Results 41 to 50 of about 2,921 (152)

The Role of Prohibitin-2 in Diseases

Frontiers in Bioscience-Landmark, 2023
Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis.
Fang Liu, You Zhang, Zhiyong Guo, An-Jing Ren   +3 more
doaj   +1 more source

Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.

PLoS ONE, 2012
Throughout the day, clock proteins synchronize changes in animal physiology (e.g., wakefulness and appetite) with external cues (e.g., daylight and food).
Lorna S Kategaya, Aisha Hilliard, Louying Zhang, John M Asara, Louis J Ptáček, Ying-Hui Fu   +5 more
doaj   +1 more source

ASURA (PHB2) Is Required for Kinetochore Assembly and Subsequent Chromosome Congression

ACTA HISTOCHEMICA ET CYTOCHEMICA, 2011
ASURA (PHB2) knockdown has been known to cause premature loss of sister chromatid cohesion, and disrupt the localization of several outer plate proteins to the kinetochore. As a result, cells are arrested at mitotic phase and chromosomes fail to congress to the metaphase plate. In this study, we further clarified the mechanism underlying ASURA function
Lee, Mei Hann, Lin, Linyen, Equilibrina, Ilma, Uchiyama, Susumu, Matsunaga, Sachihiro, Fukui, Kiichi   +5 more
openaire   +3 more sources

Targeting BIG3–PHB2 interaction to overcome tamoxifen resistance in breast cancer cells [PDF]

Nature Communications, 2013
The acquisition of endocrine resistance is a common obstacle in endocrine therapy of patients with oestrogen receptor-α (ERα)-positive breast tumours. We previously demonstrated that the BIG3-PHB2 complex has a crucial role in the modulation of oestrogen/ERα signalling in breast cancer cells.
Yoshimaru, Tetsuro, Komatsu, Masato, Matsuo, Taisuke, Chen, Yi-An, Murakami, Yoichi, Mizuguchi, Kenji, Mizohata, Eiichi, Inoue, Tsuyoshi, Akiyama, Miki, Yamaguchi, Rui, Imoto, Seiya, Miyano, Satoru, Miyoshi, Yasuo, Sasa, Mitsunori, Nakamura, Yusuke, Katagiri, Toyomasa   +15 more
openaire   +2 more sources

Tissue‐based quantitative proteomics to screen and identify the potential biomarkers for early recurrence/metastasis of esophageal squamous cell carcinoma

Cancer Medicine, 2018
Esophageal squamous cell carcinoma (ESCC) is the eighth cause of cancer‐related deaths worldwide. To screen potential biomarkers associated with early recurrence/metastasis (R/M) of ESCC patients after radical resection, ESCC patients were analyzed by a ...
Xu‐Wei Cai, Wei‐Wei Yu, Wen Yu, Qin Zhang, Wen Feng, Mi‐Na Liu, Meng‐Hong Sun, Jia‐Qing Xiang, Ya‐Wei Zhang, Xiao‐Long Fu   +9 more
doaj   +1 more source

Microarray analysis of gene expression profiling in Chang Liver cells associated with Lamprey-PHB2 transfection

上海师范大学学报. 自然科学版, 2018
In order to detect the evolutionary level of prohibitin 2 (PHB2) gene, 10 species were selected to compare the PHB2 amino acid sequence with lamprey PHB2(Lm-PHB2), which was obtained by cloning from Chinese northeast lamprey (Lampetra morii) in present ...
SHI Ying, LI Qing, GUO Sicheng, LI Qingwei, LI Tiesong   +4 more
doaj   +1 more source

PHB2 interacts with LC3 and SQSTM1 is required for bile acids-induced mitophagy in cholestatic liver [PDF]

Cell Death & Disease, 2018
AbstractMitophagy is a major pathway for clearance of injured mitochondria. However, whether mitophagy is involved in the cholestasis-induced damages of hepatic mitochondria remains unknown. We here aimed to investigate the molecular links between cholestasis and hepatic mitophagy.
Xiao, Yongtao, Zhou, Ying, Lu, Ying, Zhou, Kejun, Cai, Wei   +4 more
openaire   +2 more sources

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Prohibitin 2 is a key regulator of T cell proliferation, differentiation, and effector functions in vivo

Communications Biology
Prohibitin 2 (PHB2) is a highly conserved protein with essential roles in cell homeostasis and survival across different cell types. Previous studies have shown that the deletion of PHB2 results in an arrest in proliferation due to impaired mitochondrial
Johannes F. Vogt, Carsten Merkwirth, Petra Adams-Quack, Elena Zurkowski, Emmanouill Stylianakis, David C. Uhlfelder, Thomas Michna, Assel Nurbekova, Ute Distler, Liliana Rojas-Charry, Hajime Yurugi, Sonja Reißig, F. Thomas Wunderlich, Krishnaraj Rajalingam, Stefan Tenzer, Axel Methner, Thomas Langer, Ari Waisman, Nadine Hövelmeyer   +18 more
doaj   +1 more source