Structure-function analysis of human stomatin: A mutation study. [PDF]
PLoS ONE, 2017 Stomatin is an ancient, widely expressed, oligomeric, monotopic membrane protein that is associated with cholesterol-rich membranes/lipid rafts. It is part of the SPFH superfamily including stomatin-like proteins, prohibitins, flotillin/reggie proteins ...
Stefanie Rungaldier +5 more
doaj +1 more source
Characterization and functional analysis of the proteins Prohibitin 1 and 2 in Trypanosoma cruzi.
PLoS Neglected Tropical Diseases, 2021 BackgroundChagas disease is the third most important neglected tropical disease. There is no vaccine available, and only two drugs are generally prescribed for the treatment, both of which with a wide range of side effects. Our study of T.
Ana K Ibarrola-Vannucci +8 more
doaj +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, EarlyView.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source