Results 31 to 40 of about 583 (139)

PHB2/prohibitin 2: An inner membrane mitophagy receptor [PDF]

Cell Research, 2017
Mitophagy, the selective autophagic elimination of mitochondria, is a conserved cellular process critical for maintaining normal cellular physiology, and defects in this process are associated with certain pathophysiologies. In a recently published paper, Wei et al. describe their discovery of a hitherto unexplored mechanism of marking mitochondria for
Vikramjit, Lahiri, Daniel J, Klionsky
openaire   +2 more sources

Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2

Life Science Alliance, 2021
The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria.
Giulia Bertolin, Marie-Clotilde Alves-Guerra, Angélique Cheron, Agnès Burel, Claude Prigent, Roland Le Borgne, Marc Tramier   +6 more
doaj   +1 more source

Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens [PDF]

Oncogene, 2004
Early diagnosis of cancer is crucial for successful treatment. Noninvasive assays for detecting tumor-derived antigens in serum and other bodily fluids have the potential to screen healthy individuals for hitherto undetected cancers. Very few such assays have been successfully developed, in part because identifying potential target antigens remains a ...
Mengwasser, J., Piau, A., Schlag, P., Sleeman, J. P.   +3 more
openaire   +3 more sources

Knockdown of prohibitin 2 promotes apoptosis in non-small cell lung cancer cell line A549 [PDF]

Jichu yixue yu linchuang, 2023
Objective To explore mechanism of prohibitin 2(PHB2) inhibition on the apoptosis of non-small cell lung cancer cell line A549. Methods For stable knockdown of PHB2, A549 strain was infected with lentiviruses. A549 cells with PHB2 depletion were
ZHANG Jing, YANG Zigeng, WEI Hongmei, NING Haihong, XUE Xixi, JIN Ling, WU Bin
doaj   +1 more source

Prohibitin 2 is Involved in Parkin-Mediated Mitophagy in Urothelial Cells of Cattle Infected with Bovine Papillomavirus

Pathogens, 2020
Prohibitin 2 (PHB2), an inner mitochondrial membrane (IMM) protein, has recently been identified as a novel receptor involved in parkin-mediated mitophagy.
Francesca De Falco, Ivan Gentile, Pellegrino Cerino, Anna Cutarelli, Cornel Catoi, Sante Roperto   +5 more
doaj   +1 more source

PHB2 promotes tumorigenesis via RACK1 in non-small cell lung cancer

Theranostics, 2021
Background: Lung cancer has the highest mortality rate among cancers worldwide, with non-small cell lung cancer (NSCLC) the most common type. Increasing evidence shows that PHB2 is highly expressed in other cancer types; however, the effects of PHB2 in NSCLC are currently poorly understood.
Wu, Bin, Chang, Ning, Xi, Hangtian, Xiong, Jie, Zhou, Ying, Wu, Yingtong, Wu, Shuo, Wang, Ning, Yi, Hongyu, Song, Yun, Chen, Lihua, Zhang, Jian   +11 more
openaire   +2 more sources

Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria.

PLoS ONE, 2014
BackgroundThe pluripotent state of embryonic stem (ES) cells is controlled by a network of specific transcription factors. Recent studies also suggested the significant contribution of mitochondria on the regulation of pluripotent stem cells.
Megumi Kowno, Kanako Watanabe-Susaki, Hisako Ishimine, Shinji Komazaki, Kei Enomoto, Yasuhiro Seki, Ying Ying Wang, Yohei Ishigaki, Naoto Ninomiya, Taka-aki K Noguchi, Yuko Kokubu, Keigoh Ohnishi, Yoshiro Nakajima, Kaoru Kato, Atsushi Intoh, Hitomi Takada, Norio Yamakawa, Pi-Chao Wang, Makoto Asashima, Akira Kurisaki   +19 more
doaj   +1 more source

The Role of Prohibitin-2 in Diseases

Frontiers in Bioscience-Landmark, 2023
Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis.
Fang Liu, You Zhang, Zhiyong Guo, An-Jing Ren   +3 more
doaj   +1 more source

Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.

PLoS ONE, 2012
Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya, Aisha Hilliard, Louying Zhang, John M Asara, Louis J Ptáček, Ying-Hui Fu   +5 more
doaj   +1 more source

PHB2 Alleviates Neurotoxicity of Prion Peptide PrP106–126 via PINK1/Parkin-Dependent Mitophagy

, 2023
Prion diseases are a group of neurodegenerative diseases characterized by mitochondrial dysfunction and neuronal death. Mitophagy is a selective form of macroautophagy that clears injured mitochondria.
Kun Liu, Hangkuo Xin, Ting Zhu, Xiaohui Zheng, Wei Chen, Qingqing Xie, Danqi Feng, Shengyu Lin   +7 more
core   +1 more source