Results 11 to 20 of about 583 (139)

The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3‐PHB2 complex formation [PDF]

Cancer Science, 2021
Previous studies reported the critical role of the brefeldin A–inhibited guanine nucleotide exchange protein 3–prohibitin 2 (BIG3-PHB2) complex in modulating estrogen signaling activation in breast cancer cells, yet its pathophysiological roles in ...
Toyomasa Katagiri, Tetsuro Yoshimaru
exaly   +8 more sources

Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling.

PLoS ONE
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are highly conserved proteins belonging to the stomatin-prohibitin flotillin-HflC/K (SPFH) protein superfamily. They are ubiquitously expressed and implicated in the regulation of cell proliferation, migration,
Mei Li, Xiaoyan Hu, Xinxin Hu, Fuhua Gao, Ying Cui, Xiaoqing Wei, Yuanhua Qin, Xiaohua An, Ying Zhao, Ying Gao   +9 more
doaj   +4 more sources

PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE–RAGE pathway

Open Life Sciences
Fibrosis is the primary cause of retinal detachment and visual decline. Here, we investigated the role of Prohibitin 2 (PHB2) in modulating fibrosis in ARPE-19 cells stimulated by transforming growth factor (TGF)-β2.
Xiaoxiao Cai
exaly   +4 more sources

PHB2 Protects Sister-Chromatid Cohesion in Mitosis [PDF]

Current Biology, 2007
SummaryCohesion between sister chromatids is essential for proper chromosome segregation in mitosis. In vertebrate mitotic cells, most cohesin is removed from the chromosome arms [1–4], but centromeric cohesin is protected by shugoshin until the onset of
Akihiro Morimoto, Hideaki Takata, Masatoshi Nakagawa, Morimoto, Akihiro, Kiichi Fukui, Azuma, Takachika, Ono-Maniwa, Rika, Rika Ono-Maniwa, Takata, Hideaki, Kurihara, Daisuke, Susumu Uchiyama, Matsunaga, Sachihiro, Fukui, Kiichi, Takachika Azuma, Ma, Nan, Daisuke Kurihara, Nan Ma, Nakagawa, Masatoshi, Uchiyama, Susumu, Sachihiro Matsunaga   +19 more
core   +4 more sources

Oxidative stress suppresses PHB2‐mediated mitophagy in β‐cells via the Nrf2/PHB2 pathway

Journal of Diabetes Investigation
Aims/Introduction Mitochondrial damage caused by oxidative stress is a main driver of pancreatic β‐cell dysfunction in the pathogenesis of type 2 diabetes mellitus.
Shan Liu, Rui Zhang, Lan Zhang, Aige Yang, Yuqing Guo, Lei Jiang, Huijuan Wang, Shunjiang Xu, Huimin Zhou   +8 more
doaj   +3 more sources

Non-classical ferroptosis inhibition by a small molecule targeting PHB2

Nature Communications, 2022
Ferroptosis is a new type of programmed cell death characterized by iron-dependent lipid peroxidation. Ferroptosis inhibition is thought as a promising therapeutic strategy for a variety of diseases.
Dai, Lunzhi, Mu, Bo, Li, Linli, Désaubry, Laurent, Zhang, Liting, You, Jing, Tian, Chenyu, Yang, Shengyong, Yang, Wei, Bin, Huachao, Xu, Zhiqiang, Ma, Ronggang, Wu, Ming, Zhang, Guo, Shao, Zhenhua, Huang, Chong   +15 more
core   +5 more sources

Expression of PHB2 in Rat Brain Cortex Following Traumatic Brain Injury [PDF]

International Journal of Molecular Sciences, 2014
Prohibitin2 (PHB2) is a ubiquitous, evolutionarily strongly conserved protein. It is one of the components of the prohibitin complex, which comprises two highly homologous subunits, PHB1 and PHB2.
Ying Yue, Xinjuan Fan, Weijie Chen, Xingxing Gu, Ting Xu, Yuanyuan Tan   +5 more
core   +3 more sources

A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease

Neural Regeneration Research, 2023
Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson's disease, but the regulatory mechanism remains elusive. Prohibitin-2 (PHB2) is a newly discovered autophagy receptor in the mitochondrial inner membrane, and ...
Yongjiang Zhang, Shiyi Yin, Run Song, Xiaoyi Lai, Mengmeng Shen, Jiannan Wu, Junqiang Yan   +6 more
doaj   +3 more sources

Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling

Antioxidants, 2023
Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under cardiac stress remains poorly understood.
Kaina Zhang, Yeqing Zheng, Gaowa Bao, Wenzhuo Ma, Bing Han, Hongwen Shi, Zhenghang Zhao   +6 more
doaj   +2 more sources

Efficient PHB2 (prohibitin 2) exposure during mitophagy depends on VDAC1 (voltage dependent anion channel 1)

Autophagy
Exposure of inner mitochondrial membrane resident protein PHB2 (prohibitin 2) during autophagic removal of depolarized mitochondria (mitophagy) depends on the ubiquitin-proteasome system. This uncovering facilitates the PHB2 interaction with phagophore
Elena Marchesan, Federico Caicci, Elena Ziviani   +2 more
exaly   +2 more sources