Results 1 to 10 of about 583 (139)
Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer
Cells, 2023 Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Xiangbing Meng, Shujie Yang
exaly +6 more sources
Virulence, 2022 The vegetative insecticidal proteins (Vip3A) secreted by some Bacillus thuringiensis (Bt) strains during vegetative growth are regarded as a new generation of insecticidal toxins. Like insecticidal crystal proteins, they are also used in transgenic crops
Jun Cai
exaly +6 more sources
Redox Biology, 2023 Background: Doxorubicin (DOX) is among the most widely employed antitumor agents, although its clinical applications have been largely hindered by severe cardiotoxicity.
Yingmei Zhang, Jun Ren, Mingjie Yang
exaly +4 more sources
PRKN regulates inner mitochondrial membrane PHB2 during mitophagy
Autophagy Reports, 2023 PINK1 (PTEN induced kinase 1) and PRKN-mediated mitophagy is an important mitochondrial quality control pathway which selectively degrades damaged mitochondria and is tightly associated with neurodegenerative diseases, including Parkinson disease and ...
Shan Sun +6 more
doaj +4 more sources
Role of PHB2 as a potential biomarker in pan-cancer: a multi-database analysis
Scientific ReportsProhibitin2 (PHB2) is a mitochondrial endosomal protein that is closely linked to tumors; however, its specific molecular role remains unclear. Therefore, this study investigates the role of PHB2 in cancer.
Jingxin Zhang
exaly +4 more sources
Research, 2022 Disruption of the mitochondrial quality surveillance (MQS) system contributes to mitochondrial dysfunction in diabetic cardiomyopathy (DCM). In this study, we observed that cardiac expression of phosphoglycerate mutase 5 (PGAM5), a mitochondrial Ser/Thr ...
Rongjun Zou +10 more
doaj +4 more sources
Cell Death and Disease, 2023 The alteration of cellular energy metabolism is a hallmark of colorectal cancer (CRC). Accumulating evidence has suggested oxidative phosphorylation (OXPHOS) is upregulated to meet the demand for energy in tumor initiation and development.
Lin Ren +7 more
doaj +4 more sources
BIG3 Inhibits the Estrogen-Dependent Nuclear Translocation of PHB2 via Multiple Karyopherin-Alpha Proteins in Breast Cancer Cells. [PDF]
PLoS ONE, 2015 We recently reported that brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3) binds Prohibitin 2 (PHB2) in cytoplasm, thereby causing a loss of function of the PHB2 tumor suppressor in the nuclei of breast cancer cells.
Nam-Hee Kim +9 more
doaj +4 more sources
MedComm, 2023 Staphylococcus aureus (SA) is a major cause of sepsis, leading to acute lung injury (ALI) characterized by inflammation and oxidative stress. However, the role of the Nrf2/PHB2 pathway in SA‐induced ALI (SA‐ALI) remains unclear.
Si‐Hao Jin +14 more
doaj +2 more sources
Journal of Experimental & Clinical Cancer ResearchBackground Prohibitin 2 (PHB2) exhibits opposite functions of promoting or inhibiting tumour across various cancer types. In this study, we aim to investigate its functions and underlying mechanisms in the context of gastric cancer (GC).
Liang Xu +10 more
doaj +2 more sources