Results 51 to 60 of about 583 (139)
Communications BiologyProhibitin 2 (PHB2) is a highly conserved protein with essential roles in cell homeostasis and survival across different cell types. Previous studies have shown that the deletion of PHB2 results in an arrest in proliferation due to impaired mitochondrial
Johannes F. Vogt +18 more
doaj +1 more source
Scientific Reports, 2018 Prohibitin 2(PHB2) is a member of the SFPH trans-membrane family proteins. It is a highly conserved and functionally diverse protein that plays an important role in preserving the structure and function of the mitochondria.
Ying Shi +5 more
doaj +1 more source
Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome
Annals of Neurology, EarlyView.Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca +24 more
wiley +1 more source
Progressive astrogliosis and loss of hippocampal neurons in Phb2NKO mice.
, 2012 (A) Representative photographs of brains isolated from 14- or 20-week-old Phb2NKO and Phb2fl/fl control mice (upper panel). Brain weights of Phb2NKO and Phb2fl/fl control animals were monitored at the indicated time points (lower panel).
Anne Korwitz (122006) +7 more
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Bakuchiol: From structural mimicry to systems‐level skin biology
International Journal of Cosmetic Science, EarlyView.Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley +1 more source
Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse
Experimental Physiology, EarlyView.Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley +1 more source
, 2014 (A) Mouse ES cells (EBRTcH3) expressing with PHB2 shRNA. (B) ES cells (EBRTcH3) expressing a control shRNA. (C) Mouse D3 cells overexpressing PHB2. (D) D3 cells transfected with a control vector. Scale bar, 500 nm.
Ying Ying Wang (548374) +19 more
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The Journal of Physiology, EarlyView.Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray +16 more
wiley +1 more source
Screening of a Protein-Protein Interaction Focused Library Targeting BIG3-PHB2 Interaction [PDF]
Biophysical Journal, 2016 Endocrine resistance is one of the most challenging problems in estrogen receptor alpha (ERα)-positive breast cancer. The transcriptional activity of ERα is controlled by several coregulators, including prohibitin-2 (PHB2). Because of its ability to repress the transcriptional activity of activated ERα, PHB2 is a promising antiproliferative agent.
Chigira, Takeru +2 more
openaire +1 more source
Aging Cell, Volume 25, Issue 9, September 2026.Findings from this study suggest that aging is accompanied by altered skeletal muscle mitochondrial redox regulation and exercise responsiveness, with decreased mtDNA copy number, increased mtDNA mutation deletion frequency, and selective redox remodeling of key mitochondrial proteins representing potential contributors to these changes. ABSTRACT Redox
Bradley A. Ruple +11 more
wiley +1 more source