Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2 [PDF]
Life Science Alliance, 2021 The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria.
Giulia Bertolin +6 more
doaj +6 more sources
Prohibitin 2 ameliorates cisplatin-induced acute kidney injury by modulating mitochondrial homeostasis [PDF]
Frontiers in PhysiologyAcute kidney injury (AKI), associated with a major health burden globally, is frequently caused by nephrotoxic agents, specifically cisplatin. Prohibitin (PHB) 2, a highly conserved mitochondrial protein localized at the inner mitochondrial membrane, is ...
Qi Zhang +4 more
doaj +5 more sources
Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis [PDF]
Nature CommunicationsThe spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding genes contributes to malignancy development in various tumors. However, precise coordinated mechanisms underlying this phenomenon in tumorigenesis remains incompletely
Tianyi Ding +10 more
doaj +4 more sources
Mycobacterial protein PE_PGRS30 induces macrophage apoptosis through prohibitin 2 mitochondrial function interference [PDF]
Frontiers in Microbiology, 2023 PE_PGRS30 belongs to the PE_PGRS protein family and is characterized by a conserved Pro-Glu (PE) domain and a typically polymorphic GC-rich sequence (PGRS) domain. PE_PGRS30 is a virulence factor of Mycobacterium tuberculosis that induces macrophage cell
Kazunori Matsumura +2 more
doaj +2 more sources
Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy [PDF]
Journal of Advanced ResearchIntroduction: Septic cardiomyopathy (SCM) is a complication of myocardial injury in patients with severe sepsis. Objectives: This study highlights the potential of Astragaloside IV(AS) in the treatment of septic cardiomyopathy and provides a reference ...
Junyan Wang +7 more
doaj +2 more sources
Prohibitin 2 is Involved in Parkin-Mediated Mitophagy in Urothelial Cells of Cattle Infected with Bovine Papillomavirus [PDF]
Pathogens, 2020 Prohibitin 2 (PHB2), an inner mitochondrial membrane (IMM) protein, has recently been identified as a novel receptor involved in parkin-mediated mitophagy.
Francesca De Falco +5 more
doaj +2 more sources
CRISPR-editing of the virus vector Aedes albopictus cell line C6/36, illustrated by prohibitin 2 gene knockout [PDF]
MethodsXAedes mosquitoes are important virus vectors. We provide a toolkit for CRISPR-Cas9-editing of difficult-to-knockdown gene previously shown to be refractory to siRNA silencing in mosquito cells, which is pivotal in understanding vector biology, vector ...
Shiu-Wan Chan
doaj +2 more sources
Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors [PDF]
npj VirusesJapanese encephalitis virus (JEV), an Orthoflavivirus transmitted by mosquitoes, can cause severe disease in humans, yet its interactions with mosquito vectors remain poorly understood.
Mazhar Hussain +5 more
doaj +2 more sources
Recent advances in pancreatic β-cell dysfunction in type 2 diabetes mellitus: Intracellular stress and dedifferentiation. [PDF]
J Diabetes InvestigJournal of Diabetes Investigation, Volume 17, Issue 8, Page 1254-1256, August 2026.
Kido N, Asahara SI.
europepmc +2 more sources
Scalable discovery of homomeric protein-protein interactions from cross-linking mass spectrometry data with CLAUDIO 2.0. [PDF]
Protein SciAbstract Cross‐linking mass spectrometry (XL‐MS) is a powerful biochemical approach for residue‐level characterization of protein structures and interactions under near‐native conditions. The growing scale of XL‐MS datasets demands scalable analysis pipelines that capture signals often overlooked in conventional workflows, including homomeric ...
Löser T +5 more
europepmc +2 more sources