Role of PHB2 as a potential biomarker in pan-cancer: a multi-database analysis. [PDF]
Sci RepProhibitin2 (PHB2) is a mitochondrial endosomal protein that is closely linked to tumors; however, its specific molecular role remains unclear. Therefore, this study investigates the role of PHB2 in cancer.
Zhang J.
europepmc +5 more sources
Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer
Cells, 2023 Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Xiangbing Meng, Shujie Yang
exaly +5 more sources
Virulence, 2022 The vegetative insecticidal proteins (Vip3A) secreted by some Bacillus thuringiensis (Bt) strains during vegetative growth are regarded as a new generation of insecticidal toxins. Like insecticidal crystal proteins, they are also used in transgenic crops
Jun Cai
exaly +5 more sources
PHB2 mitigates intervertebral disc degeneration by modulating mitophagy to inhibit necroptosis in nucleus pulposus cells. [PDF]
iScienceSummary: Intervertebral disc degeneration involves loss of nucleus pulposus (NP) cells driven by inflammatory and mitochondrial stress-related death pathways.
Zhu Z +6 more
europepmc +4 more sources
PHB1 and PHB2 positively regulate IFN-β production by targeting MAVS in ducks. [PDF]
Poult SciPHB1 and PHB2, two subunits of the mitochondrial prohibitin complex, are critical regulators of antiviral innate immunity. Ducks, as natural reservoirs for RNA viruses, exhibit unique antiviral mechanisms. RIG-I is a key receptor for recognizing RNA viruses in ducks.
Liu J +5 more
europepmc +4 more sources
Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling. [PDF]
PLoS OneProhibitin 1 (PHB1) and prohibitin 2 (PHB2) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. They are ubiquitously expressed and implicated in the regulation of cell proliferation, migration,
Li M +9 more
europepmc +4 more sources
Redox Biology, 2023 Background: Doxorubicin (DOX) is among the most widely employed antitumor agents, although its clinical applications have been largely hindered by severe cardiotoxicity.
Yingmei Zhang, Jun Ren, Mingjie Yang
exaly +3 more sources
The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3‐PHB2 complex formation [PDF]
Cancer Science, 2021 AbstractPrevious studies reported the critical role of the brefeldin A–inhibited guanine nucleotide exchange protein 3–prohibitin 2 (BIG3‐PHB2) complex in modulating estrogen signaling activation in breast cancer cells, yet its pathophysiological roles in osteosarcoma (OS) cells remain elusive.
Toyomasa Katagiri, Tetsuro Yoshimaru
exaly +6 more sources
Prohibitin 2 ameliorates cisplatin-induced acute kidney injury by modulating mitochondrial homeostasis. [PDF]
Front PhysiolAcute kidney injury (AKI), associated with a major health burden globally, is frequently caused by nephrotoxic agents, specifically cisplatin. Prohibitin (PHB) 2, a highly conserved mitochondrial protein localized at the inner mitochondrial membrane, is ...
Zhang Q, Shi X, Yao L, Zhou P, Ding W.
europepmc +2 more sources
A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease
Neural Regeneration Research, 2023 Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson's disease, but the regulatory mechanism remains elusive. Prohibitin-2 (PHB2) is a newly discovered autophagy receptor in the mitochondrial inner membrane, and ...
Yongjiang Zhang +6 more
doaj +3 more sources