Results 31 to 40 of about 2,921 (152)

LECT2-PHB2 axis: a new mechanistic insight and therapeutic opportunity in alcohol-associated hepatitis. [PDF]

Gut
Li H, Song M, Hylemon PB, Zhou H.
europepmc   +3 more sources

Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens [PDF]

Oncogene, 2004
Early diagnosis of cancer is crucial for successful treatment. Noninvasive assays for detecting tumor-derived antigens in serum and other bodily fluids have the potential to screen healthy individuals for hitherto undetected cancers. Very few such assays have been successfully developed, in part because identifying potential target antigens remains a ...
Mengwasser, J., Piau, A., Schlag, P., Sleeman, J. P.   +3 more
openaire   +3 more sources

Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2

Life Science Alliance, 2021
The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria.
Giulia Bertolin, Marie-Clotilde Alves-Guerra, Angélique Cheron, Agnès Burel, Claude Prigent, Roland Le Borgne, Marc Tramier   +6 more
doaj   +1 more source

Knockdown of prohibitin 2 promotes apoptosis in non-small cell lung cancer cell line A549 [PDF]

Jichu yixue yu linchuang, 2023
Objective To explore mechanism of prohibitin 2(PHB2) inhibition on the apoptosis of non-small cell lung cancer cell line A549. Methods For stable knockdown of PHB2, A549 strain was infected with lentiviruses. A549 cells with PHB2 depletion were
ZHANG Jing, YANG Zigeng, WEI Hongmei, NING Haihong, XUE Xixi, JIN Ling, WU Bin
doaj   +1 more source

Expression of PHB2 in Rat Brain Cortex Following Traumatic Brain Injury [PDF]

International Journal of Molecular Sciences, 2014
Prohibitin2 (PHB2) is a ubiquitous, evolutionarily strongly conserved protein. It is one of the components of the prohibitin complex, which comprises two highly homologous subunits, PHB1 and PHB2. PHB2 is present in various cellular compartments including the nucleus and mitochondria.
Xu, Ting, Fan, Xinjuan, Tan, Yuanyuan, Yue, Ying, Chen, Weijie, Gu, Xingxing   +5 more
openaire   +2 more sources

Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling

Antioxidants, 2023
Recent studies have shown that FMS-like receptor tyrosine kinase 3 (Flt3) has a beneficial effect on cardiac maladaptive remodeling. However, the role and mechanism of Flt3 in mitochondrial dynamic imbalance under cardiac stress remains poorly understood.
Kaina Zhang, Yeqing Zheng, Gaowa Bao, Wenzhuo Ma, Bing Han, Hongwen Shi, Zhenghang Zhao   +6 more
doaj   +1 more source

PHB2 promotes tumorigenesis via RACK1 in non-small cell lung cancer

Theranostics, 2021
Background: Lung cancer has the highest mortality rate among cancers worldwide, with non-small cell lung cancer (NSCLC) the most common type. Increasing evidence shows that PHB2 is highly expressed in other cancer types; however, the effects of PHB2 in NSCLC are currently poorly understood.
Wu, Bin, Chang, Ning, Xi, Hangtian, Xiong, Jie, Zhou, Ying, Wu, Yingtong, Wu, Shuo, Wang, Ning, Yi, Hongyu, Song, Yun, Chen, Lihua, Zhang, Jian   +11 more
openaire   +2 more sources

Prohibitin 2 is Involved in Parkin-Mediated Mitophagy in Urothelial Cells of Cattle Infected with Bovine Papillomavirus

Pathogens, 2020
Prohibitin 2 (PHB2), an inner mitochondrial membrane (IMM) protein, has recently been identified as a novel receptor involved in parkin-mediated mitophagy.
Francesca De Falco, Ivan Gentile, Pellegrino Cerino, Anna Cutarelli, Cornel Catoi, Sante Roperto   +5 more
doaj   +1 more source

Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria.

PLoS ONE, 2014
BackgroundThe pluripotent state of embryonic stem (ES) cells is controlled by a network of specific transcription factors. Recent studies also suggested the significant contribution of mitochondria on the regulation of pluripotent stem cells.
Megumi Kowno, Kanako Watanabe-Susaki, Hisako Ishimine, Shinji Komazaki, Kei Enomoto, Yasuhiro Seki, Ying Ying Wang, Yohei Ishigaki, Naoto Ninomiya, Taka-aki K Noguchi, Yuko Kokubu, Keigoh Ohnishi, Yoshiro Nakajima, Kaoru Kato, Atsushi Intoh, Hitomi Takada, Norio Yamakawa, Pi-Chao Wang, Makoto Asashima, Akira Kurisaki   +19 more
doaj   +1 more source

Nrf2/PHB2 alleviates mitochondrial damage and protects against Staphylococcus aureus‐induced acute lung injury

MedComm, 2023
Staphylococcus aureus (SA) is a major cause of sepsis, leading to acute lung injury (ALI) characterized by inflammation and oxidative stress. However, the role of the Nrf2/PHB2 pathway in SA‐induced ALI (SA‐ALI) remains unclear.
Si‐Hao Jin, Jiao‐Jiao Sun, Gang Liu, Li‐Juan Shen, Yuan Weng, Jin‐You Li, Min Chen, Ying‐Ying Wang, Zhi‐Qi Gao, Feng‐Juan Jiang, Sheng‐Peng Li, Dan Chen, Qing‐Feng Pang, Ya‐Xian Wu, Zhi‐Qiang Wang   +14 more
doaj   +1 more source