Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor [PDF]
Cell, 2017 The removal of unwanted or damaged mitochondria by autophagy, a process called mitophagy, is essential for key events in development, cellular homeostasis, tumor suppression, and prevention of neurodegeneration and aging. However, the precise mechanisms of mitophagy remain uncertain.
Beth Levine +2 more
exaly +5 more sources
The Role of Prohibitin-2 in Diseases
Frontiers in Bioscience-Landmark, 2023 Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis.
Fang Liu +3 more
doaj +3 more sources
Prohibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegans. [PDF]
PLoS ONE, 2014 Lifespan regulation by mitochondrial proteins has been well described, however, the mechanism of this regulation is not fully understood. Amongst the mitochondrial proteins profoundly affecting ageing are prohibitins (PHB-1 and PHB-2).
Roxani Gatsi +5 more
doaj +2 more sources
Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells [PDF]
Nature Communications, 2021 Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and ...
Gustavo Della-Flora Nunes +10 more
doaj +2 more sources
An Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential [PDF]
Cell Reports, 2018 Summary: Proteins of the stomatin/prohibitin/flotillin/HfIK/C (SPFH) family are membrane-anchored and perform diverse cellular functions in different organelles.
Joachim Michael Matz +3 more
doaj +3 more sources
Characterization and functional analysis of the proteins Prohibitin 1 and 2 in Trypanosoma cruzi.
PLoS Neglected Tropical Diseases, 2021 BackgroundChagas disease is the third most important neglected tropical disease. There is no vaccine available, and only two drugs are generally prescribed for the treatment, both of which with a wide range of side effects. Our study of T.
Ana K Ibarrola-Vannucci +8 more
doaj +7 more sources
Immunohistochemical activity of Prohibitin-2 and Stomatin-Like Protein-2 in patients with ulcerative colitis [PDF]
The Turkish Journal of Gastroenterology, 2016 Background/Aims: We aimed to semi-quantitatively investigate prohibitin-2 (Phb-2) and stomatin-like protein-2 (Slp-2) expressions in patients with ulcerative colitis (UC) and healthy controls using the immunohistochemical (IHC) method.
İrfan Küçük +9 more
doaj +6 more sources
Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids [PDF]
Frontiers in ImmunologyBackground and aimsIgG4-related cholangitis (IRC) is the hepatobiliary manifestation of IgG4-related disease, a systemic B cell-driven fibro-inflammatory disorder.
Remco Kersten +6 more
doaj +2 more sources
The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells [PDF]
Oncogenesis, 2021 Fluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells from hematologic malignancies by inducing the integrated stress response and ER stress. Recently, it was
Sonia Núñez-Vázquez +9 more
doaj +2 more sources
Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.
PLoS ONE, 2012 Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya +5 more
doaj +7 more sources