Results 31 to 40 of about 24,430,487 (196)

Essential Protein PHB2 and Its Regulatory Mechanisms in Cancer

Cells, 2023
Prohibitins (PHBs) are a highly conserved class of proteins and have an essential role in transcription, epigenetic regulation, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism.
Amanda Qi, Lillie Lamont, Evelyn Liu, Sarina D. Murray, Xiangbing Meng, Shujie Yang   +5 more
doaj   +1 more source

Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure. [PDF]

Cell Death Dis, 2020
AbstractFatty acids are the most major substrate source for adult cardiac energy generation. Prohibitin 2 (PHB2), a highly conserved protein located in mitochondrial inner membrane, plays key roles in cellular energy metabolic homeostasis. However, its functions in regulating cardiac fatty acid metabolism have remained largely unknown.
Wu D, Jian C, Peng Q, Hou T, Wu K, Shang B, Zhao M, Wang Y, Zheng W, Ma Q, Li CY, Cheng H, Wang X, Zhao L.   +13 more
europepmc   +4 more sources

Nrf2/PHB2 alleviates mitochondrial damage and protects against Staphylococcus aureus‐induced acute lung injury

MedComm, 2023
Staphylococcus aureus (SA) is a major cause of sepsis, leading to acute lung injury (ALI) characterized by inflammation and oxidative stress. However, the role of the Nrf2/PHB2 pathway in SA‐induced ALI (SA‐ALI) remains unclear.
Si‐Hao Jin, Jiao‐Jiao Sun, Gang Liu, Li‐Juan Shen, Yuan Weng, Jin‐You Li, Min Chen, Ying‐Ying Wang, Zhi‐Qi Gao, Feng‐Juan Jiang, Sheng‐Peng Li, Dan Chen, Qing‐Feng Pang, Ya‐Xian Wu, Zhi‐Qiang Wang   +14 more
doaj   +1 more source

Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis

Advanced Science, 2022
Persistent uptake of high‐calorie diets induces the storage of excessive lipid in visceral adipose tissue. Lipids secreted from obese adipose tissue are accumulated in peripheral tissues such as the liver, pancreas, and muscle, and impair insulin ...
Juhyeong Hong, Yong‐Hee Kim
doaj   +1 more source

Functional Studies of Plasmodium falciparum’s Prohibitin1 and Prohibitin 2 in Yeast

Indian Journal of Medical Microbiology, 2020
Prohibitins (PHBs) are evolutionarily conserved mitochondrial integral membrane proteins, shown to regulate mitochondrial structure and function, and can be classified into PHB1 and PHB2. PHB1 and PHB2 have been shown to interact with each other, and form heterodimers in mitochondrial inner membrane.
Savitha, Chellappan, Subarna, Roy, Jyoti M, Nagmoti, Wahida, Tabassum, S L, Hoti, Mrinal Kanti, Bhattacharyya, Praveen Balabaskaran, Nina   +6 more
openaire   +2 more sources

Identification of the Cellular Prohibitin 1/Prohibitin 2 Heterodimer as an Interaction Partner of the C-Terminal Cytoplasmic Domain of the HIV-1 Glycoprotein [PDF]

Journal of Virology, 2010
ABSTRACTOur studies aim to elucidate the functions carried out by the very long, and in its length highly conserved, C-terminal cytoplasmic domain (Env-CT) of the HIV-1 glycoprotein. Mass spectrometric analysis of cellular proteins bound to a tagged version of the HIV Env-CT led to the identification of the prohibitin 1 and 2 proteins (Phb1 and Phb2 ...
Vanessa, Emerson, Denise, Holtkotte, Tanya, Pfeiffer, I-Hsuan, Wang, Martina, Schnölzer, Tore, Kempf, Valerie, Bosch   +6 more
openaire   +3 more sources

Proteomic analysis of the rat ovary following chronic low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [PDF]

, 2009
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine-disrupting chemical and reproductive toxicant. In order to elucidate low-dose TCDD-mediated effects on reproductive or endocrine functions, female Sprague-Dawley rats were
Chen, Xi, Chun-mei Zhang, Jing Liu, Ma, X.M., Zhang, C.M., Zhao, L.J., Zhang, Chun-mei, Chen, X., Li-jun Zhao, Sun, M., Ma, Xiao-ming, Coenraads, P.J., Tang, N.J., Liu, J., Tang, Nai-jun, Liu, Jing, Zhao, Li-jun, Xi Chen, Pieter-Jan Coenraads, Ma, S.W., Shi-wei Ma, Min Sun, Coenraads, Pieter-Jan, Xiao-ming Ma, Sun, Min, Ma, Shi-wei, Nai-jun Tang   +26 more
core   +2 more sources

Interaction between PHB2 and Enterovirus A71 VP1 Induces Autophagy and Affects EV-A71 Infection

Viruses, 2020
Enterovirus A71 (EV-A71) is a major pathogen that causes severe and fatal cases of hand-foot-and-mouth disease (HFMD). HFMD caused by EV-A71 seriously endangers children’s health.
Weitao Su, Shan Huang, Huimin Zhu, Bao Zhang, Xianbo Wu   +4 more
doaj   +1 more source

Prohibitins are required for cancer cell proliferation and adhesion.

PLoS ONE, 2010
Prohibitin 1 (PHB1) is a highly conserved protein that together with its homologue prohibitin 2 (PHB2) mainly localizes to the inner mitochondrial membrane.
Claudia Sievers, Gwendolyn Billig, Kathleen Gottschalk, Thomas Rudel   +3 more
doaj   +1 more source

Knockdown of prohibitin 2 promotes apoptosis in non-small cell lung cancer cell line A549 [PDF]

Jichu yixue yu linchuang, 2023
Objective To explore mechanism of prohibitin 2(PHB2) inhibition on the apoptosis of non-small cell lung cancer cell line A549. Methods For stable knockdown of PHB2, A549 strain was infected with lentiviruses. A549 cells with PHB2 depletion were
ZHANG Jing, YANG Zigeng, WEI Hongmei, NING Haihong, XUE Xixi, JIN Ling, WU Bin
doaj   +1 more source