Results 41 to 50 of about 583 (139)
ASURA (PHB2) Is Required for Kinetochore Assembly and Subsequent Chromosome Congression
ACTA HISTOCHEMICA ET CYTOCHEMICA, 2011 ASURA (PHB2) knockdown has been known to cause premature loss of sister chromatid cohesion, and disrupt the localization of several outer plate proteins to the kinetochore. As a result, cells are arrested at mitotic phase and chromosomes fail to congress to the metaphase plate. In this study, we further clarified the mechanism underlying ASURA function
Lee, Mei Hann +5 more
openaire +3 more sources
, 2015 (A) The expression levels of the KPNA family of proteins in breast cancer cell lines and normal human mammary gland tissue were evaluated using semi-quantitative RT-PCR. ACTB is used as an internal control; (B, C) Immunoblotting analysis was performed to
Toyomasa Katagiri (25446) +9 more
core +1 more source
PHB2 is molecular clock component.
, 2012 (A) Representative graph (n = 3) of M34-luciferase reporter assays following transient cotransfections of M34-luc, renilla, GFP and indicated siRNAs without (left) or with (right) BMAL1 and CLOCK.
John M. Asara (180947) +5 more
core +1 more source
KPNA mediates the nuclear translocation of PHB2.
, 2015 (A) Immunoblotting analysis was performed to detect the subcellular localization of KPNA, ERα and PHB2. COS-7 cells co-transfected with HA-PHB2, each FLAG-KPNA and FLAG-ERα were treated with 10 nM E2 for 24 h and separated into cytoplasmic and nuclear ...
Toyomasa Katagiri (25446) +9 more
core +1 more source
Knockdown of PHB2 in ES cells causes induction of apoptosis.
, 2014 (A) Knockdown of endogenous PHB2 in mouse ES, NIH3T3, and C2C12 cells. Cells transiently transfected with a PHB2 shRNA-expressing plasmid were fixed 2 days after transfection and immunostained with a PHB2 antibody.
Ying Ying Wang (548374) +19 more
core +1 more source
Frontiers in PhysiologyAcute kidney injury (AKI), associated with a major health burden globally, is frequently caused by nephrotoxic agents, specifically cisplatin. Prohibitin (PHB) 2, a highly conserved mitochondrial protein localized at the inner mitochondrial membrane, is ...
Qi Zhang +4 more
doaj +1 more source
Cancer Medicine, 2018 Esophageal squamous cell carcinoma (ESCC) is the eighth cause of cancer‐related deaths worldwide. To screen potential biomarkers associated with early recurrence/metastasis (R/M) of ESCC patients after radical resection, ESCC patients were analyzed by a ...
Xu‐Wei Cai +9 more
doaj +1 more source
上海师范大学学报. 自然科学版, 2018 In order to detect the evolutionary level of prohibitin 2 (PHB2) gene, 10 species were selected to compare the PHB2 amino acid sequence with lamprey PHB2(Lm-PHB2), which was obtained by cloning from Chinese northeast lamprey (Lampetra morii) in present ...
SHI Ying +4 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave +8 more
wiley +1 more source
PHB2 localized in mitochondria is essential for the survival of pluripotent ES cells.
, 2014 (A) N-terminal sequence of the mitochondria-targeting signal mutated version of PHB2. (B) Establishment of shRNA-insensitive PHB2-GFP stable clones in mouse ES cells.
Ying Ying Wang (548374) +19 more
core +1 more source