Results 11 to 20 of about 2,921 (152)

Oxidative stress suppresses PHB2‐mediated mitophagy in β‐cells via the Nrf2/PHB2 pathway

Journal of Diabetes Investigation
Aims/Introduction Mitochondrial damage caused by oxidative stress is a main driver of pancreatic β‐cell dysfunction in the pathogenesis of type 2 diabetes mellitus.
Shan Liu, Rui Zhang, Lan Zhang, Aige Yang, Yuqing Guo, Lei Jiang, Huijuan Wang, Shunjiang Xu, Huimin Zhou   +8 more
doaj   +3 more sources

PRKN regulates inner mitochondrial membrane PHB2 during mitophagy

Autophagy Reports, 2023
PINK1 (PTEN induced kinase 1) and PRKN-mediated mitophagy is an important mitochondrial quality control pathway which selectively degrades damaged mitochondria and is tightly associated with neurodegenerative diseases, including Parkinson disease and ...
Shan Sun, Hongfeng Wang, Qilian Ma, Ningning Li, Mian Cao, Kin Yip Tam, Zheng Ying   +6 more
doaj   +3 more sources

Prohibitins: emerging host targets of bacteria and viruses at the plasma membrane, mitochondria, and cytoplasm. [PDF]

Microb Cell
Ubiquitously expressed Prohibitin-1 (PHB1) and Prohibitin-2 (PHB2) serve pleiotropic functions in cellular processes, including signal transduction, mitochondrial metabolism and dynamics, and lipid raft formation. Located in phospholipid-rich subcellular
Rivera-Palomino GO, Theiss AL.
europepmc   +2 more sources

Src-mediated PHB2 phosphorylation disrupts mitochondrial cristae through cardiolipin dissociation in hepatocellular carcinoma. [PDF]

Redox Biol
Hepatocellular carcinoma (HCC) displays mitochondrial dysfunction characterized by disrupted redox homeostasis and cristae disorganization, yet the underlying molecular mechanisms are unclear.
Shao Z, Yang X, Wang B, Wang X, Zhao D, Liu B, Nan J.   +6 more
europepmc   +2 more sources

Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells. [PDF]

Commun Biol
Aurora kinase A/AURKA is a serine/threonine kinase frequently overexpressed in cancer. Recent discoveries pointed to subcellular pools of AURKA, including at mitochondria.
Djehal A, Caron C, Giordano D, Pizza V, Farin K, Facchiano A, Désaubry L, Bertolin G.   +7 more
europepmc   +2 more sources

Lamprey PHB2 maintains mitochondrial stability by tanslocation to the mitochondria under oxidative stress

Fish and Shellfish Immunology, 2020
Before we have reported lamprey PHB2 could enhance the cellular oxidative-stressed tolerance, here the aim was to explore its mechanisms. We used flow cytometry analysis to identify a Lampetra morii homologue of PHB2 (Lm-PHB2) that could significantly decrease the levels of ROS generation in HEK293T cells. According to confocal microscopy observations,
Qingwei Li, Tiesong Li
exaly   +3 more sources

PGAM5-Mediated PHB2 Dephosphorylation Contributes to Diabetic Cardiomyopathy by Disrupting Mitochondrial Quality Surveillance

Research, 2022
Disruption of the mitochondrial quality surveillance (MQS) system contributes to mitochondrial dysfunction in diabetic cardiomyopathy (DCM). In this study, we observed that cardiac expression of phosphoglycerate mutase 5 (PGAM5), a mitochondrial Ser/Thr ...
Rongjun Zou, Jun Tao, Jie He, Chaojie Wang, Songtao Tan, Yu Xia, Xing Chang, Ruibing Li, Ge Wang, Hao Zhou, Xiaoping Fan   +10 more
doaj   +3 more sources

PHB2 ameliorates ferroptosis and aortic aneurysm/dissection through NEDD4L-dependent ubiquitination of NCOA4

Redox Biology
Background: Aortic aneurysm/dissection (AAD) is a catastrophic vascular emergency with limited therapeutic options and poorly understood molecular underpinnings.
Shengjun Xiong, Jie Lin, Ying An, Yuxin Du, Yiran E. Li, Zunhui Du, Rongjun Zou, Miyesaier Abudureyimu, Junbo Ge, Yingmei Zhang, Jun Ren   +10 more
doaj   +3 more sources

PHB2 promotes colorectal cancer cell proliferation and tumorigenesis through NDUFS1-mediated oxidative phosphorylation

Cell Death and Disease, 2023
The alteration of cellular energy metabolism is a hallmark of colorectal cancer (CRC). Accumulating evidence has suggested oxidative phosphorylation (OXPHOS) is upregulated to meet the demand for energy in tumor initiation and development.
Lin Ren, Li Meng, Jing Gao, Mingdian Lu, Chengyu Guo, Yunyun Li, Ziye Rong, Yan Ye   +7 more
doaj   +3 more sources

Complement protein C1q induces endothelial apoptosis through C1qBP regulation of mitochondrial function in lung endothelial cells in systemic sclerosis. [PDF]

Mol Med
Background Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and fibrosis, with pulmonary complications as the leading cause of mortality.
Yi Z, Liu K, Shabin M.
europepmc   +2 more sources