Results 21 to 30 of about 24,430,487 (196)

IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2–mediated immunosuppression [PDF]

The Journal of Clinical Investigation
The persistent challenge of sepsis-related mortality underscores the necessity for deeper insights. Our multicenter, cross-age cohort study identified insulin-like growth factor binding protein 6 (IGFBP6) as a critical regulator in sepsis diagnosis ...
Kai Chen, Ying Hu, Xiaoyan Yu, Hong Tang, Yanting Ruan, Yue Li, Xun Gao, Qing Zhao, Hong Wang, Xuemei Zhang, David Paul Molloy, Yibing Yin, Dapeng Chen, Zhixin Song   +13 more
doaj   +2 more sources

Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria. [PDF]

PLoS ONE, 2014
BackgroundThe pluripotent state of embryonic stem (ES) cells is controlled by a network of specific transcription factors. Recent studies also suggested the significant contribution of mitochondria on the regulation of pluripotent stem cells.
Megumi Kowno, Kanako Watanabe-Susaki, Hisako Ishimine, Shinji Komazaki, Kei Enomoto, Yasuhiro Seki, Ying Ying Wang, Yohei Ishigaki, Naoto Ninomiya, Taka-aki K Noguchi, Yuko Kokubu, Keigoh Ohnishi, Yoshiro Nakajima, Kaoru Kato, Atsushi Intoh, Hitomi Takada, Norio Yamakawa, Pi-Chao Wang, Makoto Asashima, Akira Kurisaki   +19 more
doaj   +2 more sources

Identification of Prohibitin (PHB) as an Entry Factor of Highly Pathogenic Coronaviruses Using Metabolic Glycoengineering and Photo-Crosslinking Techniques [PDF]

Emerging Microbes and Infections
Coronaviruses (CoVs) rely on host surface factors to mediate viral attachment and entry, yet conserved host cofactors shared across different CoVs remain poorly defined.
Xingxing Zhu, Xiaoyang Wang, Yiming Wang, Xinchen Wang, Yuanhao Li, Liwen Hua, Honggao Duan, Rongding Yan, Tao Yuan, Jing Li, Yeshuang Yuan, Bo Zhang, Demin Zhou, Sulong Xiao   +13 more
doaj   +2 more sources

Involvement of prohibitin 1 and prohibitin 2 upregulation in cBSA-induced podocyte cytotoxicity. [PDF]

J Food Drug Anal, 2020
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, when not effectively treated. The aim of this study was to discover new targets for the diagnosis and treatment of MN. A reliable mouse model of MN was used by the administration of cationic bovine serum albumin (cBSA).
Wu HH, Chen CJ, Lin PY, Liu YH.
europepmc   +3 more sources

Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation. [PDF]

Mol Med Rep, 2021
Platelet mitophagy is a major pathway involved in the clearance of injured mitochondria during hemostasis and thrombosis. Prohibitin 2 (PHB2) has recently emerged as an inner mitochondrial membrane receptor involved in mitophagy. However, the mechanisms underlying PHB2‑mediated platelet mitophagy and activation are not completely understood.
Hu LL, Zou K, Chen Y, Wu LJ, Cao J, Xiong XY, Wang L, Cheng XS, Xiao QZ, Yang RQ.   +9 more
europepmc   +5 more sources

Bif-1 Interacts with Prohibitin-2 to Regulate Mitochondrial Inner Membrane during Cell Stress and Apoptosis. [PDF]

J Am Soc Nephrol, 2019
Background Mitochondria are dynamic organelles that undergo fission and fusion. During cell stress, mitochondrial dynamics shift to fission, leading to mitochondrial fragmentation, membrane leakage, and apoptosis.
Cho SG, Xiao X, Wang S, Gao H, Rafikov R, Black S, Huang S, Ding HF, Yoon Y, Kirken RA, Yin XM, Wang HG, Dong Z.   +12 more
europepmc   +2 more sources

PHB2/prohibitin 2: An inner membrane mitophagy receptor. [PDF]

Cell Res, 2017
Mitophagy, the selective autophagic elimination of mitochondria, is a conserved cellular process critical for maintaining normal cellular physiology, and defects in this process are associated with certain pathophysiologies. In a recently published paper, Wei et al. describe their discovery of a hitherto unexplored mechanism of marking mitochondria for
Lahiri V, Klionsky DJ.
europepmc   +4 more sources

Dihydromyricetin induces mitophagy by regulating Prohibitin 2 pathway in vascular endothelial cells

Di-san junyi daxue xuebao, 2022
Objective To observe the effects of dihydromyricetin on mitophagy in vascular endothelial cells, and to clarify the underlying role of Prohibitin 2 in the process.
HU Qin, SHEN Hui, ZHANG Ting, LI Yafei
doaj   +1 more source

COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity. [PDF]

Cell Death Dis, 2018
Vascular smooth muscle cells (VSMCs) are highly phenotypically plastic, and loss of the contractile phenotype in VSMCs has been recognized at the early onset of the pathology of a variety of vascular diseases. However, the endogenous regulatory mechanism
Jia Y, Wang M, Mao C, Yu F, Wang Y, Xiao R, Jiang C, Zheng L, Xu Q, Zheng M, Fu Y, Hu Q, Kong W.   +12 more
europepmc   +2 more sources

CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription. [PDF]

Cell Signal, 2011
Prohibitin 2 (PHB2) is an evolutionarily conserved and ubiquitously expressed multifunctional protein which is present in various cellular compartments including the nucleus. However, mechanisms underlying various functions of PHB2 are not fully explored yet.
Sun L, Cao X, Liu B, Huang H, Wang X, Sui L, Yin W, Ma K.   +7 more
europepmc   +3 more sources