Results 51 to 60 of about 1,827 (179)
Development of prohibitin ligands against osteoporosis
European Journal of Medicinal Chemistry, 2021 Current therapeutic approaches to osteoporosis display some potential adverse effects and a limited efficacy on non-vertebral fracture reduction. Some sulfonylamidines targeting the scaffold proteins prohibitins-1 and 2 (PHB1/2) have been showed to inhibit the formation of osteoclasts in charge of bone resorption. Herein, we report the development of a
Tabti, Redouane +6 more
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Structural Biology of Prohibitins and Annexin B1 [PDF]
, 2009 This thesis deals with the structural biology of two integral membrane proteins, prohibitin1 and prohibitin 2, and the membrane-associated protein Annexin B1.
Winter, Anja
core +3 more sources
Functional characterization of prohibitins by conditional inactivation in the mouse [PDF]
, 2008 Prohibitins comprise an evolutionary conserved and ubiquitously expressed family of membrane proteins implicated in a large variety of cellular processes. Large assemblies of PHB1 and PHB2 subunits are localized in the inner membrane of mitochondria, but
Merkwirth, Carsten
core +1 more source
The Identification of Prohibitin in the Rat Heart Mitochondria in Heart Failure
Biomedicines, 2021 Mitochondria are considered the main organelles in the cell. They play an important role in both normal and abnormal heart function. There is a supramolecular organization between the complexes of the respiratory chain (supercomplexes (SCs)), which are ...
Yulia Baburina +5 more
doaj +1 more source
Exploring thylakoid emergence: evolution of membrane biogenesis and photosystem II assembly in early-diverging cyanobacteria. [PDF]
New PhytolOverview of the results. Phylogenetic analyses of 36 assembly factors of photosystem II (PSII) and 13 proteins involved in membrane dynamics summarized in Siebenaller & Schneider (2023) were performed to investigate the taxonomic distributions and structural differences between the thylakoid‐less Gloeobacterales and the Phycobacteria. Summary Thylakoid
Hambücken L, Baurain D, Cornet L.
europepmc +2 more sources
Downregulation of lung mitochondrial prohibitin in COPD [PDF]
Respiratory Medicine, 2012 Prohibitins (PHB1 and PHB2) are versatile proteins located at the inner mitochondrial membrane, maintaining normal mitochondrial function and morphology. They interact with the NADH dehydrogenase protein complex, which is essential for oxidoreductase activity within cells. However, their expression in lung epithelium, especially in smokers and patients
Soulitzis, Nikolaos +6 more
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Prohibitin-1 Transgenic Mice Revealed an Important Role of Prohibitin in Testicular Steroidogenesis
Journal of the Endocrine Society, 2021 Abstract Testosterone, the male sex hormone, plays an important role in the sexual development and fertility. Consequently, its deficiency causes infertility, obesity, osteoporosis and cardiovascular diseases. Leydig cells (LCs) are the testicular interstitial cells responsible for the biosynthesis of testosterone in response to ...
Bassi, Geetika, Mishra, Suresh
openaire +1 more source
Mitochondrial Band-7 family proteins: scaffolds for respiratory chain assembly?
Frontiers in Plant Science, 2014 The band-7 protein family comprises a diverse set of membrane-bound proteins characterised by the presence of a conserved domain. The exact function of this band-7 domain remains elusive, but examples from animal and bacterial stomatin-type proteins ...
Bernadette eGehl, Lee James Sweetlove
doaj +1 more source
Characterization of the genetic interactome of prohibitins in S. cerevisiae [PDF]
, 2009 Prohibitins comprise an evolutionary conserved and ubiquitously expressed family of membrane proteins that is essential for development in higher eukaryotes.
Osman, Christof
core +1 more source
Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells. [PDF]
PLoS ONE, 2012 Increase in mitochondrial biogenesis has been shown to accompany brown and white adipose cell differentiation. Prohibitins (PHBs), comprised of two evolutionarily conserved proteins, prohibitin-1 (PHB1) and prohibitin-2 (PHB2), are present in a high ...
Dong Liu +9 more
doaj +1 more source